Slc26a3 solute carrier family 26 member 3 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Slc26a3provided by RGD
Official Full Name: solute carrier family 26 member 3provided by RGD
Primary source: RGD:620623
See related: EnsemblRapid:ENSRNOG00000006878 AllianceGenome:RGD:620623
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable chloride:bicarbonate antiporter activity; oxalate transmembrane transporter activity; and sulfate transmembrane transporter activity. Predicted to be involved in several processes, including cellular response to cAMP; inorganic anion transmembrane transport; and membrane hyperpolarization. Located in apical plasma membrane and brush border membrane. Human ortholog(s) of this gene implicated in congenital secretory chloride diarrhea 1 and diarrhea. Orthologous to human SLC26A3 (solute carrier family 26 member 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 9.9), Heart (RPKM 9.7) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 6q16

Exon count:: 21

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	6	NC_086024.1 (53751415..53792300)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	6	NC_051341.1 (48023892..48064829)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	6	NC_005105.4 (50725085..50766306)

Chromosome 6 - NC_086024.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity.
Title: mOrange2, a Genetically Encoded, pH Sensitive Fluorescent Protein, is an Alternative to BCECF-AM to Measure Intracellular pH to Determine NHE3 and DRA Activity.
Data indicate that solute carrier family 26, member 3 protein (Slc26a3) is expressed in male reproductive tract, and its expression pattern is related to the function.
Title: [Expression pattern of congenital chloride diarrhea pathogenic gene Slc26a3 in the reproductive tract of male rodents].
in addition to mediating pH-sensitive Cl(-) uptake, DRA may function as a modifier of other anion transport proteins
Title: Characteristics of rat downregulated in adenoma (rDRA) expressed in HEK 293 cells.

Submit: New GeneRIF Correction

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables bicarbonate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables bicarbonate transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables bicarbonate transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables chloride transmembrane transporter activity	ISO Inferred from Sequence Orthology more info
enables chloride transmembrane transporter activity	ISS Inferred from Sequence or Structural Similarity more info
enables chloride:bicarbonate antiporter activity	ISO Inferred from Sequence Orthology more info
enables oxalate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info
enables secondary active sulfate transmembrane transporter activity	IEA Inferred from Electronic Annotation more info
enables sulfate transmembrane transporter activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in bicarbonate transport	IEA Inferred from Electronic Annotation more info
involved_in cellular response to cAMP	ISO Inferred from Sequence Orthology more info
involved_in cellular response to cAMP	ISS Inferred from Sequence or Structural Similarity more info
involved_in chloride transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular pH elevation	ISO Inferred from Sequence Orthology more info
involved_in intracellular pH elevation	ISS Inferred from Sequence or Structural Similarity more info
involved_in membrane hyperpolarization	ISO Inferred from Sequence Orthology more info
involved_in membrane hyperpolarization	ISS Inferred from Sequence or Structural Similarity more info
involved_in oxalate transport	IEA Inferred from Electronic Annotation more info
involved_in sperm capacitation	ISO Inferred from Sequence Orthology more info
involved_in sperm capacitation	ISS Inferred from Sequence or Structural Similarity more info
involved_in sulfate transmembrane transport	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in brush border membrane	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	ISO Inferred from Sequence Orthology more info
located_in membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISO Inferred from Sequence Orthology more info
located_in sperm midpiece	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: chloride anion exchanger

Names: down-regulated in adenoma; solute carrier family 26 (anion exchanger), member 3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_053755.2 → NP_446207.1 chloride anion exchanger

See identical proteins and their annotated locations for NP_446207.1

Status: PROVISIONAL

Source sequence(s)

AF337809

UniProtKB/Swiss-Prot

Q924C9

UniProtKB/TrEMBL

A6HB46

Related

ENSRNOP00000009473.3, ENSRNOT00000009473.5

Conserved Domains (2) summary

cd07042
Location:519 → 705

STAS_SulP_like_sulfate_transporter; Sulphate Transporter and Anti-Sigma factor antagonist domain of SulP-like sulfate transporters, plays a role in the function and regulation of the transport activity, proposed general NTP binding function

pfam00916
Location:73 → 468

Sulfate_transp; Sulfate permease family