Taok1 TAO kinase 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Taok1provided by RGD
Official Full Name: TAO kinase 1provided by RGD
Primary source: RGD:708455
See related: EnsemblRapid:ENSRNOG00000015692 AllianceGenome:RGD:708455
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables several functions, including myosin V binding activity; protein kinase binding activity; and protein serine/threonine kinase activator activity. Involved in protein autophosphorylation; regulation of actin cytoskeleton organization; and regulation of microtubule cytoskeleton organization. Predicted to be located in microtubule cytoskeleton and perinuclear region of cytoplasm. Predicted to be active in cytoplasm. Orthologous to human TAOK1 (TAO kinase 1). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Lung (RPKM 423.5), Adrenal (RPKM 405.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 10q24

Exon count:: 26

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (62871198..62989049, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (62373072..62465295, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (62542870..62630341)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

TAOK1-mediated regulation of the YAP/TEAD pathway as a potential therapeutic target in heart failure.
Title: TAOK1-mediated regulation of the YAP/TEAD pathway as a potential therapeutic target in heart failure.
Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors.
Title: Thousand and one kinase 1 protects MCAO-induced cerebral ischemic stroke in rats by decreasing apoptosis and pro-inflammatory factors.
Inhibition of miR-183 in cochlear organotypic culture leads to upregulation of Taok1. Exposure to noise caused a significant upregulation of Taok1.
Title: The miR-183/Taok1 target pair is implicated in cochlear responses to acoustic trauma.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables 3-phosphoinositide-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables AMP-activated protein kinase activity	IEA Inferred from Electronic Annotation more info
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA-dependent protein kinase activity	IEA Inferred from Electronic Annotation more info
enables Rho-dependent protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables alpha-tubulin binding	ISO Inferred from Sequence Orthology more info
enables beta-tubulin binding	ISO Inferred from Sequence Orthology more info
enables eukaryotic translation initiation factor 2alpha kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS1 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AS121 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AT120 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2AXS139 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS14 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H2BS36 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S10 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S28 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3S57 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T11 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T3 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T45 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H3T6 kinase activity	IEA Inferred from Electronic Annotation more info
enables histone H4S1 kinase activity	IEA Inferred from Electronic Annotation more info
enables kinase activity	ISO Inferred from Sequence Orthology more info
enables myosin V binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase activator activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables protein kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein serine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine kinase activity	IDA Inferred from Direct Assay more info	PubMed
enables protein serine/threonine kinase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine kinase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables ribosomal protein S6 kinase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in DNA damage response	ISO Inferred from Sequence Orthology more info
involved_in DNA damage response	ISS Inferred from Sequence or Structural Similarity more info
involved_in DNA repair	IEA Inferred from Electronic Annotation more info
involved_in central nervous system neuron development	IEA Inferred from Electronic Annotation more info
involved_in central nervous system neuron development	ISO Inferred from Sequence Orthology more info
involved_in central nervous system neuron development	ISS Inferred from Sequence or Structural Similarity more info
involved_in chromatin remodeling	IEA Inferred from Electronic Annotation more info
involved_in execution phase of apoptosis	ISO Inferred from Sequence Orthology more info
involved_in execution phase of apoptosis	ISS Inferred from Sequence or Structural Similarity more info
involved_in microtubule cytoskeleton organization	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISO Inferred from Sequence Orthology more info
involved_in mitotic G2 DNA damage checkpoint signaling	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of microtubule depolymerization	ISO Inferred from Sequence Orthology more info
involved_in neuron cellular homeostasis	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of JNK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of JNK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of protein acetylation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of stress-activated MAPK cascade	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of stress-activated MAPK cascade	ISS Inferred from Sequence or Structural Similarity more info
involved_in protein autophosphorylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein phosphorylation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of actin cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of cytoskeleton organization	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cytoskeleton organization	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of microtubule cytoskeleton organization	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in microtubule cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in perinuclear region of cytoplasm	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: serine/threonine-protein kinase TAO1

Names: thousand and one amino acid protein 1

NP_775449.2

EC 2.7.11.1

XP_038941256.1

EC 2.7.11.1

XP_038941257.1

EC 2.7.11.1

XP_038941258.1

EC 2.7.11.1

XP_038941260.1

EC 2.7.11.1

XP_063124576.1

EC 2.7.11.1

XP_063124577.1

EC 2.7.11.1

XP_063124578.1

EC 2.7.11.1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_173327.3 → NP_775449.2 serine/threonine-protein kinase TAO1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

O88664

UniProtKB/TrEMBL

A6HGY8

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

62871198..62989049 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063268508.1 → XP_063124578.1 serine/threonine-protein kinase TAO1 isoform X1

UniProtKB/TrEMBL

A6HGY8
XM_063268507.1 → XP_063124577.1 serine/threonine-protein kinase TAO1 isoform X1

UniProtKB/TrEMBL

A6HGY8
XM_039085332.2 → XP_038941260.1 serine/threonine-protein kinase TAO1 isoform X1

UniProtKB/Swiss-Prot

O88664

UniProtKB/TrEMBL

A6HGY8

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
XM_039085330.2 → XP_038941258.1 serine/threonine-protein kinase TAO1 isoform X1

UniProtKB/Swiss-Prot

O88664

UniProtKB/TrEMBL

A6HGY8

Related

ENSRNOP00000021368.8, ENSRNOT00000021368.8

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
XM_039085328.2 → XP_038941256.1 serine/threonine-protein kinase TAO1 isoform X1

UniProtKB/Swiss-Prot

O88664

UniProtKB/TrEMBL

A6HGY8

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1
XM_063268506.1 → XP_063124576.1 serine/threonine-protein kinase TAO1 isoform X1

UniProtKB/TrEMBL

A6HGY8
XM_039085329.2 → XP_038941257.1 serine/threonine-protein kinase TAO1 isoform X1

UniProtKB/Swiss-Prot

O88664

UniProtKB/TrEMBL

A6HGY8

Conserved Domains (2) summary

COG0419
Location:442 → 877

SbcC; DNA repair exonuclease SbcCD ATPase subunit [Replication, recombination and repair]

cd06635
Location:2 → 318

STKc_TAO1; Catalytic domain of the Serine/Threonine Kinase, Thousand-and-One Amino acids 1