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    EIF3CL eukaryotic translation initiation factor 3 subunit C like [ Homo sapiens (human) ]

    Gene ID: 728689, updated on 10-Dec-2024

    Summary

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    Official Symbol
    EIF3CLprovided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 3 subunit C likeprovided by HGNC
    Primary source
    HGNC:HGNC:26347
    See related
    Ensembl:ENSG00000205609 AllianceGenome:HGNC:26347
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Summary
    The protein encoded by this gene is a core subunit of the eukaryotic translation initiation factor 3 (eIF3) complex. The encoded protein is nearly identical to another protein, eIF3c, from a related gene. The eIF3 complex binds the 40S ribosome and mRNAs to enable translation initiation. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 103.1), thyroid (RPKM 97.8) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See EIF3CL in Genome Data Viewer
    Location:
    16p12.1
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (28379581..28426418, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (28659992..28707115, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (28390902..28415206, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene SH3 domain binding kinase 1 Neighboring gene uncharacterized LOC124903670 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:28303338-28303509 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7307 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28341775-28342274 Neighboring gene MPRA-validated peak2550 silencer Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:28347523-28348022 Neighboring gene nuclear pore complex interacting protein family member B6 Neighboring gene microRNA 6862-1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28414989-28415489 Neighboring gene cell division cycle 37 pseudogene 2 Neighboring gene small nucleolar RNA U13 Neighboring gene H3K27ac hESC enhancer GRCh37_chr16:28459200-28460080 Neighboring gene nuclear pore complex interacting protein family member B7 Neighboring gene CLN3 lysosomal/endosomal transmembrane protein, battenin

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

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    Related articles in PubMed

    1. Structural roles for human translation factor eIF3 in initiation of protein synthesis. Siridechadilok B, et al. Science, 2005 Dec 2. PMID 16322461
    2. Binding of eukaryotic initiation factor 3 to ribosomal 40S subunits and its role in ribosomal dissociation and anti-association. Kolupaeva VG, et al. RNA, 2005 Apr. PMID 15703437, Free PMC Article
    3. Automated phosphoproteome analysis for cultured cancer cells by two-dimensional nanoLC-MS using a calcined titania/C18 biphasic column. Imami K, et al. Anal Sci, 2008 Jan. PMID 18187866
    4. Interaction between the Ret finger protein and the Int-6 gene product and co-localisation into nuclear bodies. Morris-Desbois C, et al. J Cell Sci, 1999 Oct. PMID 10504338
    5. Global proteomic profiling of phosphopeptides using electron transfer dissociation tandem mass spectrometry. Molina H, et al. Proc Natl Acad Sci U S A, 2007 Feb 13. PMID 17287340, Free PMC Article

    See all (74) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    EBI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    contributes_to translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables translation initiation factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in formation of cytoplasmic translation initiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in translational initiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    part_of eukaryotic 43S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic 48S preinitiation complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of eukaryotic translation initiation factor 3 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    eukaryotic translation initiation factor 3 subunit C-like protein
    Names
    eIF3 p110
    eukaryotic translation initiation factor 3 subunit 8
    eukaryotic translation initiation factor 3, subunit 8, 110kDa-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001099661.2 → NP_001093131.1  eukaryotic translation initiation factor 3 subunit C-like protein

      See identical proteins and their annotated locations for NP_001093131.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC138894, CA420261, DA645577, DC410988
      Consensus CDS
      CCDS42136.1
      UniProtKB/Swiss-Prot
      B5ME19
      UniProtKB/TrEMBL
      A1KYQ7
      Related
      ENSP00000381917.3, ENST00000398944.7
      Conserved Domains (2) summary
      smart00753
      Location:779 → 867
      PAM; PCI/PINT associated module
      pfam05470
      Location:29 → 706
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

    2. NM_001317856.1 → NP_001304785.1  eukaryotic translation initiation factor 3 subunit C-like protein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. All three variants encode the same protein.
      Source sequence(s)
      AC138894, BQ686089, CA420261, DC410988
      Consensus CDS
      CCDS42136.1
      UniProtKB/Swiss-Prot
      B5ME19
      UniProtKB/TrEMBL
      A1KYQ7
      Conserved Domains (2) summary
      smart00753
      Location:779 → 867
      PAM; PCI/PINT associated module
      pfam05470
      Location:29 → 706
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

    3. NM_001317857.2 → NP_001304786.1  eukaryotic translation initiation factor 3 subunit C-like protein

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript. All three variants encode the same protein.
      Source sequence(s)
      AC138894, DC410988
      Consensus CDS
      CCDS42136.1
      UniProtKB/Swiss-Prot
      B5ME19
      UniProtKB/TrEMBL
      A1KYQ7
      Related
      ENSP00000370258.5, ENST00000380876.5
      Conserved Domains (2) summary
      smart00753
      Location:779 → 867
      PAM; PCI/PINT associated module
      pfam05470
      Location:29 → 706
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      28379581..28426418 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434558.1 → XP_047290514.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X1

      UniProtKB/Swiss-Prot
      B5ME19
      UniProtKB/TrEMBL
      A1KYQ7

    2. XM_017023621.2 → XP_016879110.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X3

      UniProtKB/TrEMBL
      B3KNZ4
      Conserved Domains (2) summary
      smart00088
      Location:462 → 550
      PINT; motif in proteasome subunits, Int-6, Nip-1 and TRIP-15
      pfam05470
      Location:2 → 389
      eIF-3c_N; Eukaryotic translation initiation factor 3 subunit 8 N-terminus

    3. XM_017023620.3 → XP_016879109.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X2

      UniProtKB/TrEMBL
      A1KYQ7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      28659992..28707115 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313819.1 → XP_054169794.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X1

      UniProtKB/Swiss-Prot
      A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
      UniProtKB/TrEMBL
      A1KYQ7

    2. XM_054313817.1 → XP_054169792.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X1

      UniProtKB/Swiss-Prot
      A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
      UniProtKB/TrEMBL
      A1KYQ7

    3. XM_054313818.1 → XP_054169793.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X1

      UniProtKB/Swiss-Prot
      A8K7Z0, B2RXG3, B4E1D5, H3BRV0, O00215, Q99613, Q9BW98
      UniProtKB/TrEMBL
      A1KYQ7

    4. XM_054313820.1 → XP_054169795.1  eukaryotic translation initiation factor 3 subunit C-like protein isoform X3

      UniProtKB/TrEMBL
      B3KNZ4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B5ME19.1 GenPept UniProtKB/Swiss-Prot:B5ME19

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