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    THOC3 THO complex subunit 3 [ Homo sapiens (human) ]

    Gene ID: 84321, updated on 10-Dec-2024

    Summary

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    Official Symbol
    THOC3provided by HGNC
    Official Full Name
    THO complex subunit 3provided by HGNC
    Primary source
    HGNC:HGNC:19072
    See related
    Ensembl:ENSG00000051596 MIM:606929; AllianceGenome:HGNC:19072
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    THO3; hTREX45
    Summary
    This gene encodes a component of the nuclear THO transcription elongation complex, which is part of the larger transcription export (TREX) complex that couples messenger RNA processing and export. In humans, the transcription export complex is recruited to the 5'-end of messenger RNAs in a splicing- and cap-dependent manner. Studies of a related complex in mouse suggest that the metazoan transcription export complex is involved in cell differentiation and development. A pseudogene of this gene has been defined on chromosome 5. [provided by RefSeq, May 2013]
    Expression
    Ubiquitous expression in esophagus (RPKM 29.0), testis (RPKM 21.2) and 24 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See THOC3 in Genome Data Viewer
    Location:
    5q35.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (175959531..175968315, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (176503198..176512029, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (175386534..175395318, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124901140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175247615-175248115 Neighboring gene uncharacterized LOC105377744 Neighboring gene complexin 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16646 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175273819-175274388 Neighboring gene NANOG hESC enhancer GRCh37_chr5:175288336-175288837 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175298998-175299721 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175299722-175300444 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175305917-175306647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:175306648-175307378 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:175335086-175335928 Neighboring gene OCT4-H3K27ac hESC enhancer GRCh37_chr5:175394535-175395057 Neighboring gene THOC3 antisense RNA 1 Neighboring gene uncharacterized LOC124900194 Neighboring gene olfactory receptor family 1 subfamily X member 1 pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. THOC3 interacts with YBX1 to promote lung squamous cell carcinoma progression through PFKFB4 mRNA modification. Yu T, et al. Cell Death Dis, 2023 Jul 27. PMID 37500615, Free PMC Article
    2. Aly and THO are required for assembly of the human TREX complex and association of TREX components with the spliced mRNA. Chi B, et al. Nucleic Acids Res, 2013 Jan. PMID 23222130, Free PMC Article
    3. TREX is a conserved complex coupling transcription with messenger RNA export. Strässer K, et al. Nature, 2002 May 16. PMID 11979277
    4. Linking transcriptional elongation and messenger RNA export to metastatic breast cancers. Guo S, et al. Cancer Res, 2005 Apr 15. PMID 15833825
    5. mRNA export and the TREX complex. Katahira J. Biochim Biophys Acta, 2012 Jun. PMID 22178508

    See all (75) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Phenotypes

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    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC5469

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in RNA splicing IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA export from nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in mRNA export from nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in mRNA processing IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of THO complex part of transcription export complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of THO complex part of transcription export complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    colocalizes_with chromosome, telomeric region IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    part_of transcription export complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    THO complex subunit 3
    Names
    TEX1 homolog
    THO complex 3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001376902.1 → NP_001363831.1  THO complex subunit 3 isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC138965
      Consensus CDS
      CCDS93829.1
      Related
      ENSP00000422243.1, ENST00000513482.1
      Conserved Domains (2) summary
      cd00200
      Location:49 → 290
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:59 → 97
      7WD40; WD40 repeat [structural motif]

    2. NM_032361.4 → NP_115737.1  THO complex subunit 3 isoform 1

      See identical proteins and their annotated locations for NP_115737.1

      Status: REVIEWED

      Source sequence(s)
      AC138965
      Consensus CDS
      CCDS4397.1
      UniProtKB/Swiss-Prot
      Q6NZ53, Q96J01
      Related
      ENSP00000265097.5, ENST00000265097.9
      Conserved Domains (2) summary
      cd00200
      Location:49 → 290
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      sd00039
      Location:59 → 97
      7WD40; WD40 repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      175959531..175968315 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      176503198..176512029 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q96J01.1 GenPept UniProtKB/Swiss-Prot:Q96J01

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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