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    Pkp4 plakophilin 4 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 295625, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Pkp4provided by RGD
    Official Full Name
    plakophilin 4provided by RGD
    Primary source
    RGD:1307840
    See related
    EnsemblRapid:ENSRNOG00000005504 AllianceGenome:RGD:1307840
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable cadherin binding activity. Predicted to be involved in several processes, including cell-cell junction assembly; positive regulation of GTPase activity; and positive regulation of cytokinesis. Predicted to be located in several cellular components, including cell-cell contact zone; postsynaptic density; and spindle. Predicted to be active in several cellular components, including adherens junction; nucleus; and plasma membrane. Orthologous to human PKP4 (plakophilin 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Brain (RPKM 372.4), Kidney (RPKM 338.6) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Pkp4 in Genome Data Viewer
    Location:
    3q21
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 3 NC_086021.1 (64040995..64244586)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 3 NC_051338.1 (43632364..43835834)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 3 NC_005102.4 (45211097..45414524)

    Chromosome 3 - NC_086021.1Genomic Context describing neighboring genes Neighboring gene uridine phosphorylase 2 Neighboring gene coiled-coil domain containing 148 Neighboring gene basic proline-rich protein-like Neighboring gene dynein light chain roadblock-type 1 pseudogene Neighboring gene ribosomal protein S14, pseudogene 3

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Cloning and characterization of a new armadillo family member, p0071, associated with the junctional plaque: evidence for a subfamily of closely related proteins. Hatzfeld M, et al. J Cell Sci, 1996 Nov. PMID 8937994
    2. Folliculin interacts with p0071 (plakophilin-4) and deficiency is associated with disordered RhoA signalling, epithelial polarization and cytokinesis. Nahorski MS, et al. Hum Mol Genet, 2012 Dec 15. PMID 22965878, Free PMC Article
    3. The armadillo protein p0071 regulates Rho signalling during cytokinesis. Wolf A, et al. Nat Cell Biol, 2006 Dec. PMID 17115030
    4. Qualitative and quantitative analyses of protein phosphorylation in naive and stimulated mouse synaptosomal preparations. Munton RP, et al. Mol Cell Proteomics, 2007 Feb. PMID 17114649
    5. Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium. Gaudet P, et al. Brief Bioinform, 2011 Sep. PMID 21873635, Free PMC Article

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables cadherin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cell-cell junction assembly ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of GTPase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cytokinesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in adherens junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell contact zone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cell-cell junction ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasmic side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in desmosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in perinuclear region of cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in plasma membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic density ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle midzone ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in spindle pole ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    plakophilin-4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001427440.1 → NP_001414369.1  plakophilin-4

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000003
      UniProtKB/TrEMBL
      A0A8I6A880

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086021.1 Reference GRCr8

      Range
      64040995..64244586
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039106305.2 → XP_038962233.1  plakophilin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236 → 393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:634 → 675
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:879 → 1000
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:561 → 586
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:590 → 629
      Arm; Armadillo/beta-catenin-like repeat

    2. XM_039106316.2 → XP_038962244.1  plakophilin-4 isoform X13

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236 → 393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:896 → 931
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:879 → 1000
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:561 → 586
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:590 → 629
      Arm; Armadillo/beta-catenin-like repeat

    3. XM_039106310.2 → XP_038962238.1  plakophilin-4 isoform X4

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236 → 393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:618 → 659
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:863 → 984
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:545 → 570
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:574 → 613
      Arm; Armadillo/beta-catenin-like repeat

    4. XM_063283257.1 → XP_063139327.1  plakophilin-4 isoform X16

    5. XM_039106307.2 → XP_038962235.1  plakophilin-4 isoform X2

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236 → 393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:633 → 674
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:878 → 999
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:560 → 585
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:589 → 628
      Arm; Armadillo/beta-catenin-like repeat

    6. XM_063283255.1 → XP_063139325.1  plakophilin-4 isoform X14

    7. XM_039106311.2 → XP_038962239.1  plakophilin-4 isoform X6

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236 → 393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:617 → 658
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:862 → 983
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:544 → 569
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:573 → 612
      Arm; Armadillo/beta-catenin-like repeat

    8. XM_039106308.2 → XP_038962236.1  plakophilin-4 isoform X3

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:234 → 391
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:632 → 673
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:877 → 998
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:559 → 584
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:588 → 627
      Arm; Armadillo/beta-catenin-like repeat

    9. XM_063283252.1 → XP_063139322.1  plakophilin-4 isoform X8

    10. XM_039106309.2 → XP_038962237.1  plakophilin-4 isoform X5

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      smart00185
      Location:618 → 659
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:863 → 984
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:545 → 570
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:574 → 613
      Arm; Armadillo/beta-catenin-like repeat
      pfam03154
      Location:72 → 382
      Atrophin-1; Atrophin-1 family

    11. XM_063283256.1 → XP_063139326.1  plakophilin-4 isoform X15

      UniProtKB/TrEMBL
      A0A8I6A222

    12. XM_063283258.1 → XP_063139328.1  plakophilin-4 isoform X17

    13. XM_063283251.1 → XP_063139321.1  plakophilin-4 isoform X7

    14. XM_017592152.3 → XP_017447641.1  plakophilin-4 isoform X10

      UniProtKB/TrEMBL
      A0A8I5ZTQ8

    15. XM_039106317.2 → XP_038962245.1  plakophilin-4 isoform X18

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      smart00185
      Location:863 → 898
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:846 → 967
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:528 → 553
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:557 → 596
      Arm; Armadillo/beta-catenin-like repeat
      pfam03154
      Location:72 → 382
      Atrophin-1; Atrophin-1 family

    16. XM_063283253.1 → XP_063139323.1  plakophilin-4 isoform X9

    17. XM_039106314.2 → XP_038962242.1  plakophilin-4 isoform X11

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Related
      ENSRNOP00000056013.5, ENSRNOT00000059246.7
      Conserved Domains (5) summary
      smart00185
      Location:862 → 897
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:845 → 966
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:527 → 552
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:556 → 595
      Arm; Armadillo/beta-catenin-like repeat
      pfam03154
      Location:72 → 380
      Atrophin-1; Atrophin-1 family

    18. XM_063283259.1 → XP_063139329.1  plakophilin-4 isoform X19

    19. XM_039106315.2 → XP_038962243.1  plakophilin-4 isoform X12

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      smart00185
      Location:861 → 896
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:844 → 965
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:526 → 551
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:555 → 594
      Arm; Armadillo/beta-catenin-like repeat
      pfam03154
      Location:72 → 380
      Atrophin-1; Atrophin-1 family

    20. XM_039106318.2 → XP_038962246.1  plakophilin-4 isoform X20

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      smart00185
      Location:599 → 640
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:844 → 965
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:526 → 551
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:555 → 594
      Arm; Armadillo/beta-catenin-like repeat
      pfam03154
      Location:72 → 380
      Atrophin-1; Atrophin-1 family

    21. XM_039106321.2 → XP_038962249.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:72 → 229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:470 → 511
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:715 → 836
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:397 → 422
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:426 → 465
      Arm; Armadillo/beta-catenin-like repeat

    22. XM_006234216.5 → XP_006234278.1  plakophilin-4 isoform X1

      See identical proteins and their annotated locations for XP_006234278.1

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236 → 393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:634 → 675
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:879 → 1000
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:561 → 586
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:590 → 629
      Arm; Armadillo/beta-catenin-like repeat

    23. XM_039106306.2 → XP_038962234.1  plakophilin-4 isoform X1

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:236 → 393
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:634 → 675
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:879 → 1000
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:561 → 586
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:590 → 629
      Arm; Armadillo/beta-catenin-like repeat

    24. XM_063283250.1 → XP_063139320.1  plakophilin-4 isoform X5

    25. XM_063283254.1 → XP_063139324.1  plakophilin-4 isoform X12

    26. XM_063283261.1 → XP_063139331.1  plakophilin-4 isoform X21

    27. XM_063283263.1 → XP_063139333.1  plakophilin-4 isoform X21

    28. XM_063283265.1 → XP_063139335.1  plakophilin-4 isoform X21

    29. XM_063283262.1 → XP_063139332.1  plakophilin-4 isoform X21

    30. XM_063283260.1 → XP_063139330.1  plakophilin-4 isoform X21

    31. XM_063283267.1 → XP_063139337.1  plakophilin-4 isoform X22

    32. XM_039106322.2 → XP_038962250.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:72 → 229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:470 → 511
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:715 → 836
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:397 → 422
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:426 → 465
      Arm; Armadillo/beta-catenin-like repeat

    33. XM_063283266.1 → XP_063139336.1  plakophilin-4 isoform X21

    34. XM_063283264.1 → XP_063139334.1  plakophilin-4 isoform X21

    35. XM_039106324.2 → XP_038962252.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:72 → 229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:470 → 511
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:715 → 836
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:397 → 422
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:426 → 465
      Arm; Armadillo/beta-catenin-like repeat

    36. XM_039106325.2 → XP_038962253.1  plakophilin-4 isoform X21

      UniProtKB/TrEMBL
      A0A8I5ZTQ8
      Conserved Domains (5) summary
      PLN03209
      Location:72 → 229
      PLN03209; translocon at the inner envelope of chloroplast subunit 62; Provisional
      smart00185
      Location:470 → 511
      ARM; Armadillo/beta-catenin-like repeats
      PLN03200
      Location:715 → 836
      PLN03200; cellulose synthase-interactive protein; Provisional
      sd00043
      Location:397 → 422
      ARM; armadillo repeat [structural motif]
      pfam00514
      Location:426 → 465
      Arm; Armadillo/beta-catenin-like repeat

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_001106482.1: Suppressed sequence

      Description
      NM_001106482.1: This RefSeq was suppressed temporarily based on the calculation that the encoded protein was shorter than proteins from the putative ortholog from chicken: PKP4 (GeneID:424328).
    Nucleotide Protein Strain
    Heading Accession and Version

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