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    Fbh1 F-box DNA helicase 1 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 291293, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Fbh1provided by RGD
    Official Full Name
    F-box DNA helicase 1provided by RGD
    Primary source
    RGD:1306298
    See related
    EnsemblRapid:ENSRNOG00000018549 AllianceGenome:RGD:1306298
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    Fbxo18
    Summary
    Predicted to enable ATP-dependent activity, acting on DNA and DNA binding activity. Predicted to be involved in DNA metabolic process; negative regulation of double-strand break repair via homologous recombination; and protein ubiquitination. Predicted to act upstream of or within several processes, including DNA catabolic process; positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage; and response to intra-S DNA damage checkpoint signaling. Predicted to be located in chromatin. Predicted to be part of SCF ubiquitin ligase complex. Predicted to be active in nucleus. Orthologous to human FBH1 (F-box DNA helicase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Kidney (RPKM 280.1), Thymus (RPKM 256.2) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Fbh1 in Genome Data Viewer
    Location:
    17q12.2
    Exon count:
    24
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 17 NC_086035.1 (71659351..71697431)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 17 NC_051352.1 (66749506..66787590)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 17 NC_005116.4 (70399093..70437151)

    Chromosome 17 - NC_086035.1Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC120097862 Neighboring gene ankyrin repeat domain 16 Neighboring gene interleukin 15 receptor subunit alpha Neighboring gene actin related protein 2/3 complex, subunit 5-like, pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Human Fbh1 helicase contributes to genome maintenance via pro- and anti-recombinase activities. Fugger K, et al. J Cell Biol, 2009 Sep 7. PMID 19736316, Free PMC Article
    2. Single-molecule sorting reveals how ubiquitylation affects substrate recognition and activities of FBH1 helicase. Masuda-Ozawa T, et al. Nucleic Acids Res, 2013 Apr 1. PMID 23393192, Free PMC Article
    3. FBH1 helicase disrupts RAD51 filaments in vitro and modulates homologous recombination in mammalian cells. Simandlova J, et al. J Biol Chem, 2013 Nov 22. PMID 24108124, Free PMC Article
    4. The novel human DNA helicase hFBH1 is an F-box protein. Kim J, et al. J Biol Chem, 2002 Jul 5. PMID 11956208
    5. FBH1 influences DNA replication fork stability and homologous recombination through ubiquitylation of RAD51. Chu WK, et al. Nat Commun, 2015 Jan 14. PMID 25585578

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables 3'-5' DNA helicase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables 3'-5' DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA helicase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA translocase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables double-stranded DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables forked DNA-dependent helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables four-way junction helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables isomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded 3'-5' DNA helicase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables single-stranded DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within DNA catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA damage response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in DNA duplex unwinding IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in DNA repair ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in double-strand break repair via homologous recombination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in negative regulation of double-strand break repair via homologous recombination ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within positive regulation of protein phosphorylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in replication fork processing IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in replication fork processing ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within response to intra-S DNA damage checkpoint signaling ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    part_of SCF ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    F-box DNA helicase 1
    Names
    F-box only protein 18
    F-box protein, helicase, 18
    NP_001099589.1
    XP_038951462.1
    XP_038951464.1
    XP_038951465.1
    XP_063132308.1
    XP_063132309.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106119.1 → NP_001099589.1  F-box DNA helicase 1

      See identical proteins and their annotated locations for NP_001099589.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473990
      UniProtKB/TrEMBL
      A6JLR6, F1M298
      Related
      ENSRNOP00000105146.1, ENSRNOT00000170477.1
      Conserved Domains (4) summary
      COG0210
      Location:439 → 931
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      pfam12937
      Location:210 → 259
      F-box-like; F-box-like
      pfam13538
      Location:870 → 931
      UvrD_C_2; UvrD-like helicase C-terminal domain
      cl21455
      Location:440 → 684
      P-loop_NTPase; P-loop containing Nucleoside Triphosphate Hydrolases

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086035.1 Reference GRCr8

      Range
      71659351..71697431
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063276239.1 → XP_063132309.1  F-box DNA helicase 1 isoform X3

    2. XM_039095537.2 → XP_038951465.1  F-box DNA helicase 1 isoform X2

      Conserved Domains (2) summary
      COG0210
      Location:204 → 696
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      cd18786
      Location:600 → 697
      SF1_C; C-terminal helicase domain of superfamily 1 DEAD/H-box helicases

    3. XM_039095536.2 → XP_038951464.1  F-box DNA helicase 1 isoform X2

      Conserved Domains (2) summary
      COG0210
      Location:204 → 696
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      cd18786
      Location:600 → 697
      SF1_C; C-terminal helicase domain of superfamily 1 DEAD/H-box helicases

    4. XM_039095534.2 → XP_038951462.1  F-box DNA helicase 1 isoform X2

      Conserved Domains (2) summary
      COG0210
      Location:204 → 696
      UvrD; Superfamily I DNA or RNA helicase [Replication, recombination and repair]
      cd18786
      Location:600 → 697
      SF1_C; C-terminal helicase domain of superfamily 1 DEAD/H-box helicases

    5. XM_063276238.1 → XP_063132308.1  F-box DNA helicase 1 isoform X1

      Related
      ENSRNOP00000103934.1, ENSRNOT00000127043.1
    Nucleotide Protein Strain
    Heading Accession and Version

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