Hspg2 heparan sulfate proteoglycan 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Symbol: Hspg2provided by RGD
Full Name: heparan sulfate proteoglycan 2provided by RGD
Primary source: RGD:621770
See related: EnsemblRapid:ENSRNOG00000021437 AllianceGenome:RGD:621770
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Per; AABR07073181.1
Summary: Enables collagen V binding activity. Involved in several processes, including animal organ regeneration; embryo implantation; and positive regulation of endothelial cell proliferation. Located in collagen-containing extracellular matrix. Biomarker of hypertension. Human ortholog(s) of this gene implicated in Schwartz-Jampel syndrome 1; Silverman-Handmaker type dyssegmental dysplasia; and osteochondrodysplasia. Orthologous to human HSPG2 (heparan sulfate proteoglycan 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 325.9), Adrenal (RPKM 312.2) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 5q36

Exon count:: 103

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	5	NC_086023.1 (154960818..155061971)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	5	NC_051340.1 (149677437..149778594)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	5	NC_005104.4 (155812096..155913751)

Chromosome 5 - NC_086023.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Maternal protein restriction reduces the expression of perlecan and leads to aberrant cell proliferation and apoptosis during mid-metanephrogenesis in offspring.
Title: Maternal protein restriction reduces perlecan at mid-metanephrogenesis in rats.
perlecan is an attractive candidate to promote regenerative mechanisms and to suppress reactions that hamper regenerative processes in cases of CNS injury.
Title: Diverse functions of perlecan in central nervous system cells in vitro.
Down-regulation of perlecan expression contributes to hypoxia-induced inhibition of rat cardiac microvascular endothelial cell proliferation by suppressing FAK-mediated and ERK1/2-dependent growth signals.
Title: Down-regulation of perlecan expression contributes to the inhibition of rat cardiac microvascular endothelial cell proliferation induced by hypoxia.
The neuroprotective effects of perlecan domain V on astrocytes under physiological and pathological situations are studied in both in vitro and in vivo models.
Title: Perlecan domain V modulates astrogliosis in vitro and after focal cerebral ischemia through multiple receptors and increased nerve growth factor release.
This study shows for the first time that mast cells secrete and process the extracellular proteoglycan perlecan into fragments containing the endorepellin C-terminal region that regulate angiogenesis and matrix turnover
Title: Mast cells produce novel shorter forms of perlecan that contain functional endorepellin: a role in angiogenesis and wound healing.
elevated levels of perlecan domain V have a role in brain repair post stroke via VEGF and brain endothelial cell alpha5beta1 integrin
Title: Perlecan domain V is neuroprotective and proangiogenic following ischemic stroke in rodents.
Perlecan may inhibit the proliferative response of SMCs after vascular injury.
Title: Changes in perlecan expression during vascular injury: role in the inhibition of smooth muscle cell proliferation in the late lesion.
Perlecan synthesis increases as oligodendrocytes undergo terminal differentiation; astrocytes express glypican-1 and perlecan but not syndecan-3.
Title: Syndecan-3 and perlecan are differentially expressed by progenitors and mature oligodendrocytes and accumulate in the extracellular matrix.
Data show that upon experimental and human renal ischemia/reperfusion, microvascular basement membrane (BM) heparan sulfate proteoglycans (collagen 18alpha1, agrin and perlecan) are modified to bind L-selectin and monocyte chemoattractant protein-1.
Title: Subendothelial heparan sulfate proteoglycans become major L-selectin and monocyte chemoattractant protein-1 ligands upon renal ischemia/reperfusion.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Hspg2 (e-PCR), detects polymorphism
- UniSTS:472865

d5rat66 (e-PCR)
- UniSTS:122157

BM385095 (e-PCR)
- UniSTS:260960

BE099553 (e-PCR)
- UniSTS:245693

AU047918 (e-PCR)
- UniSTS:110048

RH129941 (e-PCR)
- UniSTS:213229

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables axon guidance receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables calcium ion binding	IEA Inferred from Electronic Annotation more info
enables collagen V binding	IPI Inferred from Physical Interaction more info	PubMed
enables protease binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in animal organ regeneration	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within brain development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cardiac muscle tissue development	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cartilage development involved in endochondral bone morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within chondrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in embryo implantation	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within endochondral ossification	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within extracellular matrix organization	ISO Inferred from Sequence Orthology more info
involved_in homophilic cell adhesion via plasma membrane adhesion molecules	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of amyloid fibril formation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell adhesion	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of cell population proliferation	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of neuron apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of endothelial cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within protein localization	ISO Inferred from Sequence Orthology more info
involved_in receptor-mediated endocytosis	ISO Inferred from Sequence Orthology more info
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in smoothened signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in synapse organization	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in axon	IBA Inferred from Biological aspect of Ancestor more info
located_in basement membrane	ISO Inferred from Sequence Orthology more info
located_in basement membrane	TAS Traceable Author Statement more info	PubMed
located_in collagen-containing extracellular matrix	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in extracellular matrix	ISO Inferred from Sequence Orthology more info
located_in extracellular region	IEA Inferred from Electronic Annotation more info
is_active_in neuronal cell body	IBA Inferred from Biological aspect of Ancestor more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: basement membrane-specific heparan sulfate proteoglycan core protein

Names: perlecan (heparan sulfate proteoglycan 2)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001427438.1 → NP_001414367.1 basement membrane-specific heparan sulfate proteoglycan core protein precursor

Status: VALIDATED

Source sequence(s)

JAXUCZ010000005

Related

ENSRNOP00000097780.1, ENSRNOT00000105209.2

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086023.1 Reference GRCr8

Range

154960818..155061971

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039111301.2 → XP_038967229.1 basement membrane-specific heparan sulfate proteoglycan core protein isoform X1

UniProtKB/TrEMBL

A0A8I6ASH2

Conserved Domains (19) summary

cd05743
Location:437 → 514

Ig_Perlecan_like; Immunoglobulin (Ig)-like domain of the human basement membrane heparan sulfate proteoglycan perlecan and similar proteins

smart00192
Location:301 → 332

LDLa; Low-density lipoprotein receptor domain class A

smart00408
Location:2802 → 2861

IGc2; Immunoglobulin C-2 Type

smart00281
Location:606 → 732

LamB; Laminin B domain

smart00409
Location:2602 → 2679

IG; Immunoglobulin

smart00410
Location:1841 → 1921

IG_like; Immunoglobulin like

cd00054
Location:4003 → 4036

EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...

cd00055
Location:1174 → 1223

EGF_Lam; Laminin-type epidermal growth factor-like domain; laminins are the major noncollagenous components of basement membranes that mediate cell adhesion, growth migration, and differentiation; the laminin-type epidermal growth factor-like module occurs in ...

cd00110
Location:4089 → 4238

LamG; Laminin G domain; Laminin G-like domains are usually Ca++ mediated receptors that can have binding sites for steroids, beta1 integrins, heparin, sulfatides, fibulin-1, and alpha-dystroglycans. Proteins that contain LamG domains serve a variety of ...

cd00112
Location:384 → 419

LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...

pfam00008
Location:4263 → 4293

EGF; EGF-like domain

pfam00052
Location:1006 → 1140

Laminin_B; Laminin B (Domain IV)

pfam00053
Location:1291 → 1338

Laminin_EGF; Laminin EGF domain

pfam07679
Location:3731 → 3813

I-set; Immunoglobulin I-set domain

pfam13927
Location:3367 → 3437

Ig_3; Immunoglobulin domain

cd00096
Location:3662 → 3722

Ig; Immunoglobulin domain

cd05754
Location:1929 → 2014

IgI_Perlecan_like; Immunoglobulin (Ig)-like domain found in Perlecan and similar proteins; member of the I-set of Ig superfamily (IgSF) domains

cl02507
Location:80 → 194

SEA; SEA domain

cl11960
Location:3560 → 3638

Ig; Immunoglobulin domain
XM_063287775.1 → XP_063143845.1 basement membrane-specific heparan sulfate proteoglycan core protein isoform X3

UniProtKB/TrEMBL

A0A8I6A2S5

Related

ENSRNOP00000086030.1, ENSRNOT00000098496.2
XM_063287774.1 → XP_063143844.1 basement membrane-specific heparan sulfate proteoglycan core protein isoform X2
XM_063287776.1 → XP_063143846.1 basement membrane-specific heparan sulfate proteoglycan core protein isoform X4