Cct2 chaperonin containing TCP1 subunit 2 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cct2provided by RGD
Official Full Name: chaperonin containing TCP1 subunit 2provided by RGD
Primary source: RGD:1359143
See related: EnsemblRapid:ENSRNOG00000021317 AllianceGenome:RGD:1359143
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Predicted to enable protein folding chaperone; ubiquitin protein ligase binding activity; and unfolded protein binding activity. Predicted to be involved in several processes, including chaperone mediated protein folding independent of cofactor; positive regulation of protein localization to Cajal body; and positive regulation of telomerase RNA localization to Cajal body. Predicted to act upstream of with a positive effect on scaRNA localization to Cajal body. Predicted to act upstream of or within binding activity of sperm to zona pellucida and chaperone-mediated protein complex assembly. Predicted to be located in cell body; cytosol; and microtubule. Predicted to be part of chaperonin-containing T-complex and zona pellucida receptor complex. Orthologous to human CCT2 (chaperonin containing TCP1 subunit 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Thymus (RPKM 579.9), Heart (RPKM 469.0) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 7q22

Exon count:: 16

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	7	NC_086025.1 (54578654..54591428, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	7	NC_051342.1 (52692725..52705478, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	7	NC_005106.4 (60106532..60122779, complement)

Chromosome 7 - NC_086025.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

WI-19751 (e-PCR)
- UniSTS:82731

MARC_36444-36445:1067884409:1 (e-PCR)
- UniSTS:467131

RH143421 (e-PCR)
- UniSTS:232668

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IEA Inferred from Electronic Annotation more info
enables ATP-dependent protein folding chaperone	IEA Inferred from Electronic Annotation more info
enables protein folding chaperone	ISO Inferred from Sequence Orthology more info
enables ubiquitin protein ligase binding	IEA Inferred from Electronic Annotation more info
enables ubiquitin protein ligase binding	ISO Inferred from Sequence Orthology more info
enables unfolded protein binding	IBA Inferred from Biological aspect of Ancestor more info
enables unfolded protein binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in binding of sperm to zona pellucida	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within binding of sperm to zona pellucida	ISO Inferred from Sequence Orthology more info
involved_in chaperone mediated protein folding independent of cofactor	IEA Inferred from Electronic Annotation more info
involved_in chaperone mediated protein folding independent of cofactor	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein complex assembly	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chaperone-mediated protein complex assembly	ISO Inferred from Sequence Orthology more info
involved_in chaperone-mediated protein folding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein localization to Cajal body	ISO Inferred from Sequence Orthology more info	PubMed
involved_in positive regulation of telomerase RNA localization to Cajal body	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of telomerase RNA localization to Cajal body	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of telomere maintenance via telomerase	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of telomere maintenance via telomerase	ISO Inferred from Sequence Orthology more info
involved_in protein folding	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein folding	IEA Inferred from Electronic Annotation more info
involved_in protein folding	ISO Inferred from Sequence Orthology more info
involved_in protein stabilization	IEA Inferred from Electronic Annotation more info
involved_in protein stabilization	ISO Inferred from Sequence Orthology more info
involved_in scaRNA localization to Cajal body	IEA Inferred from Electronic Annotation more info
acts_upstream_of_positive_effect scaRNA localization to Cajal body	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cell body	IEA Inferred from Electronic Annotation more info
located_in cell body	ISO Inferred from Sequence Orthology more info
part_of chaperonin-containing T-complex	IBA Inferred from Biological aspect of Ancestor more info
part_of chaperonin-containing T-complex	IEA Inferred from Electronic Annotation more info
part_of chaperonin-containing T-complex	ISO Inferred from Sequence Orthology more info
part_of chaperonin-containing T-complex	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in microtubule	IEA Inferred from Electronic Annotation more info
located_in microtubule	ISO Inferred from Sequence Orthology more info
part_of zona pellucida receptor complex	IEA Inferred from Electronic Annotation more info
part_of zona pellucida receptor complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: T-complex protein 1 subunit beta

Names: CCT-beta; TCP-1-beta; chaperonin containing TCP1, subunit 2 (beta)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001005905.1 → NP_001005905.1 T-complex protein 1 subunit beta

See identical proteins and their annotated locations for NP_001005905.1

Status: PROVISIONAL

Source sequence(s)

BC083650

UniProtKB/Swiss-Prot

Q5XIM9

UniProtKB/TrEMBL

A0A8I6GLE7, A6IGR4

Related

ENSRNOP00000095994.1, ENSRNOT00000113939.2

Conserved Domains (1) summary

cd03336
Location:11 → 527

TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086025.1 Reference GRCr8

Range

54578654..54591428 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_039078736.2 → XP_038934664.1 T-complex protein 1 subunit beta isoform X1

UniProtKB/TrEMBL

A0A8I6GLE7

Related

ENSRNOP00000029234.5, ENSRNOT00000037946.7

Conserved Domains (1) summary

cd03336
Location:37 → 553

TCP1_beta; TCP-1 (CTT or eukaryotic type II) chaperonin family, beta subunit. Chaperonins are involved in productive folding of proteins. They share a common general morphology, a double toroid of 2 stacked rings. In contrast to bacterial group I chaperonins (GroEL) ...