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Stat3 signal transducer and activator of transcription 3 [ Rattus norvegicus (Norway rat) ]

Gene ID: 25125, updated on 27-Nov-2024

Summary

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Official Symbol: Stat3provided by RGD
Official Full Name: signal transducer and activator of transcription 3provided by RGD
Primary source: RGD:3772
See related: EnsemblRapid:ENSRNOG00000019742 AllianceGenome:RGD:3772
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Summary: Enables CCR5 chemokine receptor binding activity; nuclear glucocorticoid receptor binding activity; and sequence-specific DNA binding activity. Involved in several processes, including negative regulation of hydrogen peroxide biosynthetic process; positive regulation of canonical NF-kappaB signal transduction; and positive regulation of nucleobase-containing compound metabolic process. Acts upstream of or within cellular response to cytokine stimulus and cellular response to organic cyclic compound. Located in cytosol; mitochondrial inner membrane; and nucleus. Is active in Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Used to study several diseases, including duodenal ulcer; hyperuricemia; metabolic dysfunction-associated steatotic liver disease; obesity; and transient cerebral ischemia. Biomarker of atherosclerosis; colon cancer; colorectal carcinoma; heart disease; and pre-malignant neoplasm. Human ortholog(s) of this gene implicated in several diseases, including autoimmune disease (multiple); carcinoma (multiple); hyper IgE recurrent infection syndrome 1; reproductive organ cancer (multiple); and type 2 diabetes mellitus. Orthologous to human STAT3 (signal transducer and activator of transcription 3). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in Heart (RPKM 347.1), Lung (RPKM 285.5) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

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See Stat3 in Genome Data Viewer

Location:: 10q31

Exon count:: 24

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	10	NC_086028.1 (86311528..86363513, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	10	NC_051345.1 (85811206..85863057, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	10	NC_005109.4 (88790401..88842263, complement)

Chromosome 10 - NC_086028.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Role of the JAK2/STAT3 pathway in angiotensin II-induced enhanced expression of Gialpha proteins and hyperproliferation of aortic vascular smooth muscle cells.
Title: Role of the JAK2/STAT3 pathway in angiotensin II-induced enhanced expression of Giα proteins and hyperproliferation of aortic vascular smooth muscle cells.
STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related protein 1) controlled-mitochondrial fission during the development of apoptotic-resistance in pulmonary arterial endothelial cells.
Title: STAT3 phosphorylation at Tyr705 affects DRP1 (dynamin-related protein 1) controlled-mitochondrial fission during the development of apoptotic-resistance in pulmonary arterial endothelial cells.
Daucosterol regulates JAK2-STAT3 signaling pathway to promote megakaryocyte differentiation.
Title: Daucosterol regulates JAK2-STAT3 signaling pathway to promote megakaryocyte differentiation.
Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles promote the recovery of spinal cord injury by affecting the phenotype of astrocytes through the miR-21/JAK2/STAT3 pathway.
Title: Hypoxic-preconditioned mesenchymal stem cell-derived small extracellular vesicles promote the recovery of spinal cord injury by affecting the phenotype of astrocytes through the miR-21/JAK2/STAT3 pathway.
IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway.
Title: IFITM3 mediates inflammation induced myocardial injury through JAK2/STAT3 signaling pathway.
Silencing suppressor of cytokine signaling 3 induces apoptosis and activates the p-STAT3/NF-kappaB pathway in hypoxic cultivated H9c2 cells.
Title: Silencing suppressor of cytokine signaling 3 induces apoptosis and activates the p-STAT3/NF-κB pathway in hypoxic cultivated H9c2 cells.
PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction.
Title: PCSK9 regulates myofibroblast transformation through the JAK2/STAT3 pathway to regulate fibrosis after myocardial infarction.
FOXO1 reduces STAT3 activation and causes impaired mitochondrial quality control in diabetic cardiomyopathy.
Title: FOXO1 reduces STAT3 activation and causes impaired mitochondrial quality control in diabetic cardiomyopathy.
Long noncoding RNA MEG8 induces an imbalance of Th17/Treg cells through the miR-107/STAT3 axis in Henoch-Schonlein purpura rats.
Title: Long noncoding RNA MEG8 induces an imbalance of Th17/Treg cells through the miR-107/STAT3 axis in Henoch-Schonlein purpura rats.
Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes.
Title: Runx1 is upregulated by STAT3 and promotes proliferation of neonatal rat cardiomyocytes.

Submit: New GeneRIF Correction See all GeneRIFs (388)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94819 (e-PCR)
- UniSTS:120065

BF417681 (e-PCR)
- UniSTS:249690

RH143302 (e-PCR)
- UniSTS:232549

PMC303343P1 (e-PCR)
- UniSTS:272501

PMC317074P1 (e-PCR)
- UniSTS:273070

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables CCR5 chemokine receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables DNA binding	ISO Inferred from Sequence Orthology more info
enables DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription activator activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
enables DNA-binding transcription factor activity, RNA polymerase II-specific	IBA Inferred from Biological aspect of Ancestor more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISO Inferred from Sequence Orthology more info
enables DNA-binding transcription factor activity, RNA polymerase II-specific	ISS Inferred from Sequence or Structural Similarity more info
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables RNA sequestering activity	IEA Inferred from Electronic Annotation more info
enables RNA sequestering activity	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	IEA Inferred from Electronic Annotation more info
enables chromatin DNA binding	ISO Inferred from Sequence Orthology more info
enables chromatin DNA binding	ISS Inferred from Sequence or Structural Similarity more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables lncRNA binding	IEA Inferred from Electronic Annotation more info
enables lncRNA binding	ISO Inferred from Sequence Orthology more info
enables nuclear glucocorticoid receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables nuclear receptor activity	IEA Inferred from Electronic Annotation more info
enables nuclear receptor activity	ISO Inferred from Sequence Orthology more info
enables primary miRNA binding	IEA Inferred from Electronic Annotation more info
enables primary miRNA binding	ISO Inferred from Sequence Orthology more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein dimerization activity	ISO Inferred from Sequence Orthology more info
enables protein dimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein homodimerization activity	IEA Inferred from Electronic Annotation more info
enables protein homodimerization activity	ISO Inferred from Sequence Orthology more info
enables protein homodimerization activity	ISS Inferred from Sequence or Structural Similarity more info
enables protein kinase binding	IEA Inferred from Electronic Annotation more info
enables protein kinase binding	ISO Inferred from Sequence Orthology more info
enables protein kinase binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein phosphatase binding	IEA Inferred from Electronic Annotation more info
enables protein phosphatase binding	ISO Inferred from Sequence Orthology more info
enables sequence-specific DNA binding	IDA Inferred from Direct Assay more info	PubMed
enables sequence-specific DNA binding	ISO Inferred from Sequence Orthology more info
enables signaling adaptor activity	IEA Inferred from Electronic Annotation more info
enables signaling adaptor activity	ISO Inferred from Sequence Orthology more info
enables signaling receptor binding	IEA Inferred from Electronic Annotation more info
enables signaling receptor binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISO Inferred from Sequence Orthology more info
enables transcription cis-regulatory region binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in T-helper 17 cell lineage commitment	IEA Inferred from Electronic Annotation more info
involved_in T-helper 17 cell lineage commitment	ISO Inferred from Sequence Orthology more info
involved_in T-helper 17 cell lineage commitment	ISS Inferred from Sequence or Structural Similarity more info
involved_in T-helper 17 type immune response	ISO Inferred from Sequence Orthology more info
involved_in acute-phase response	IEP Inferred from Expression Pattern more info	PubMed
involved_in astrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in astrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in astrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in cell surface receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway via JAK-STAT	TAS Traceable Author Statement more info	PubMed
involved_in cell surface receptor signaling pathway via STAT	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within cellular response to cytokine stimulus	IDA Inferred from Direct Assay more info	PubMed
involved_in cellular response to hormone stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to interleukin-17	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-17	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leptin stimulus	ISO Inferred from Sequence Orthology more info
involved_in cellular response to leptin stimulus	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cellular response to organic cyclic compound	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response	IBA Inferred from Biological aspect of Ancestor more info
involved_in eating behavior	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within eating behavior	ISO Inferred from Sequence Orthology more info
involved_in eating behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in energy homeostasis	IEA Inferred from Electronic Annotation more info
involved_in energy homeostasis	ISO Inferred from Sequence Orthology more info
involved_in energy homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in eye photoreceptor cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in gene expression	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISO Inferred from Sequence Orthology more info
involved_in glucose homeostasis	ISS Inferred from Sequence or Structural Similarity more info
involved_in growth hormone receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	IEA Inferred from Electronic Annotation more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	ISO Inferred from Sequence Orthology more info
involved_in growth hormone receptor signaling pathway via JAK-STAT	ISS Inferred from Sequence or Structural Similarity more info
involved_in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-10-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-10-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-11-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-11-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-15-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-15-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-2-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-2-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-23-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-23-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-6-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in interleukin-6-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in interleukin-9-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in interleukin-9-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in intracellular receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in intracellular receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leptin-mediated signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in leptin-mediated signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in leptin-mediated signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in leptin-mediated signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in mRNA transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within mRNA transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in modulation of chemical synaptic transmission	EXP Inferred from Experiment more info	PubMed
involved_in modulation of chemical synaptic transmission	IDA Inferred from Direct Assay more info	PubMed
involved_in modulation of chemical synaptic transmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of autophagy	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of cell population proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of cell population proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of glycolytic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of glycolytic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of hydrogen peroxide biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of inflammatory response to wounding	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response to wounding	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of neuron migration	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of neuron migration	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of primary miRNA processing	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of primary miRNA processing	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of stem cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of stem cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	IEA Inferred from Electronic Annotation more info
involved_in phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISO Inferred from Sequence Orthology more info
involved_in phosphorylation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of ATP biosynthetic process	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Notch signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of Notch signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of Notch signaling pathway	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of angiogenesis	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of angiogenesis	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of canonical NF-kappaB signal transduction	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of cell migration	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cell migration	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell population proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokine production involved in inflammatory response	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of cytokine production involved in inflammatory response	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of erythrocyte differentiation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of erythrocyte differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of growth factor dependent skeletal muscle satellite cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-1 beta production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-1 beta production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of interleukin-10 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
acts_upstream_of positive regulation of interleukin-6 production	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of interleukin-8 production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of interleukin-8 production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of metalloendopeptidase activity	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of miRNA transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of miRNA transcription	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of tumor necrosis factor production	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of tumor necrosis factor production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of vascular endothelial cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of vascular endothelial growth factor production	IEA Inferred from Electronic Annotation more info
acts_upstream_of positive regulation of vascular endothelial growth factor production	ISO Inferred from Sequence Orthology more info
involved_in postsynapse to nucleus signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in postsynapse to nucleus signaling pathway	IEP Inferred from Expression Pattern more info	PubMed
involved_in protein import into nucleus	IEA Inferred from Electronic Annotation more info
involved_in protein import into nucleus	ISO Inferred from Sequence Orthology more info
involved_in protein import into nucleus	ISS Inferred from Sequence or Structural Similarity more info
involved_in radial glial cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in radial glial cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in radial glial cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	ISO Inferred from Sequence Orthology more info
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell cycle	IEA Inferred from Electronic Annotation more info
involved_in regulation of cell cycle	ISO Inferred from Sequence Orthology more info
involved_in regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of cell population proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of cellular response to hypoxia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of feeding behavior	IEA Inferred from Electronic Annotation more info
involved_in regulation of feeding behavior	ISO Inferred from Sequence Orthology more info
involved_in regulation of feeding behavior	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of mitochondrial membrane permeability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of multicellular organism growth	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within regulation of multicellular organism growth	ISO Inferred from Sequence Orthology more info
involved_in regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to cytokine	IDA Inferred from Direct Assay more info	PubMed
involved_in response to estradiol	IEA Inferred from Electronic Annotation more info
involved_in response to estradiol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to estradiol	ISO Inferred from Sequence Orthology more info
involved_in response to ethanol	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to hypoxia	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to ischemia	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to leptin	ISO Inferred from Sequence Orthology more info
involved_in response to leptin	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to organic cyclic compound	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to peptide hormone	IBA Inferred from Biological aspect of Ancestor more info
involved_in response to peptide hormone	IEP Inferred from Expression Pattern more info	PubMed
involved_in response to xenobiotic stimulus	IEP Inferred from Expression Pattern more info	PubMed
involved_in retinal rod cell differentiation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within retinal rod cell differentiation	ISO Inferred from Sequence Orthology more info
involved_in sexual reproduction	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within sexual reproduction	ISO Inferred from Sequence Orthology more info
involved_in sexual reproduction	ISS Inferred from Sequence or Structural Similarity more info
involved_in somatic stem cell population maintenance	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within somatic stem cell population maintenance	ISO Inferred from Sequence Orthology more info
involved_in temperature homeostasis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within temperature homeostasis	ISO Inferred from Sequence Orthology more info
involved_in temperature homeostasis	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in transforming growth factor beta receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in transforming growth factor beta receptor signaling pathway	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
part_of RNA polymerase II transcription regulator complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase II transcription regulator complex	IEA Inferred from Electronic Annotation more info
part_of RNA polymerase II transcription regulator complex	ISO Inferred from Sequence Orthology more info
is_active_in Schaffer collateral - CA1 synapse	EXP Inferred from Experiment more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in Schaffer collateral - CA1 synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in chromatin	IEA Inferred from Electronic Annotation more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
is_active_in glutamatergic synapse	EXP Inferred from Experiment more info	PubMed
is_active_in glutamatergic synapse	IDA Inferred from Direct Assay more info	PubMed
is_active_in glutamatergic synapse	IMP Inferred from Mutant Phenotype more info	PubMed
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISS Inferred from Sequence or Structural Similarity more info
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
is_active_in postsynaptic density	IDA Inferred from Direct Assay more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
part_of transcription regulator complex	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: signal transducer and activator of transcription 3

Names: signal transducer and activator of transcription 3 (acute-phase response factor)

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001430046.1 → NP_001416975.1 signal transducer and activator of transcription 3 isoform 2

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_001430047.1 → NP_001416976.1 signal transducer and activator of transcription 3 isoform 3

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_001430048.1 → NP_001416977.1 signal transducer and activator of transcription 3 isoform 4

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010
NM_012747.3 → NP_036879.1 signal transducer and activator of transcription 3 isoform 1

See identical proteins and their annotated locations for NP_036879.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000010

UniProtKB/Swiss-Prot

P52631

UniProtKB/TrEMBL

A0A8I6GJJ3, A6HJ64

Related

ENSRNOP00000026760.3, ENSRNOT00000026760.6

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086028.1 Reference GRCr8

Range

86311528..86363513 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006247257.5 → XP_006247319.1 signal transducer and activator of transcription 3 isoform X1

Conserved Domains (4) summary

cd10374
Location:554 → 714

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
XM_006247259.5 → XP_006247321.1 signal transducer and activator of transcription 3 isoform X3

Conserved Domains (4) summary

cd10374
Location:554 → 714

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)
XM_006247258.5 → XP_006247320.1 signal transducer and activator of transcription 3 isoform X2

Conserved Domains (4) summary

cd10374
Location:554 → 715

SH2_STAT3; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 3 proteins

smart00964
Location:2 → 120

STAT_int; STAT protein, protein interaction domain

cd16853
Location:139 → 318

STAT3_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 3 (STAT3)

cd16847
Location:321 → 484

STAT3_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 3 (STAT3)