Me1 malic enzyme 1 [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Me1provided by RGD
Official Full Name: malic enzyme 1provided by RGD
Primary source: RGD:3074
See related: EnsemblRapid:ENSRNOG00000009715 AllianceGenome:RGD:3074
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: MOD1
Summary: Enables NADP binding activity and malate dehydrogenase (decarboxylating) (NADP+) activity. Involved in response to hormone. Located in cytosol and mitochondrion. Orthologous to human ME1 (malic enzyme 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Adrenal (RPKM 685.9), Muscle (RPKM 322.4) and 7 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 8q31

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	8	NC_086026.1 (96429057..96540244, complement)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	8	NC_051343.1 (87549043..87660251, complement)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	8	NC_005107.4 (94256830..94368834, complement)

Chromosome 8 - NC_086026.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

although ME1 overexpression augments anaplerosis and glucose stimulated insulin secretion in INS-1 832/13 cells, it is not likely involved in methyl succinate and glucose stimulated insulin secretion in pancreatic islets
Title: Role for malic enzyme, pyruvate carboxylation, and mitochondrial malate import in glucose-stimulated insulin secretion.
cytosolic or mitochondrial isoforms of malic enzyme do not affect glucose-stimulated insulin secretion from rodent islets
Title: Silencing of cytosolic or mitochondrial isoforms of malic enzyme has no effect on glucose-stimulated insulin secretion from rodent islets.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH94870 (e-PCR)
- UniSTS:120116

RH130391 (e-PCR)
- UniSTS:213675

ME1 (e-PCR)
- UniSTS:266164

RH129138 (e-PCR)
- UniSTS:212446

AU048158 (e-PCR)
- UniSTS:109814

Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables NAD binding	IEA Inferred from Electronic Annotation more info
enables NADP binding	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IEA Inferred from Electronic Annotation more info
enables identical protein binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	IEA Inferred from Electronic Annotation more info
enables magnesium ion binding	ISO Inferred from Sequence Orthology more info
enables magnesium ion binding	ISS Inferred from Sequence or Structural Similarity more info
enables malate dehydrogenase (decarboxylating) (NADP+) activity	IBA Inferred from Biological aspect of Ancestor more info
enables malate dehydrogenase (decarboxylating) (NADP+) activity	IDA Inferred from Direct Assay more info	PubMed
enables malate dehydrogenase (decarboxylating) (NADP+) activity	IEA Inferred from Electronic Annotation more info
enables malate dehydrogenase (decarboxylating) (NADP+) activity	ISO Inferred from Sequence Orthology more info
enables malate dehydrogenase (decarboxylating) (NADP+) activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables malic enzyme activity	IDA Inferred from Direct Assay more info	PubMed
enables malic enzyme activity	IEA Inferred from Electronic Annotation more info
enables malic enzyme activity	ISO Inferred from Sequence Orthology more info
enables malic enzyme activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables manganese ion binding	IEA Inferred from Electronic Annotation more info
enables manganese ion binding	ISO Inferred from Sequence Orthology more info
enables manganese ion binding	ISS Inferred from Sequence or Structural Similarity more info	PubMed
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables oxaloacetate decarboxylase activity	IEA Inferred from Electronic Annotation more info
enables oxaloacetate decarboxylase activity	ISO Inferred from Sequence Orthology more info
enables oxaloacetate decarboxylase activity	ISS Inferred from Sequence or Structural Similarity more info
enables oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in NADH metabolic process	IEA Inferred from Electronic Annotation more info
involved_in NADH metabolic process	ISO Inferred from Sequence Orthology more info
involved_in NADP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in NADP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in malate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in malate metabolic process	IEA Inferred from Electronic Annotation more info
involved_in malate metabolic process	ISO Inferred from Sequence Orthology more info
involved_in malate metabolic process	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in protein homotetramerization	IEA Inferred from Electronic Annotation more info
involved_in protein homotetramerization	ISO Inferred from Sequence Orthology more info
involved_in protein homotetramerization	ISS Inferred from Sequence or Structural Similarity more info
involved_in pyruvate metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in regulation of NADP metabolic process	IEA Inferred from Electronic Annotation more info
involved_in regulation of NADP metabolic process	ISO Inferred from Sequence Orthology more info
involved_in response to hormone	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IDA Inferred from Direct Assay more info	PubMed
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: NADP-dependent malic enzyme

Names: NADP-ME; cytosolic malic enzyme 1; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+); malic enzyme 1, NADP(+)-dependent, cytosolic; malic enzyme 1, soluble

NP_036732.3

EC 1.1.1.40

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_012600.3 → NP_036732.3 NADP-dependent malic enzyme

Status: VALIDATED

Source sequence(s)

JAXUCZ010000008

UniProtKB/Swiss-Prot

P13697

Related

ENSRNOP00000013244.8, ENSRNOT00000013244.8

Conserved Domains (1) summary

PLN03129
Location:11 → 551

PLN03129; NADP-dependent malic enzyme; Provisional