U.S. flag

An official website of the United States government

Links from GEO Profiles

    • Showing Current items.

    BRSK2 BR serine/threonine kinase 2 [ Homo sapiens (human) ]

    Gene ID: 9024, updated on 4-Jan-2025

    Summary

    Official Symbol
    BRSK2provided by HGNC
    Official Full Name
    BR serine/threonine kinase 2provided by HGNC
    Primary source
    HGNC:HGNC:11405
    See related
    Ensembl:ENSG00000174672 MIM:609236; AllianceGenome:HGNC:11405
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SAD1; SADA; SAD-A; STK29; PEN11B; C11orf7
    Summary
    Enables several functions, including ATP binding activity; ATPase binding activity; and magnesium ion binding activity. Involved in several processes, including G2/M transition of mitotic cell cycle; intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress; and regulation of insulin secretion involved in cellular response to glucose stimulus. Located in centrosome and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Biased expression in brain (RPKM 8.8), pancreas (RPKM 3.6) and 2 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BRSK2 in Genome Data Viewer
    Location:
    11p15.5
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (1389934..1462689)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (1461201..1537121)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (1411164..1483919)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902606 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1369804-1370356 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1374637-1375384 Neighboring gene long intergenic non-protein coding RNA 2689 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1380465-1380966 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1380967-1381466 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3054 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:1405373-1405546 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3055 Neighboring gene MPRA-validated peak1160 silencer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1458078-1458816 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1469339-1469838 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1474249-1474958 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1479210-1479772 Neighboring gene MOB kinase activator 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1520757-1521279 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:1528327-1529160 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:1529995-1530826 Neighboring gene uncharacterized LOC124902607

    Genomic regions, transcripts, and products

    Expression

    • Project title: Tissue-specific circular RNA induction during human fetal development
    • Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
    • BioProject: PRJNA270632
    • Publication: PMID 26076956
    • Analysis date: Mon Apr 2 22:54:59 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    BioGRID CRISPR Screen Phenotypes (15 hits/1288 screens)

    EBI GWAS Catalog

    Description
    Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    General gene information

    Clone Names

    • FLJ41362

    Gene Ontology Provided by GOA

    Items 1 - 25 of 35
    Function Evidence Code Pubs
    enables 3-phosphoinositide-dependent protein kinase activity  
    enables AMP-activated protein kinase activity  
    enables ATP binding PubMed 
    enables ATPase binding PubMed 
    enables ATPase regulator activity PubMed 
    enables DNA-dependent protein kinase activity  
    enables Rho-dependent protein serine/threonine kinase activity  
    enables eukaryotic translation initiation factor 2alpha kinase activity  
    enables histone H2AS1 kinase activity  
    enables histone H2AS121 kinase activity  
    enables histone H2AT120 kinase activity  
    enables histone H2AXS139 kinase activity  
    enables histone H2BS14 kinase activity  
    enables histone H2BS36 kinase activity  
    enables histone H3S10 kinase activity  
    enables histone H3S28 kinase activity  
    enables histone H3S57 kinase activity  
    enables histone H3T11 kinase activity  
    enables histone H3T3 kinase activity  
    enables histone H3T45 kinase activity  
    enables histone H3T6 kinase activity  
    enables histone H4S1 kinase activity  
    enables magnesium ion binding PubMed 
    enables protein binding PubMed 
    enables protein kinase binding  
    enables protein serine kinase activity  
    enables protein serine/threonine kinase activity  
    enables protein serine/threonine kinase activity PubMed 
    enables protein serine/threonine kinase activity  
    enables ribosomal protein S6 kinase activity  
    enables tau protein binding PubMed 
    enables tau-protein kinase activity  
    enables tau-protein kinase activity PubMed 
    enables tau-protein kinase activity  
    enables tau-protein kinase activity PubMed 
    Items 1 - 25 of 35
    Process Evidence Code Pubs
    involved_in ERAD pathway PubMed 
    involved_in G2/M transition of mitotic cell cycle  
    involved_in G2/M transition of mitotic cell cycle PubMed 
    involved_in actin cytoskeleton organization PubMed 
    involved_in axonogenesis  
    involved_in axonogenesis  
    involved_in cell division  
    involved_in chromatin remodeling  
    involved_in establishment of cell polarity  
    involved_in establishment of cell polarity  
    involved_in exocytosis  
    involved_in intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress PubMed 
    involved_in microtubule cytoskeleton organization involved in establishment of planar polarity  
    involved_in mitotic cell cycle checkpoint signaling  
    involved_in neuron differentiation  
    involved_in protein phosphorylation PubMed 
    involved_in regulation of ATP-dependent activity PubMed 
    involved_in regulation of axonogenesis  
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus  
    involved_in regulation of neuron projection development  
    involved_in regulation of retrograde protein transport, ER to cytosol PubMed 
    involved_in regulation of retrograde protein transport, ER to cytosol PubMed 
    involved_in regulation of synaptic vesicle clustering PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome  
    located_in centrosome PubMed 
    located_in cytoplasm PubMed 
    located_in distal axon  
    located_in endoplasmic reticulum PubMed 
    located_in perinuclear region of cytoplasm  

    General protein information

    Preferred Names
    serine/threonine-protein kinase BRSK2
    Names
    BR serine/threonine-protein kinase 2
    brain-selective kinase 2
    brain-specific serine/threonine-protein kinase 2
    protein kinase SAD1B
    serine/threonine-protein kinase 29
    serine/threonine-protein kinase SAD-A
    testicular tissue protein Li 30
    NP_001243556.1
    NP_001243558.1
    NP_001243559.1
    NP_001269147.1
    NP_003948.2
    XP_005253275.1
    XP_006718437.1
    XP_006718439.1
    XP_011518763.1
    XP_011518764.1
    XP_016874021.1
    XP_016874022.1
    XP_016874023.1
    XP_016874024.1
    XP_016874025.1
    XP_016874026.1
    XP_047283806.1
    XP_047283807.1
    XP_047283808.1
    XP_047283809.1
    XP_047283810.1
    XP_054189097.1
    XP_054189098.1
    XP_054189099.1
    XP_054189100.1
    XP_054189101.1
    XP_054189102.1
    XP_054189103.1
    XP_054189104.1
    XP_054189105.1
    XP_054189106.1
    XP_054189107.1
    XP_054189108.1
    XP_054189109.1
    XP_054189110.1
    XP_054189111.1
    XP_054189112.1
    XP_054226408.1
    XP_054226409.1
    XP_054226410.1
    XP_054226411.1
    XP_054226412.1
    XP_054226413.1
    XP_054226414.1
    XP_054226415.1
    XP_054226416.1
    XP_054226417.1
    XP_054226418.1
    XP_054226419.1
    XP_054226420.1
    XP_054226421.1
    XP_054226422.1
    XP_054226423.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001256627.2 → NP_001243556.1  serine/threonine-protein kinase BRSK2 isoform 1

      See identical proteins and their annotated locations for NP_001243556.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes isoform 1.
      Source sequence(s)
      AC091196, AC136297, AF533879, AK131534
      Consensus CDS
      CCDS58107.1
      UniProtKB/Swiss-Prot
      B3KVE9, E9PLM7, O60843, O95099, Q5J5B4, Q6ZMQ4, Q8IWQ3, Q8TB60
      Related
      ENSP00000432000.1, ENST00000528841.6
      Conserved Domains (3) summary
      smart00220
      Location:19 → 269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14340
      Location:297 → 350
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:17 → 270
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    2. NM_001256629.2 → NP_001243558.1  serine/threonine-protein kinase BRSK2 isoform 3

      See identical proteins and their annotated locations for NP_001243558.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and contains an alternate exon in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (3) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC091196, AC136297, AF533877, AK131534
      Consensus CDS
      CCDS58106.1
      Related
      ENSP00000431152.1, ENST00000531197.5
      Conserved Domains (2) summary
      cd14340
      Location:297 → 350
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:17 → 270
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    3. NM_001256630.1 → NP_001243559.1  serine/threonine-protein kinase BRSK2 isoform 4

      See identical proteins and their annotated locations for NP_001243559.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, initiates translation at an alternate start codon and uses an alternate splice site in the 3' coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (4) is longer and has a distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AC091196, AK131534
      Consensus CDS
      CCDS58108.1
      UniProtKB/Swiss-Prot
      Q8IWQ3
      Related
      ENSP00000371614.1, ENST00000382179.5
      Conserved Domains (3) summary
      smart00220
      Location:77 → 315
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14340
      Location:343 → 396
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:62 → 316
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    4. NM_001282218.2 → NP_001269147.1  serine/threonine-protein kinase BRSK2 isoform 5

      See identical proteins and their annotated locations for NP_001269147.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (6) differs in both UTRs and has multiple differences in the coding region, one of which results in a translational frameshift, compared to variant 1. The resulting protein (isoform 5) has a shorter N-terminus and a distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AC091196, AK122851, AK297211
      Consensus CDS
      CCDS60696.1
      UniProtKB/Swiss-Prot
      Q8IWQ3
      UniProtKB/TrEMBL
      B4DLY3
      Related
      ENSP00000433235.1, ENST00000528710.5
      Conserved Domains (2) summary
      cd14340
      Location:237 → 290
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:1 → 210
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    5. NM_003957.4 → NP_003948.2  serine/threonine-protein kinase BRSK2 isoform 2

      See identical proteins and their annotated locations for NP_003948.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, which results in a frameshift, compared to variant 1. The encoded isoform (2) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AC091196, AC136297, AY166857, DA059153
      Consensus CDS
      CCDS41590.1
      UniProtKB/TrEMBL
      A0A140VJF6
      Related
      ENSP00000310697.9, ENST00000308219.13
      Conserved Domains (2) summary
      cd14340
      Location:297 → 350
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:17 → 270
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2

    RNA

    1. NR_046331.2 RNA Sequence

      Status: VALIDATED

      Description
      Transcript Variant: This variant (5) contains two alternate exons in the 3' region, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC091196, AC136297, AF533880, AK131534

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      1389934..1462689
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017018533.2 → XP_016874022.1  serine/threonine-protein kinase BRSK2 isoform X1

    2. XM_047427850.1 → XP_047283806.1  serine/threonine-protein kinase BRSK2 isoform X3

    3. XM_006718374.3 → XP_006718437.1  serine/threonine-protein kinase BRSK2 isoform X5

      Conserved Domains (3) summary
      smart00220
      Location:19 → 269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14340
      Location:297 → 350
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:17 → 270
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    4. XM_017018536.2 → XP_016874025.1  serine/threonine-protein kinase BRSK2 isoform X2

    5. XM_047427851.1 → XP_047283807.1  serine/threonine-protein kinase BRSK2 isoform X4

    6. XM_005253218.4 → XP_005253275.1  serine/threonine-protein kinase BRSK2 isoform X6

      Conserved Domains (3) summary
      smart00220
      Location:19 → 269
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14340
      Location:297 → 350
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:17 → 270
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    7. XM_017018532.2 → XP_016874021.1  serine/threonine-protein kinase BRSK2 isoform X7

    8. XM_017018534.2 → XP_016874023.1  serine/threonine-protein kinase BRSK2 isoform X8

    9. XM_017018537.2 → XP_016874026.1  serine/threonine-protein kinase BRSK2 isoform X10

    10. XM_006718376.3 → XP_006718439.1  serine/threonine-protein kinase BRSK2 isoform X11

      See identical proteins and their annotated locations for XP_006718439.1

      Conserved Domains (3) summary
      smart00220
      Location:2 → 209
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14340
      Location:237 → 290
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:1 → 210
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    11. XM_047427852.1 → XP_047283808.1  serine/threonine-protein kinase BRSK2 isoform X12

    12. XM_047427853.1 → XP_047283809.1  serine/threonine-protein kinase BRSK2 isoform X15

    13. XM_017018535.2 → XP_016874024.1  serine/threonine-protein kinase BRSK2 isoform X9

    14. XM_011520461.3 → XP_011518763.1  serine/threonine-protein kinase BRSK2 isoform X13

      Conserved Domains (3) summary
      smart00220
      Location:2 → 209
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14340
      Location:237 → 290
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:1 → 210
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    15. XM_011520462.3 → XP_011518764.1  serine/threonine-protein kinase BRSK2 isoform X14

      Conserved Domains (3) summary
      smart00220
      Location:2 → 209
      S_TKc; Serine/Threonine protein kinases, catalytic domain
      cd14340
      Location:237 → 290
      UBA_BRSK; UBA domain found in serine/threonine-protein kinase BRSK1, BRSK2 and similar proteins
      cd14081
      Location:1 → 210
      STKc_BRSK1_2; Catalytic domain of Brain-specific serine/threonine-protein kinases 1 and 2
    16. XM_047427854.1 → XP_047283810.1  serine/threonine-protein kinase BRSK2 isoform X16

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791792.1 Reference GRCh38.p14 PATCHES

      Range
      124200..196955
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333123.1 → XP_054189098.1  serine/threonine-protein kinase BRSK2 isoform X1

    2. XM_054333128.1 → XP_054189103.1  serine/threonine-protein kinase BRSK2 isoform X3

    3. XM_054333131.1 → XP_054189106.1  serine/threonine-protein kinase BRSK2 isoform X5

    4. XM_054333126.1 → XP_054189101.1  serine/threonine-protein kinase BRSK2 isoform X2

    5. XM_054333129.1 → XP_054189104.1  serine/threonine-protein kinase BRSK2 isoform X4

    6. XM_054333135.1 → XP_054189110.1  serine/threonine-protein kinase BRSK2 isoform X6

    7. XM_054333122.1 → XP_054189097.1  serine/threonine-protein kinase BRSK2 isoform X17

    8. XM_054333124.1 → XP_054189099.1  serine/threonine-protein kinase BRSK2 isoform X18

    9. XM_054333125.1 → XP_054189100.1  serine/threonine-protein kinase BRSK2 isoform X19

    10. XM_054333127.1 → XP_054189102.1  serine/threonine-protein kinase BRSK2 isoform X20

    11. XM_054333130.1 → XP_054189105.1  serine/threonine-protein kinase BRSK2 isoform X21

    12. XM_054333132.1 → XP_054189107.1  serine/threonine-protein kinase BRSK2 isoform X22

    13. XM_054333133.1 → XP_054189108.1  serine/threonine-protein kinase BRSK2 isoform X23

    14. XM_054333134.1 → XP_054189109.1  serine/threonine-protein kinase BRSK2 isoform X24

    15. XM_054333136.1 → XP_054189111.1  serine/threonine-protein kinase BRSK2 isoform X25

    16. XM_054333137.1 → XP_054189112.1  serine/threonine-protein kinase BRSK2 isoform X26

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      1461201..1537121
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054370434.1 → XP_054226409.1  serine/threonine-protein kinase BRSK2 isoform X1

    2. XM_054370439.1 → XP_054226414.1  serine/threonine-protein kinase BRSK2 isoform X3

    3. XM_054370442.1 → XP_054226417.1  serine/threonine-protein kinase BRSK2 isoform X5

    4. XM_054370437.1 → XP_054226412.1  serine/threonine-protein kinase BRSK2 isoform X2

    5. XM_054370440.1 → XP_054226415.1  serine/threonine-protein kinase BRSK2 isoform X4

    6. XM_054370446.1 → XP_054226421.1  serine/threonine-protein kinase BRSK2 isoform X6

    7. XM_054370433.1 → XP_054226408.1  serine/threonine-protein kinase BRSK2 isoform X27

    8. XM_054370435.1 → XP_054226410.1  serine/threonine-protein kinase BRSK2 isoform X28

    9. XM_054370436.1 → XP_054226411.1  serine/threonine-protein kinase BRSK2 isoform X29

    10. XM_054370438.1 → XP_054226413.1  serine/threonine-protein kinase BRSK2 isoform X30

    11. XM_054370441.1 → XP_054226416.1  serine/threonine-protein kinase BRSK2 isoform X31

    12. XM_054370443.1 → XP_054226418.1  serine/threonine-protein kinase BRSK2 isoform X32

    13. XM_054370444.1 → XP_054226419.1  serine/threonine-protein kinase BRSK2 isoform X33

    14. XM_054370445.1 → XP_054226420.1  serine/threonine-protein kinase BRSK2 isoform X34

    15. XM_054370447.1 → XP_054226422.1  serine/threonine-protein kinase BRSK2 isoform X35

    16. XM_054370448.1 → XP_054226423.1  serine/threonine-protein kinase BRSK2 isoform X36

    External link. Please review our privacy policy.