PRAC1 PRAC1 small nuclear protein [Homo sapiens (human)] - Gene

Summary

Official Symbol: PRAC1provided by HGNC
Official Full Name: PRAC1 small nuclear proteinprovided by HGNC
Primary source: HGNC:HGNC:30591
See related: Ensembl:ENSG00000159182 MIM:609819; AllianceGenome:HGNC:30591
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: PRAC; C17orf92
Summary: This gene is reported to be specifically expressed in prostate, rectum and distal colon. Sequence analysis suggests that it may play a regulatory role in the nucleus. [provided by RefSeq, Jul 2008]
Expression: Biased expression in colon (RPKM 46.5) and prostate (RPKM 34.0) See more
Orthologs: all
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Genomic context

Location:: 17q21.32

Exon count:: 2

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	17	NC_000017.11 (48721719..48722518, complement)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	17	NC_060941.1 (49585320..49586119, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	17	NC_000017.10 (46799081..46799880, complement)

Chromosome 17 - NC_000017.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Tissue-specific circular RNA induction during human fetal development
Description: 35 human fetal samples from 6 tissues (3 - 7 replicates per tissue) collected between 10 and 20 weeks gestational time were sequenced using Illumina TruSeq Stranded Total RNA
BioProject: PRJNA270632
Publication: PMID 26076956
Analysis date: Mon Apr 2 22:54:59 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Discovering the molecular differences between right- and left-sided colon cancer using machine learning methods.
Title: Discovering the molecular differences between right- and left-sided colon cancer using machine learning methods.
Enhanced methylation of PRAC was positively associated with a high rate of recurrence and progression in nonmuscle invasive bladder cancer patients.
Title: Clinical Implications and Prognostic Values of Prostate Cancer Susceptibility Candidate Methylation in Primary Nonmuscle Invasive Bladder Cancer.
the pathogenesis of prostate cancer may be due to the expression levels of PRAC protein, and this protein can serve as a potential biomarker for the management of prostate cancer.
Title: Aberrant expression of the PRAC gene in prostate cancer.

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Phenotypes

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Review eQTL and phenotype association data in this region using PheGenI

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

General gene information

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Gene Ontology Provided by GOA

Component	Evidence Code	Pubs
located_in cytosol	IDA Inferred from Direct Assay more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info

General protein information

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Preferred Names: small nuclear protein PRAC1

Names: prostate cancer susceptibility candidate 1; prostate cancer susceptibility candidate protein 1; prostate, rectum and colon expressed gene protein; small nuclear protein PRAC

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.