Ctf2 cardiotrophin 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ctf2provided by MGI
Official Full Name: cardiotrophin 2provided by MGI
Primary source: MGI:MGI:2684607
See related: Ensembl:ENSMUSG00000060034 AllianceGenome:MGI:2684607
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: NP; Gm494
Summary: Enables ciliary neurotrophic factor receptor binding activity and leukemia inhibitory factor receptor binding activity. Acts upstream of or within positive regulation of neuroblast proliferation. Predicted to be located in extracellular space. Predicted to be active in extracellular region. Is expressed in several structures, including central nervous system; lung; metanephros; neural retinal epithelium; and skin. Orthologous to human CTF2P (cardiotrophin 2, pseudogene). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
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Genomic context

Location:: 7 F3; 7 69.69 cM

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	7	NC_000073.7 (127318132..127324788, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	7	NC_000073.6 (127718960..127725616, complement)

Chromosome 7 - NC_000073.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Neuropoietin induced activation of STAT3 tyrosine phosphorylation in adipocytes is independent of LIFR phosphorylation and degradation.
Title: Neuropoietin activates STAT3 independent of LIFR activation in adipocytes.
Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain
Title: Ciliary neurotrophic factor, cardiotrophin-like cytokine, and neuropoietin share a conserved binding site on the ciliary neurotrophic factor receptor alpha chain.
a new ligand for ciliary neurotrophic factor receptor alpha, with important implications for murine nervous system development
Title: Neuropoietin, a new IL-6-related cytokine signaling through the ciliary neurotrophic factor receptor.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Ctf2 (e-PCR), detects polymorphism
- UniSTS:507987

Ctf2 (e-PCR), detects polymorphism
- UniSTS:507988

NoName (e-PCR)
- UniSTS:493912

C87101 (e-PCR)
- UniSTS:167522

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ciliary neurotrophic factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables cytokine activity	IBA Inferred from Biological aspect of Ancestor more info
enables cytokine activity	IEA Inferred from Electronic Annotation more info
enables leukemia inhibitory factor receptor binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in cell surface receptor signaling pathway via JAK-STAT	IBA Inferred from Biological aspect of Ancestor more info
involved_in nervous system development	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within positive regulation of neuroblast proliferation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in extracellular region	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: cardiotrophin-2

Names: CT-2; neuropoietin

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.