Rpl10 ribosomal protein L10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Rpl10provided by MGI
Official Full Name: ribosomal protein L10provided by MGI
Primary source: MGI:MGI:105943
See related: Ensembl:ENSMUSG00000008682 AllianceGenome:MGI:105943
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: QM; QM16; D0HXS648; DXHXS648; DXHXS648E
Summary: A structural constituent of ribosome. Predicted to be involved in several processes, including embryonic brain development; regulation of gene expression; and translation. Located in cytoplasm. Part of cytosolic large ribosomal subunit. Is active in synapse. Colocalizes with smooth endoplasmic reticulum. Is expressed in several structures, including limb; nervous system; otocyst; skin; and surface ectoderm. Human ortholog(s) of this gene implicated in autistic disorder and syndromic X-linked mental retardation 35. Orthologous to human RPL10 (ribosomal protein L10). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in bladder adult (RPKM 662.4), genital fat pad adult (RPKM 624.3) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: X A7.3; X 37.94 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (73314463..73316741)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (74270816..74273135)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

R98S mutation in RPL10 gene results in elevated expression of JAK-STAT signaling pathway proteins in RPL1-R98S transgenic mouse model of T-cell acute lymphoblastic leukemia.
Title: The T-cell leukemia-associated ribosomal RPL10 R98S mutation enhances JAK-STAT signaling.
A new protein haponin (an HLDF-alike protein) in promyelocyte HL-60 cells was found.
Title: [Identification and expression of haponin, a new protein from HL-60 cells].

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

1110004E09Rik (e-PCR), detects polymorphism
- UniSTS:259013

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables structural constituent of ribosome	IBA Inferred from Biological aspect of Ancestor more info
enables structural constituent of ribosome	IDA Inferred from Direct Assay more info	PubMed
enables structural constituent of ribosome	ISO Inferred from Sequence Orthology more info
enables structural constituent of ribosome	ISS Inferred from Sequence or Structural Similarity more info
enables translation regulator activity	ISO Inferred from Sequence Orthology more info
enables translation regulator activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in embryonic brain development	ISO Inferred from Sequence Orthology more info
involved_in embryonic brain development	ISS Inferred from Sequence or Structural Similarity more info
involved_in liver regeneration	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISO Inferred from Sequence Orthology more info
involved_in regulation of translation	ISS Inferred from Sequence or Structural Similarity more info
involved_in translation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within translation	ISO Inferred from Sequence Orthology more info
involved_in translation at postsynapse	NAS Non-traceable Author Statement more info	PubMed
involved_in translation at presynapse	NAS Non-traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	TAS Traceable Author Statement more info
part_of cytosolic large ribosomal subunit	IBA Inferred from Biological aspect of Ancestor more info
part_of cytosolic large ribosomal subunit	IDA Inferred from Direct Assay more info	PubMed
part_of cytosolic large ribosomal subunit	ISO Inferred from Sequence Orthology more info
part_of cytosolic large ribosomal subunit	ISS Inferred from Sequence or Structural Similarity more info
located_in cytosolic ribosome	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
is_active_in postsynapse	NAS Non-traceable Author Statement more info	PubMed
is_active_in presynapse	NAS Non-traceable Author Statement more info	PubMed
part_of protein-containing complex	ISO Inferred from Sequence Orthology more info
is_active_in ribosome	NAS Non-traceable Author Statement more info	PubMed
colocalizes_with smooth endoplasmic reticulum	IDA Inferred from Direct Assay more info	PubMed
colocalizes_with smooth endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
is_active_in synapse	EXP Inferred from Experiment more info	PubMed
is_active_in synapse	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: large ribosomal subunit protein uL16

Names: 24.6 kDa protein; 24.6kDa protein; 60S ribosomal protein L10; protein QM homolog; ribosomal protein 10

NP_443067.1

EC 3.6.5.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.