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    L3mbtl4 L3MBTL4 histone methyl-lysine binding protein [ Mus musculus (house mouse) ]

    Gene ID: 320858, updated on 27-Nov-2024

    Summary

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    Official Symbol
    L3mbtl4provided by MGI
    Official Full Name
    L3MBTL4 histone methyl-lysine binding proteinprovided by MGI
    Primary source
    MGI:MGI:2444889
    See related
    Ensembl:ENSMUSG00000041565 AllianceGenome:MGI:2444889
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    A730037L19Rik; D930040M24Rik
    Summary
    Predicted to enable chromatin binding activity and histone binding activity. Predicted to be involved in negative regulation of DNA-templated transcription. Predicted to be active in nucleus. Orthologous to human L3MBTL4 (L3MBTL histone methyl-lysine binding protein 4). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See L3mbtl4 in Genome Data Viewer
    Location:
    17 E1.2- E1.3; 17 39.3 cM
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (68579893..69091073)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (68272898..68784078)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43107 Neighboring gene Rho GTPase activating protein 28 Neighboring gene STARR-seq mESC enhancer starr_43108 Neighboring gene STARR-seq mESC enhancer starr_43110 Neighboring gene STARR-seq mESC enhancer starr_43111 Neighboring gene predicted gene, 36252 Neighboring gene predicted gene, 36312 Neighboring gene peroxiredoxin 2 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43112 Neighboring gene nucleophosmin 1 pseudogene Neighboring gene transmembrane protein 200C Neighboring gene predicted gene, 38593 Neighboring gene predicted gene, 36392

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A global genomic transcriptional code associated with CNS-expressed genes. Bailey PJ, et al. Exp Cell Res, 2006 Oct 1. PMID 16919269
    2. GUDMAP: the genitourinary developmental molecular anatomy project. McMahon AP, et al. J Am Soc Nephrol, 2008 Apr. PMID 18287559
    3. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    4. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables histone binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of DNA-templated transcription IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    lethal(3)malignant brain tumor-like protein 4
    Names
    l(3)mbt-like protein 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433415.1 → NP_001420344.1  lethal(3)malignant brain tumor-like protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC117803, AC154758, AC163901, AC191933, CT010483

    2. NM_177278.6 → NP_796252.2  lethal(3)malignant brain tumor-like protein 4 isoform 1

      See identical proteins and their annotated locations for NP_796252.2

      Status: VALIDATED

      Source sequence(s)
      AC117803, AC154493, AC154758, AC163901, AC191933, CT010483
      UniProtKB/Swiss-Prot
      B1B1A0, B2RVB2, Q8BHZ8
      Conserved Domains (4) summary
      cd09582
      Location:540 → 605
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00454
      Location:540 → 607
      SAM; Sterile alpha motif
      smart00561
      Location:273 → 364
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:379 → 405
      zf-C2HC; Zinc finger, C2HC type

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      68579893..69091073
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524417.3 → XP_006524480.1  lethal(3)malignant brain tumor-like protein 4 isoform X1

      See identical proteins and their annotated locations for XP_006524480.1

      UniProtKB/TrEMBL
      A0A0A0MQK6
      Conserved Domains (3) summary
      cd09582
      Location:531 → 596
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:273 → 364
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:379 → 407
      zf-C2HC; Zinc finger, C2HC type

    2. XM_006524416.3 → XP_006524479.1  lethal(3)malignant brain tumor-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQK6
      Related
      ENSMUSP00000121045.3, ENSMUST00000124543.9
      Conserved Domains (3) summary
      cd09582
      Location:531 → 596
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:273 → 364
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:379 → 407
      zf-C2HC; Zinc finger, C2HC type

    3. XM_006524420.2 → XP_006524483.1  lethal(3)malignant brain tumor-like protein 4 isoform X3

      Conserved Domains (4) summary
      cd09582
      Location:376 → 441
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:118 → 209
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:224 → 252
      zf-C2HC; Zinc finger, C2HC type
      pfam02820
      Location:42 → 109
      MBT; mbt repeat

    4. XM_036160648.1 → XP_036016541.1  lethal(3)malignant brain tumor-like protein 4 isoform X1

      UniProtKB/TrEMBL
      A0A0A0MQK6
      Conserved Domains (3) summary
      cd09582
      Location:531 → 596
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:273 → 364
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:379 → 407
      zf-C2HC; Zinc finger, C2HC type

    5. XM_036160649.1 → XP_036016542.1  lethal(3)malignant brain tumor-like protein 4 isoform X3

      Conserved Domains (4) summary
      cd09582
      Location:376 → 441
      SAM_Scm-like-3MBT3,4; SAM domain of Scm-like-3MBT3,4 proteins of Polycomb group
      smart00561
      Location:118 → 209
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:224 → 252
      zf-C2HC; Zinc finger, C2HC type
      pfam02820
      Location:42 → 109
      MBT; mbt repeat

    6. XM_017317505.2 → XP_017172994.1  lethal(3)malignant brain tumor-like protein 4 isoform X2

      Conserved Domains (2) summary
      smart00561
      Location:273 → 364
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:379 → 407
      zf-C2HC; Zinc finger, C2HC type

    7. XM_017317506.2 → XP_017172995.1  lethal(3)malignant brain tumor-like protein 4 isoform X4

      Conserved Domains (2) summary
      smart00561
      Location:273 → 364
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:379 → 404
      zf-C2HC; Zinc finger, C2HC type

    8. XM_030249846.1 → XP_030105706.1  lethal(3)malignant brain tumor-like protein 4 isoform X6

      Conserved Domains (2) summary
      smart00561
      Location:118 → 209
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      pfam01530
      Location:224 → 252
      zf-C2HC; Zinc finger, C2HC type

    9. XM_030249845.1 → XP_030105705.1  lethal(3)malignant brain tumor-like protein 4 isoform X5

      Conserved Domains (2) summary
      smart00561
      Location:55 → 149
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      cl17705
      Location:273 → 327
      MBT; mbt repeat

    10. XM_011246498.3 → XP_011244800.1  lethal(3)malignant brain tumor-like protein 4 isoform X5

      Related
      ENSMUSP00000117626.2, ENSMUST00000139383.8
      Conserved Domains (2) summary
      smart00561
      Location:55 → 149
      MBT; Present in Drosophila Scm, l(3)mbt, and vertebrate SCML2
      cl17705
      Location:273 → 327
      MBT; mbt repeat

    RNA

    1. XR_004939538.1 RNA Sequence

    2. XR_004939539.1 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    B1B1A0.2 GenPept UniProtKB/Swiss-Prot:B1B1A0

    Gene LinkOut

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