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    Zfp654 zinc finger protein 654 [ Mus musculus (house mouse) ]

    Gene ID: 72020, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zfp654provided by MGI
    Official Full Name
    zinc finger protein 654provided by MGI
    Primary source
    MGI:MGI:1919270
    See related
    Ensembl:ENSMUSG00000047141 AllianceGenome:MGI:1919270
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    433036; Gm5488; Znf654; 1600021C16Rik; 1810008K20Rik
    Summary
    Predicted to enable DNA binding activity and DNA-binding transcription factor activity, RNA polymerase II-specific. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. Is expressed in early conceptus; inner cell mass; and oocyte. Orthologous to human ZNF654 (zinc finger protein 654). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in testis adult (RPKM 17.2), bladder adult (RPKM 2.8) and 12 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Zfp654 in Genome Data Viewer
    Location:
    16 C1.3; 16 37.1 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (64600710..64672300, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (64780347..64851937, complement)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene casein kinase 2, alpha prime interacting protein Neighboring gene STARR-seq mESC enhancer starr_41145 Neighboring gene STARR-seq mESC enhancer starr_41146 Neighboring gene RIKEN cDNA 4930453N24 gene Neighboring gene STARR-seq mESC enhancer starr_41148 Neighboring gene STARR-positive B cell enhancer mm9_chr16:64851511-64851812 Neighboring gene STARR-seq mESC enhancer starr_41150 Neighboring gene CGG triplet repeat binding protein 1 Neighboring gene predicted gene, 33971

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Resolution of cell fate decisions revealed by single-cell gene expression analysis from zygote to blastocyst. Guo G, et al. Dev Cell, 2010 Apr 20. PMID 20412781
    2. A systems approach reveals that the myogenesis genome network is regulated by the transcriptional repressor RP58. Yokoyama S, et al. Dev Cell, 2009 Dec. PMID 20059953, Free PMC Article
    3. Database resources of the National Center for Biotechnology Information. Wheeler DL, et al. Nucleic Acids Res, 2001 Jan 1. PMID 11125038, Free PMC Article
    4. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    5. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    zinc finger protein 654

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001347245.1 → NP_001334174.1  zinc finger protein 654

      Status: VALIDATED

      Source sequence(s)
      BC068018, CT030641
      Consensus CDS
      CCDS84250.1
      UniProtKB/Swiss-Prot
      A0A140LI34, Q8K390, Q9DAU9
      Related
      ENSMUSP00000146656.2, ENSMUST00000207826.2
      Conserved Domains (3) summary
      sd00017
      Location:781 → 801
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:541 → 560
      ZF_C2H2; C2H2 Zn finger [structural motif]
      cd20908
      Location:538 → 607
      SUF4-like; N-terminal domain of Oryza sativa transcription factor SUPPRESSOR OF FRI 4 (OsSUF4), Arabidopsis thaliana SUF4 (AtSUF4), and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      64600710..64672300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011246018.3 → XP_011244320.1  zinc finger protein 654 isoform X1

      Conserved Domains (2) summary
      sd00017
      Location:569 → 589
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00019
      Location:329 → 348
      ZF_C2H2; C2H2 Zn finger [structural motif]

    RNA

    1. XR_003951833.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_028059.2: Suppressed sequence

      Description
      NM_028059.2: This RefSeq was removed because it is though to represent a partial transcript.
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9DAU9.3 GenPept UniProtKB/Swiss-Prot:Q9DAU9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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