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    Fzd8 frizzled class receptor 8 [ Mus musculus (house mouse) ]

    Gene ID: 14370, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fzd8provided by MGI
    Official Full Name
    frizzled class receptor 8provided by MGI
    Primary source
    MGI:MGI:108460
    See related
    Ensembl:ENSMUSG00000036904 AllianceGenome:MGI:108460
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Fz8
    Summary
    Enables several functions, including PDZ domain binding activity; Wnt receptor activity; and Wnt-protein binding activity. Involved in Wnt signaling pathway. Acts upstream of or within several processes, including T cell differentiation in thymus; canonical Wnt signaling pathway; and positive regulation of JUN kinase activity. Located in plasma membrane. Part of Wnt-Frizzled-LRP5/6 complex. Is active in neuronal dense core vesicle. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; integumental system; and sensory organ. Orthologous to human FZD8 (frizzled class receptor 8). [provided by Alliance of Genome Resources, Dec 2024]
    Orthologs
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    Genomic context

    See Fzd8 in Genome Data Viewer
    Location:
    18 A1; 18 4.91 cM
    Exon count:
    1
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 18 NC_000084.7 (9212856..9216201)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 18 NC_000084.6 (9212856..9216201)

    Chromosome 18 - NC_000084.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_43767 Neighboring gene NSFL1 (p97) cofactor (p47) pseudogene Neighboring gene STARR-seq mESC enhancer starr_43768 Neighboring gene crumbs homolog 1 pseudogene Neighboring gene STARR-seq mESC enhancer starr_43769 Neighboring gene STARR-seq mESC enhancer starr_43770 Neighboring gene VISTA enhancer mm1632 Neighboring gene STARR-seq mESC enhancer starr_43772 Neighboring gene STARR-seq mESC enhancer starr_43773 Neighboring gene STARR-seq mESC enhancer starr_43774 Neighboring gene gap junction protein, delta 4 Neighboring gene cyclin Y Neighboring gene STARR-positive B cell enhancer ABC_E7573

    Genomic regions, transcripts, and products

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (3) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables PDZ domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt receptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Wnt receptor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ubiquitin protein ligase binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    part_of Wnt-Frizzled-LRP5/6 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of Wnt-Frizzled-LRP5/6 complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in neuronal dense core vesicle EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in neuronal dense core vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    frizzled-8
    Names
    frizzled homolog 8
    fz-8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_008058.2NP_032084.2  frizzled-8 precursor

      See identical proteins and their annotated locations for NP_032084.2

      Status: VALIDATED

      Source sequence(s)
      AC108777, BC132543
      Consensus CDS
      CCDS29048.1
      UniProtKB/Swiss-Prot
      A2RTK9, Q61091
      Related
      ENSMUSP00000039660.6, ENSMUST00000041080.7
      Conserved Domains (2) summary
      cd07461
      Location:31155
      CRD_FZ8; Cysteine-rich Wnt-binding domain (CRD) of the frizzled 8 (Fz8) receptor
      cd15250
      Location:264616
      7tmF_FZD8; class F frizzled subfamily 8, member of 7-transmembrane G protein-coupled receptors

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000084.7 Reference GRCm39 C57BL/6J

      Range
      9212856..9216201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)