Utp18 UTP18 small subunit processome component [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Utp18provided by MGI
Official Full Name: UTP18 small subunit processome componentprovided by MGI
Primary source: MGI:MGI:1923402
See related: Ensembl:ENSMUSG00000054079 AllianceGenome:MGI:1923402
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Wdr50; 6430513M13; 6230425C22Rik
Summary: Predicted to be involved in ribosomal small subunit biogenesis. Predicted to be located in nuclear membrane; nucleolus; and nucleoplasm. Predicted to be part of Pwp2p-containing subcomplex of 90S preribosome and small-subunit processome. Is expressed in heart. Orthologous to human UTP18 (UTP18 small subunit processome component). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in CNS E11.5 (RPKM 9.2), placenta adult (RPKM 6.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 11 D; 11 58.84 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	11	NC_000077.7 (93750069..93776592, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	11	NC_000077.6 (93859243..93885766, complement)

Chromosome 11 - NC_000077.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Process	Evidence Code	Pubs
involved_in rRNA processing	IEA Inferred from Electronic Annotation more info
involved_in ribosomal small subunit biogenesis	ISO Inferred from Sequence Orthology more info
involved_in ribosomal small subunit biogenesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
part_of Pwp2p-containing subcomplex of 90S preribosome	IBA Inferred from Biological aspect of Ancestor more info
located_in nuclear membrane	IEA Inferred from Electronic Annotation more info
located_in nuclear membrane	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	IEA Inferred from Electronic Annotation more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	IBA Inferred from Biological aspect of Ancestor more info
part_of small-subunit processome	ISO Inferred from Sequence Orthology more info
part_of small-subunit processome	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: U3 small nucleolar RNA-associated protein 18 homolog

Names: UTP18, small subunit (SSU) processome component, homolog; WD repeat domain 50; WD repeat-containing protein 50

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001013375.1 → NP_001013393.1 U3 small nucleolar RNA-associated protein 18 homolog

See identical proteins and their annotated locations for NP_001013393.1

Status: VALIDATED

Source sequence(s)

AK032265, AK078033, BC119622, BG067111, BY743008

Consensus CDS

CCDS25245.1

UniProtKB/Swiss-Prot

Q5SSI6

UniProtKB/TrEMBL

Q3U3Q3

Related

ENSMUSP00000068103.4, ENSMUST00000066888.10

Conserved Domains (3) summary

COG2319
Location:217 → 547

WD40; WD40 repeat [General function prediction only]

sd00039
Location:250 → 290

7WD40; WD40 repeat [structural motif]

cl02567
Location:250 → 488

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...