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    Arhgef2 Rho/Rac guanine nucleotide exchange factor 2 [ Mus musculus (house mouse) ]

    Gene ID: 16800, updated on 3-Dec-2024

    Summary

    Official Symbol
    Arhgef2provided by MGI
    Official Full Name
    Rho/Rac guanine nucleotide exchange factor 2provided by MGI
    Primary source
    MGI:MGI:103264
    See related
    Ensembl:ENSMUSG00000028059 AllianceGenome:MGI:103264
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    GEF; Lfc; P40; GEFH1; LFP40; Lbcl1; GEF-H1; mKIAA0651
    Summary
    Enables guanyl-nucleotide exchange factor activity and microtubule binding activity. Involved in several processes, including asymmetric neuroblast division; establishment of mitotic spindle orientation; and positive regulation of neuron migration. Acts upstream of or within several processes, including actin filament organization; negative regulation of podosome assembly; and regulation of Rho protein signal transduction. Located in several cellular components, including dendritic shaft; podosome; and postsynaptic density. Is expressed in several structures, including brain; dorsal root ganglion; liver; and testis. Used to study neurodevelopmental disorder with midbrain and hindbrain malformations. Human ortholog(s) of this gene implicated in neurodevelopmental disorder with midbrain and hindbrain malformations. Orthologous to human ARHGEF2 (Rho/Rac guanine nucleotide exchange factor 2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 23.5), lung adult (RPKM 11.9) and 27 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Arhgef2 in Genome Data Viewer
    Location:
    3 F1; 3 38.9 cM
    Exon count:
    35
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (88500427..88556839)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (88593105..88649532)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E6069 Neighboring gene STARR-seq mESC enhancer starr_08203 Neighboring gene STARR-seq mESC enhancer starr_08204 Neighboring gene STARR-positive B cell enhancer ABC_E9078 Neighboring gene STARR-positive B cell enhancer ABC_E6070 Neighboring gene signal sequence receptor, beta Neighboring gene predicted gene, 52660 Neighboring gene STARR-positive B cell enhancer ABC_E1622 Neighboring gene predicted gene, 40090 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88425928-88426111 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88426160-88426313 Neighboring gene predicted gene 20652 Neighboring gene STARR-seq mESC enhancer starr_08213 Neighboring gene STARR-seq mESC enhancer starr_08214 Neighboring gene relaxin family peptide receptor 4 Neighboring gene STARR-positive B cell enhancer ABC_E2077 Neighboring gene CapStarr-seq enhancer MGSCv37_chr3:88490214-88490323 Neighboring gene KH domain containing 4, pre-mRNA splicing factor Neighboring gene predicted gene, 25820

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables guanyl-nucleotide exchange factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables guanyl-nucleotide exchange factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables microtubule binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables small GTPase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in actin filament organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within actin filament organization IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in actin filament organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in actin filament organization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in asymmetric neuroblast division IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in asymmetric neuroblast division ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within cell morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell morphogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cell morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to muramyl dipeptide ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in cellular response to muramyl dipeptide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in establishment of mitotic spindle orientation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in innate immune response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of microtubule depolymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of microtubule depolymerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of neurogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of NF-kappaB transcription factor activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of NF-kappaB transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-6 production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of interleukin-6 production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of neuron differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of neuron differentiation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of neuron migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of peptidyl-tyrosine phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of Rho protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within regulation of Rho protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in bicellular tight junction IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoskeleton ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytoskeleton ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendritic shaft IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal cell body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynaptic density, intracellular component ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in ruffle membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in ruffle membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in ruffle membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    rho guanine nucleotide exchange factor 2
    Names
    LBC'S first cousin
    guanine nucleotide exchange factor H1
    lymphoid blast crisis-like 1
    oncogene LFC
    rho/rac guanine nucleotide exchange factor (GEF) 2
    rhobin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001198911.2NP_001185840.1  rho guanine nucleotide exchange factor 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) has multiple differences at its 5' end, including a different translation initiation site, compared to variant 1. Variant 2 encodes a shorter protein (isoform 2) with a different N-terminus, compared to isoform 1.
      Source sequence(s)
      AC145168
      Consensus CDS
      CCDS57220.1
      UniProtKB/TrEMBL
      H3BJ45, H3BJU7
      Related
      ENSMUSP00000134840.2, ENSMUST00000177498.8
      Conserved Domains (4) summary
      cd00029
      Location:2570
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:220414
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:454569
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:457555
      PH; PH domain
    2. NM_001198912.2NP_001185841.1  rho guanine nucleotide exchange factor 2 isoform 3

      See identical proteins and their annotated locations for NP_001185841.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) has a different 5' UTR and uses a downstream in-frame translation initiation site, compared to variant 1. Variant 3 encodes a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AC145168
      Consensus CDS
      CCDS57222.1
      UniProtKB/TrEMBL
      H3BJU7
      Related
      ENSMUSP00000103134.4, ENSMUST00000107510.10
      Conserved Domains (4) summary
      cd00029
      Location:1358
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:210404
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:773845
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:444559
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    3. NM_001198913.2NP_001185842.1  rho guanine nucleotide exchange factor 2 isoform 4

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) has multiple differences at its 5' end and uses a downstream in-frame translation initiation site, compared to variant 1. Variant 4 encodes a shorter protein (isoform 4), compared to isoform 1.
      Source sequence(s)
      AC145168
      Consensus CDS
      CCDS57221.1
      UniProtKB/TrEMBL
      H3BJU7
      Related
      ENSMUSP00000127843.3, ENSMUST00000170653.9
      Conserved Domains (4) summary
      cd00029
      Location:1358
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:208402
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:771843
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:442557
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    4. NM_001377126.1NP_001364055.1  rho guanine nucleotide exchange factor 2 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC145168
      UniProtKB/TrEMBL
      H3BJU7
      Conserved Domains (3) summary
      cd00160
      Location:229423
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:463578
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cd20877
      Location:2787
      C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
    5. NM_001428493.1NP_001415422.1  rho guanine nucleotide exchange factor 2 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC145168
      UniProtKB/TrEMBL
      H3BJ40, H3BJU7
    6. NM_001428494.1NP_001415423.1  rho guanine nucleotide exchange factor 2 isoform 7

      Status: VALIDATED

      Source sequence(s)
      AC145168
      UniProtKB/TrEMBL
      H3BKH9
    7. NM_001428495.1NP_001415424.1  rho guanine nucleotide exchange factor 2 isoform 8

      Status: VALIDATED

      Source sequence(s)
      AC145168
      UniProtKB/TrEMBL
      H3BJU7
    8. NM_001428496.1NP_001415425.1  rho guanine nucleotide exchange factor 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC145168
      UniProtKB/TrEMBL
      H3BJU7
    9. NM_001428497.1NP_001415426.1  rho guanine nucleotide exchange factor 2 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC145168
      UniProtKB/TrEMBL
      H3BJU7
    10. NM_008487.4NP_032513.3  rho guanine nucleotide exchange factor 2 isoform 1

      See identical proteins and their annotated locations for NP_032513.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC145168
      Consensus CDS
      CCDS17481.1
      UniProtKB/Swiss-Prot
      E9QNW9, O09115, Q3TBI4, Q3TJ16, Q60875, Q8CHE1, Q923E0, Q9ESG7
      UniProtKB/TrEMBL
      H3BKH9
      Related
      ENSMUSP00000029694.8, ENSMUST00000029694.14
      Conserved Domains (4) summary
      cd00029
      Location:4085
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:237431
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:471586
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      pfam00169
      Location:474572
      PH; PH domain

    RNA

    1. NR_190380.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC145168

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      88500427..88556839
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011240027.4XP_011238329.1  rho guanine nucleotide exchange factor 2 isoform X4

      UniProtKB/TrEMBL
      H3BJX8
      Conserved Domains (4) summary
      cd00029
      Location:240285
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:437631
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:10001072
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:671786
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    2. XM_006501058.4XP_006501121.1  rho guanine nucleotide exchange factor 2 isoform X1

      UniProtKB/TrEMBL
      H3BJX8
      Related
      ENSMUSP00000135168.3, ENSMUST00000175903.9
      Conserved Domains (4) summary
      cd00029
      Location:240285
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:437631
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:10001072
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:671786
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    3. XM_006501059.4XP_006501122.1  rho guanine nucleotide exchange factor 2 isoform X2

      UniProtKB/TrEMBL
      H3BJX8
      Conserved Domains (4) summary
      cd00029
      Location:240285
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:435629
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:9981070
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:669784
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    4. XM_006501060.4XP_006501123.1  rho guanine nucleotide exchange factor 2 isoform X3

      UniProtKB/TrEMBL
      H3BJX8
      Conserved Domains (4) summary
      cd00029
      Location:173218
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:370564
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:9331005
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:604719
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    5. XM_006501066.2XP_006501129.1  rho guanine nucleotide exchange factor 2 isoform X8

      Related
      ENSMUSP00000134834.2, ENSMUST00000176500.8
      Conserved Domains (4) summary
      cd00029
      Location:2570
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:222416
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:785857
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:456571
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    6. XM_030252438.2XP_030108298.1  rho guanine nucleotide exchange factor 2 isoform X6

      Conserved Domains (4) summary
      cd00029
      Location:4085
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:235429
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:798870
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:469584
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    7. XM_006501067.5XP_006501130.1  rho guanine nucleotide exchange factor 2 isoform X9

      Conserved Domains (4) summary
      cd00029
      Location:1358
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:210404
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:773845
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:444559
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    8. XM_030252439.2XP_030108299.1  rho guanine nucleotide exchange factor 2 isoform X10

      Conserved Domains (4) summary
      cd00029
      Location:1358
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:208402
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:771843
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:442557
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    9. XM_036162907.1XP_036018800.1  rho guanine nucleotide exchange factor 2 isoform X5

      UniProtKB/TrEMBL
      H3BJU7
      Conserved Domains (3) summary
      cd00160
      Location:239433
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:473588
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
      cd20877
      Location:3797
      C1_ARHGEF2; protein kinase C conserved region 1 (C1 domain) found in Rho guanine nucleotide exchange factor 2 (ARHGEF2) and similar proteins
    10. XM_036162908.1XP_036018801.1  rho guanine nucleotide exchange factor 2 isoform X11

      Conserved Domains (2) summary
      cd00160
      Location:58252
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:292407
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    11. XM_006501065.4XP_006501128.1  rho guanine nucleotide exchange factor 2 isoform X7

      Conserved Domains (4) summary
      cd00029
      Location:3277
      C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
      cd00160
      Location:227421
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      TIGR02680
      Location:790862
      TIGR02680; TIGR02680 family protein
      cd13393
      Location:461576
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain
    12. XM_036162909.1XP_036018802.1  rho guanine nucleotide exchange factor 2 isoform X11

      UniProtKB/TrEMBL
      H3BJU7
      Conserved Domains (2) summary
      cd00160
      Location:58252
      RhoGEF; Guanine nucleotide exchange factor for Rho/Rac/Cdc42-like GTPases; Also called Dbl-homologous (DH) domain. It appears that PH domains invariably occur C-terminal to RhoGEF/DH domains.
      cd13393
      Location:292407
      PH_ARHGEF2; Rho guanine nucleotide exchange factor 2 Pleckstrin homology (PH) domain