Bmi1 Bmi1 polycomb ring finger oncogene [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Bmi1provided by MGI
Official Full Name: Bmi1 polycomb ring finger oncogeneprovided by MGI
Primary source: MGI:MGI:88174
See related: Ensembl:ENSMUSG00000026739 AllianceGenome:MGI:88174
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Bmi-1; Pcgf4
Summary: Enables promoter-specific chromatin binding activity and ubiquitin-protein transferase activator activity. Involved in positive regulation of B cell proliferation and positive regulation of immature T cell proliferation in thymus. Acts upstream of or within several processes, including chordate embryonic development; negative regulation of macromolecule biosynthetic process; and regulation of adaxial/abaxial pattern formation. Located in heterochromatin and nuclear body. Part of PRC1 complex. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in acute myeloid leukemia; colorectal carcinoma; hepatocellular carcinoma; and renal Wilms' tumor. Orthologous to human BMI1 (BMI1 proto-oncogene, polycomb ring finger) and COMMD3-BMI1 (COMMD3-BMI1 readthrough). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in whole brain E14.5 (RPKM 11.2), testis adult (RPKM 11.2) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 2 A3; 2 12.9 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	2	NC_000068.8 (18681953..18691440)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	2	NC_000068.7 (18677018..18686629)

Chromosome 2 - NC_000068.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting Metastasis in Colorectal Cancer.
Title: Targeting Bmi1 for Enhancing Anoikis Sensitivity and Inhibiting Metastasis in Colorectal Cancer.
CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway.
Title: CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway.
The transcription factor BMI1 increases hypoxic signaling in oral cavity epithelia.
Title: The transcription factor BMI1 increases hypoxic signaling in oral cavity epithelia.
Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFbeta1-Induced Epithelial-Mesenchymal Transition.
Title: Chk2 Modulates Bmi1-Deficiency-Induced Renal Aging and Fibrosis via Oxidative Stress, DNA Damage, and p53/TGFβ1-Induced Epithelial-Mesenchymal Transition.
Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
Title: Peptidase inhibitor 16 promotes inflammatory arthritis by suppressing Foxp3 expression via regulating K48-linked ubiquitin degradation Bmi-1 in regulatory T cells.
BMI1-induced CD127+KLRG1+ memory T cells enhance the efficacy of liver cancer immunotherapy.
Title: BMI1-induced CD127+KLRG1+ memory T cells enhance the efficacy of liver cancer immunotherapy.
BMI1 is required for melanocyte stem cell maintenance and hair pigmentation.
Title: BMI1 is required for melanocyte stem cell maintenance and hair pigmentation.
Nuclear translocation of YAP drives BMI-associated hepatocarcinogenesis in hepatitis B virus infection.
Title: Nuclear translocation of YAP drives BMI-associated hepatocarcinogenesis in hepatitis B virus infection.
BMI-1 activates hepatic stellate cells to promote the epithelial-mesenchymal transition of colorectal cancer cells.
Title: BMI-1 activates hepatic stellate cells to promote the epithelial-mesenchymal transition of colorectal cancer cells.
Therapeutic inhibition of Bmi-1 ablates chemoresistant cancer stem cells in adenoid cystic carcinoma.
Title: Therapeutic inhibition of Bmi-1 ablates chemoresistant cancer stem cells in adenoid cystic carcinoma.

Submit: New GeneRIF Correction See all GeneRIFs (182)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (5)
Targeted (11) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

M64279 (e-PCR)
- UniSTS:124972

MARC_15439-15451:1010170069:5 (e-PCR)
- UniSTS:267836

NoName (e-PCR)
- UniSTS:234331

Bmi1 (e-PCR), detects polymorphism
- UniSTS:515958

AW550818 (e-PCR)
- UniSTS:178578

AW546694 (e-PCR)
- UniSTS:178579

AU022527 (e-PCR)
- UniSTS:167331

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RING-like zinc finger domain binding	IEA Inferred from Electronic Annotation more info
enables RING-like zinc finger domain binding	ISO Inferred from Sequence Orthology more info
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables promoter-specific chromatin binding	IBA Inferred from Biological aspect of Ancestor more info
enables promoter-specific chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables promoter-specific chromatin binding	ISO Inferred from Sequence Orthology more info
enables promoter-specific chromatin binding	ISS Inferred from Sequence or Structural Similarity more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables ubiquitin-protein transferase activator activity	IDA Inferred from Direct Assay more info	PubMed
enables zinc ion binding	ISO Inferred from Sequence Orthology more info
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA methylation-dependent constitutive heterochromatin formation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within brain development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in cellular response to dexamethasone stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to interleukin-1	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within chromatin organization	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within chromatin organization	IGI Inferred from Genetic Interaction more info	PubMed
involved_in chromatin remodeling	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within embryonic skeletal system development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within embryonic skeletal system morphogenesis	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within hematopoietic stem cell homeostasis	ISO Inferred from Sequence Orthology more info
involved_in hemopoiesis	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within humoral immune response	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within in utero embryonic development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of apoptotic signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of gene expression, epigenetic	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of transcription by RNA polymerase II	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within negative regulation of transcription by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of B cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of immature T cell proliferation in thymus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of ubiquitin-protein transferase activity	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within regulation of adaxial/abaxial pattern formation	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of kidney development	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within rostrocaudal neural tube patterning	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within skeletal system development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within somatic stem cell division	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PRC1 complex	IBA Inferred from Biological aspect of Ancestor more info
part_of PRC1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of PRC1 complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	IDA Inferred from Direct Assay more info	PubMed
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	IDA Inferred from Direct Assay more info	PubMed
located_in nuclear body	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info	PubMed
part_of ubiquitin ligase complex	ISO Inferred from Sequence Orthology more info
part_of ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: polycomb complex protein BMI-1

Names: B lymphoma Mo-MLV insertion region 1; polycomb group RING finger protein 4; polycomb group ring finger 4

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001416911.1 → NP_001403840.1 polycomb complex protein BMI-1

Status: VALIDATED

Source sequence(s)

AL928680

UniProtKB/Swiss-Prot

P25916

UniProtKB/TrEMBL

Q2LC58
NM_001416912.1 → NP_001403841.1 polycomb complex protein BMI-1

Status: VALIDATED

Source sequence(s)

AL928680

UniProtKB/Swiss-Prot

P25916

UniProtKB/TrEMBL

Q2LC58

Related

ENSMUSP00000110300.2, ENSMUST00000051929.13
NM_001416913.1 → NP_001403842.1 polycomb complex protein BMI-1

Status: VALIDATED

Source sequence(s)

AL928680

UniProtKB/Swiss-Prot

P25916

UniProtKB/TrEMBL

Q2LC58
NM_001416914.1 → NP_001403843.1 polycomb complex protein BMI-1

Status: VALIDATED

Source sequence(s)

AL928680

UniProtKB/Swiss-Prot

P25916

UniProtKB/TrEMBL

Q2LC58
NM_007552.5 → NP_031578.2 polycomb complex protein BMI-1

See identical proteins and their annotated locations for NP_031578.2

Status: VALIDATED

Source sequence(s)

AL928680

Consensus CDS

CCDS15711.1

UniProtKB/Swiss-Prot

P25916

UniProtKB/TrEMBL

Q2LC58, Q3ULL2

Related

ENSMUSP00000028071.7, ENSMUST00000028071.13

Conserved Domains (3) summary

TIGR00599
Location:8 → 132

rad18; DNA repair protein rad18

cd16736
Location:12 → 65

RING-HC_PCGF4; RING finger found in polycomb group RING finger protein 4 (PCGF4) and similar proteins

cd17165
Location:130 → 224

RAWUL_PCGF4; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in polycomb group RING finger protein 4 (PCGF4)