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    Dtx4 deltex 4, E3 ubiquitin ligase [ Mus musculus (house mouse) ]

    Gene ID: 207521, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dtx4provided by MGI
    Official Full Name
    deltex 4, E3 ubiquitin ligaseprovided by MGI
    Primary source
    MGI:MGI:2672905
    See related
    Ensembl:ENSMUSG00000039982 AllianceGenome:MGI:2672905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RNF155; D930042H13
    Summary
    Predicted to enable ubiquitin protein ligase activity. Predicted to be involved in several processes, including Notch signaling pathway; proteasome-mediated ubiquitin-dependent protein catabolic process; and protein K48-linked ubiquitination. Predicted to be located in cytoplasm. Predicted to be active in centrosome and nucleoplasm. Is expressed in several structures, including central nervous system; genitourinary system; and retina. Orthologous to human DTX4 (deltex E3 ubiquitin ligase 4). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 16.0), CNS E11.5 (RPKM 13.0) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dtx4 in Genome Data Viewer
    Location:
    19 A; 19 8.72 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (12443700..12479509, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (12466329..12502179, complement)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene pore forming protein-like Neighboring gene macrophage expressed gene 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:12551432-12551640 Neighboring gene STARR-positive B cell enhancer ABC_E2522 Neighboring gene STARR-seq mESC enhancer starr_45593 Neighboring gene predicted gene, 57827 Neighboring gene family with sequence similarity 111, member A pseudogene Neighboring gene STARR-positive B cell enhancer mm9_chr19:12615291-12615592 Neighboring gene STARR-seq mESC enhancer starr_45594 Neighboring gene STARR-seq mESC enhancer starr_45595 Neighboring gene family with sequence similarity 111, member A pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. E3 ubiquitin ligase DTX4 is required for adipogenic differentiation in 3T3-L1 preadipocytes cell line. Wang Z, et al. Biochem Biophys Res Commun, 2017 Oct 21. PMID 28842252
    2. Normal immune system development in mice lacking the Deltex-1 RING finger domain. Storck S, et al. Mol Cell Biol, 2005 Feb. PMID 15684394, Free PMC Article
    3. T cells develop normally in the absence of both Deltex1 and Deltex2. Lehar SM, et al. Mol Cell Biol, 2006 Oct. PMID 16923970, Free PMC Article
    4. Identification of molecules preferentially expressed beneath the marginal zone in the developing cerebral cortex. Tachikawa K, et al. Neurosci Res, 2008 Feb. PMID 18055048
    5. Analogous mechanism regulating formation of neocortical basal radial glia and cerebellar Bergmann glia. Heng X, et al. Elife, 2017 May 10. PMID 28489004, Free PMC Article

    See all (25) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (2) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin protein ligase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in Notch signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in Notch signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of innate immune response IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of innate immune response ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasomal protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein K48-linked ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein K48-linked ubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein ubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in centrosome IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in centrosome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in nucleoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    E3 ubiquitin-protein ligase DTX4
    Names
    RING-type E3 ubiquitin transferase DTX4
    deltex 4 homolog
    deltex4
    protein deltex-4
    NP_001388321.1
    NP_766030.3

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001401392.1 → NP_001388321.1  E3 ubiquitin-protein ligase DTX4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC151730

    2. NM_172442.3 → NP_766030.3  E3 ubiquitin-protein ligase DTX4 isoform 1

      See identical proteins and their annotated locations for NP_766030.3

      Status: VALIDATED

      Source sequence(s)
      BC058647, BU705490, CA328050, CF537541, CN525673
      Consensus CDS
      CCDS29631.1
      UniProtKB/Swiss-Prot
      Q6IS30, Q6PDK8, Q8BID3
      Related
      ENSMUSP00000040229.8, ENSMUST00000045521.9
      Conserved Domains (4) summary
      smart00678
      Location:8 → 86
      WWE; Domain in Deltex and TRIP12 homologues. Possibly involved in regulation of ubiquitin-mediated proteolysis
      cd09633
      Location:473 → 605
      Deltex_C; Domain found at the C-terminus of deltex-like
      cd00162
      Location:405 → 466
      RING; RING-finger (Really Interesting New Gene) domain, a specialized type of Zn-finger of 40 to 60 residues that binds two atoms of zinc; defined by the 'cross-brace' motif C-X2-C-X(9-39)-C-X(1-3)- H-X(2-3)-(N/C/H)-X2-C-X(4-48)C-X2-C; probably involved in ...
      pfam02825
      Location:90 → 144
      WWE; WWE domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      12443700..12479509 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q6PDK8.2 GenPept UniProtKB/Swiss-Prot:Q6PDK8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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