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    Hs3st5 heparan sulfate (glucosamine) 3-O-sulfotransferase 5 [ Mus musculus (house mouse) ]

    Gene ID: 319415, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Hs3st5provided by MGI
    Official Full Name
    heparan sulfate (glucosamine) 3-O-sulfotransferase 5provided by MGI
    Primary source
    MGI:MGI:2441996
    See related
    Ensembl:ENSMUSG00000044499 AllianceGenome:MGI:2441996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Gm1151; Hs3ost5; D930005L05Rik
    Summary
    Predicted to enable [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity. Predicted to be involved in several processes, including heparan sulfate proteoglycan biosynthetic process, enzymatic modification; protein sulfation; and regulation of viral entry into host cell. Predicted to be located in Golgi membrane. Is expressed in cortical plate and main olfactory bulb. Orthologous to human HS3ST5 (heparan sulfate-glucosamine 3-sulfotransferase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in CNS E18 (RPKM 3.3), whole brain E14.5 (RPKM 2.4) and 7 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Hs3st5 in Genome Data Viewer
    Location:
    10 B1; 10 19.31 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (36382794..36710393)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (36506590..36834397)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_26309 Neighboring gene STARR-seq mESC enhancer starr_26310 Neighboring gene STARR-seq mESC enhancer starr_26311 Neighboring gene STARR-seq mESC enhancer starr_26312 Neighboring gene STARR-seq mESC enhancer starr_26313 Neighboring gene STARR-seq mESC enhancer starr_26314 Neighboring gene STARR-seq mESC enhancer starr_26315 Neighboring gene S-adenosylmethionine decarboxylase 2 Neighboring gene STARR-seq mESC enhancer starr_26316 Neighboring gene predicted gene, 40623 Neighboring gene STARR-seq mESC enhancer starr_26317 Neighboring gene STARR-seq mESC enhancer starr_26318 Neighboring gene STARR-seq mESC enhancer starr_26319 Neighboring gene STARR-seq mESC enhancer starr_26320 Neighboring gene STARR-seq mESC enhancer starr_26322 Neighboring gene STARR-seq mESC enhancer starr_26323 Neighboring gene STARR-seq mESC enhancer starr_26324 Neighboring gene STARR-seq mESC enhancer starr_26325 Neighboring gene VISTA enhancer mm693 Neighboring gene STARR-seq mESC enhancer starr_26326 Neighboring gene STARR-seq mESC enhancer starr_26327 Neighboring gene STARR-seq mESC enhancer starr_26330 Neighboring gene STARR-seq mESC enhancer starr_26331 Neighboring gene predicted gene, 22554 Neighboring gene STARR-seq mESC enhancer starr_26332 Neighboring gene STARR-seq mESC enhancer starr_26333 Neighboring gene STARR-seq mESC enhancer starr_26336 Neighboring gene STARR-positive B cell enhancer mm9_chr10:36693912-36694212 Neighboring gene STARR-seq mESC enhancer starr_26337 Neighboring gene STARR-seq mESC enhancer starr_26339 Neighboring gene STARR-seq mESC enhancer starr_26341 Neighboring gene STARR-seq mESC enhancer starr_26343 Neighboring gene STARR-seq mESC enhancer starr_26344 Neighboring gene STARR-positive B cell enhancer ABC_E6829 Neighboring gene histone deacetylase 2 Neighboring gene myristoylated alanine rich protein kinase C substrate

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Biosynthesis of 3-O-sulfated heparan sulfate: unique substrate specificity of heparan sulfate 3-O-sulfotransferase isoform 5. Chen J, et al. Glycobiology, 2003 Nov. PMID 12907690
    2. Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Patel VN, et al. Nat Commun, 2024 Aug 31. PMID 39217171, Free PMC Article
    3. Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Bedogni F, et al. Front Mol Neurosci, 2021. PMID 34321999, Free PMC Article
    4. GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Visel A, et al. Nucleic Acids Res, 2004 Jan 1. PMID 14681479, Free PMC Article
    5. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables [heparan sulfate]-glucosamine 3-sulfotransferase 1 activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Process Evidence Code Pubs
    involved_in heparan sulfate proteoglycan biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in heparan sulfate proteoglycan biosynthetic process, enzymatic modification ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in negative regulation of coagulation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of coagulation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein sulfation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of viral entry into host cell ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of viral entry into host cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  

    General protein information

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    Preferred Names
    heparan sulfate glucosamine 3-O-sulfotransferase 5
    Names
    heparan sulfate D-glucosaminyl 3-O-sulfotransferase 5
    NP_001074677.1
    NP_001240284.1
    NP_001240285.1
    XP_006512824.1
    XP_030100975.1
    XP_036011701.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001081208.2 → NP_001074677.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      See identical proteins and their annotated locations for NP_001074677.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) lacks two exons in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC079867, CJ113442
      Consensus CDS
      CCDS35881.1
      UniProtKB/Swiss-Prot
      Q8BSL4
      UniProtKB/TrEMBL
      B2RXW6
      Related
      ENSMUSP00000129434.2, ENSMUST00000168572.8
      Conserved Domains (1) summary
      pfam00685
      Location:90 → 330
      Sulfotransfer_1; Sulfotransferase domain

    2. NM_001253355.1 → NP_001240284.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      See identical proteins and their annotated locations for NP_001240284.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      AK031910, BC079867, CJ113442
      Consensus CDS
      CCDS35881.1
      UniProtKB/Swiss-Prot
      Q8BSL4
      UniProtKB/TrEMBL
      B2RXW6
      Related
      ENSMUSP00000060229.5, ENSMUST00000058738.11
      Conserved Domains (1) summary
      pfam00685
      Location:90 → 330
      Sulfotransfer_1; Sulfotransferase domain

    3. NM_001253356.1 → NP_001240285.1  heparan sulfate glucosamine 3-O-sulfotransferase 5

      See identical proteins and their annotated locations for NP_001240285.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an exon in the 5' UTR compared to variant 1. Variants 1, 2 and 3 encode the same protein.
      Source sequence(s)
      BC079867, BC147493, CJ113442
      Consensus CDS
      CCDS35881.1
      UniProtKB/Swiss-Prot
      Q8BSL4
      UniProtKB/TrEMBL
      B2RXW6
      Related
      ENSMUSP00000130778.2, ENSMUST00000167191.8
      Conserved Domains (1) summary
      pfam00685
      Location:90 → 330
      Sulfotransfer_1; Sulfotransferase domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      36382794..36710393
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006512761.4 → XP_006512824.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

      See identical proteins and their annotated locations for XP_006512824.1

      UniProtKB/Swiss-Prot
      Q8BSL4
      UniProtKB/TrEMBL
      B2RXW6
      Conserved Domains (1) summary
      pfam00685
      Location:90 → 330
      Sulfotransfer_1; Sulfotransferase domain

    2. XM_030245115.2 → XP_030100975.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

      UniProtKB/Swiss-Prot
      Q8BSL4
      UniProtKB/TrEMBL
      B2RXW6
      Conserved Domains (1) summary
      pfam00685
      Location:90 → 330
      Sulfotransfer_1; Sulfotransferase domain

    3. XM_036155808.1 → XP_036011701.1  heparan sulfate glucosamine 3-O-sulfotransferase 5 isoform X1

      UniProtKB/Swiss-Prot
      Q8BSL4
      UniProtKB/TrEMBL
      B2RXW6
      Conserved Domains (1) summary
      pfam00685
      Location:90 → 330
      Sulfotransfer_1; Sulfotransferase domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BSL4.1 GenPept UniProtKB/Swiss-Prot:Q8BSL4

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