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    Saa1 serum amyloid A 1 [ Mus musculus (house mouse) ]

    Gene ID: 20208, updated on 3-Dec-2024

    Summary

    Official Symbol
    Saa1provided by MGI
    Official Full Name
    serum amyloid A 1provided by MGI
    Primary source
    MGI:MGI:98221
    See related
    Ensembl:ENSMUSG00000074115 AllianceGenome:MGI:98221
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Saa2; Saa-1
    Summary
    Predicted to enable G protein-coupled receptor binding activity. Acts upstream of or within cholesterol metabolic process and response to bacterium. Located in extracellular space. Is expressed in extraembryonic component; intestine; liver; and placenta. Orthologous to human SAA1 (serum amyloid A1) and SAA2 (serum amyloid A2). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in colon adult (RPKM 137.3), large intestine adult (RPKM 79.1) and 1 other tissue See more
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    Genomic context

    See Saa1 in Genome Data Viewer
    Location:
    7 B3; 7 30.54 cM
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (46389921..46392404, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (46740497..46743181, complement)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene serum amyloid A 4 Neighboring gene serum amyloid A, pseudogene Neighboring gene STARR-seq mESC enhancer starr_18868 Neighboring gene serum amyloid A 2 Neighboring gene HPS5, biogenesis of lysosomal organelles complex 2 subunit 2 Neighboring gene STARR-seq mESC enhancer starr_18870 Neighboring gene STARR-positive B cell enhancer ABC_E6548

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (1)  1 citation

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables G protein-coupled receptor binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables heparin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in acute-phase response IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within cholesterol metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasmic microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of high-density lipoprotein particle IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    serum amyloid A-1 protein
    Names
    serum amyloid A 2

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001357493.1NP_001344422.1  serum amyloid A-1 protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC090122
      Consensus CDS
      CCDS21284.1
      UniProtKB/Swiss-Prot
      P05366
      UniProtKB/TrEMBL
      Q5I0U6, Q64454, Q8R3T4
      Conserved Domains (1) summary
      pfam00277
      Location:23122
      SAA; Serum amyloid A protein
    2. NM_001403085.1NP_001390014.1  serum amyloid A-1 protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC090122
      UniProtKB/Swiss-Prot
      P05366
      UniProtKB/TrEMBL
      Q5I0U6, Q64454, Q8R3T4
    3. NM_001403086.1NP_001390015.1  serum amyloid A-1 protein precursor

      Status: VALIDATED

      Source sequence(s)
      AC090122
      UniProtKB/Swiss-Prot
      P05366
      UniProtKB/TrEMBL
      Q5I0U6, Q64454, Q8R3T4
    4. NM_009117.4NP_033143.1  serum amyloid A-1 protein precursor

      See identical proteins and their annotated locations for NP_033143.1

      Status: VALIDATED

      Source sequence(s)
      AC090122
      Consensus CDS
      CCDS21284.1
      UniProtKB/Swiss-Prot
      P05366
      UniProtKB/TrEMBL
      Q5I0U6, Q64454, Q8R3T4
      Related
      ENSMUSP00000119150.2, ENSMUST00000128088.4
      Conserved Domains (1) summary
      pfam00277
      Location:23122
      SAA; Serum amyloid A protein

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      46389921..46392404 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)