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    Prune1 prune exopolyphosphatase [ Mus musculus (house mouse) ]

    Gene ID: 229589, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Prune1provided by MGI
    Official Full Name
    prune exopolyphosphataseprovided by MGI
    Primary source
    MGI:MGI:1925152
    See related
    Ensembl:ENSMUSG00000015711 AllianceGenome:MGI:1925152
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Prune; HTCD37; DRES-17; PRUNEM1; Prune-M1; C130058A12; 9230112O05Rik
    Summary
    Predicted to enable exopolyphosphatase activity; phosphatase activity; and tubulin binding activity. Predicted to be involved in regulation of microtubule polymerization and regulation of neurogenesis. Predicted to be located in cytosol. Predicted to be active in cytoplasm. Is expressed in several structures, including exocrine gland; eye; genitourinary system; gut; and nervous system. Orthologous to human PRUNE1 (prune exopolyphosphatase 1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E18 (RPKM 23.6), whole brain E14.5 (RPKM 20.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Prune1 in Genome Data Viewer
    Location:
    3 F2.1; 3 40.74 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 3 NC_000069.7 (95160985..95190817, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 3 NC_000069.6 (95253674..95283506, complement)

    Chromosome 3 - NC_000069.7Genomic Context describing neighboring genes Neighboring gene myeloid/lymphoid or mixed-lineage leukemia; translocated to, 11 Neighboring gene CDC42 small effector 1 Neighboring gene predicted gene 128 Neighboring gene BCL2/adenovirus E1B 19kD interacting protein like Neighboring gene STARR-positive B cell enhancer ABC_E2672 Neighboring gene MINDY lysine 48 deubiquitinase 1 Neighboring gene annexin A9 Neighboring gene STARR-positive B cell enhancer ABC_E9560 Neighboring gene predicted gene, 53243 Neighboring gene ceramide synthase 2 Neighboring gene SET domain, bifurcated 1 Neighboring gene STARR-seq mESC enhancer starr_08380 Neighboring gene predicted gene, 37500

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction. Carotenuto M, et al. Naunyn Schmiedebergs Arch Pharmacol, 2015 Feb. PMID 25138575
    2. Amplification and overexpression of PRUNE in human sarcomas and breast carcinomas-a possible mechanism for altering the nm23-H1 activity. Forus A, et al. Oncogene, 2001 Oct 18. PMID 11687967
    3. NMIHBA results from hypomorphic PRUNE1 variants that lack short-chain exopolyphosphatase activity. Nistala H, et al. Hum Mol Genet, 2021 Jan 6. PMID 33105479, Free PMC Article
    4. Generation of Conditional Knockout Alleles for PRUNE-1. Wu X, et al. Cells, 2023 Feb 6. PMID 36831191, Free PMC Article
    5. PRUNE and NM23-M1 expression in embryonic and adult mouse brain. Carotenuto P, et al. J Bioenerg Biomembr, 2006 Aug. PMID 17033939

    See all (35) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction
      Title: A therapeutic approach to treat prostate cancer by targeting Nm23-H1/h-Prune interaction.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 
    • Transgenic (1) 

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables exopolyphosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables inorganic diphosphate phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables phosphatase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables tubulin binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tubulin binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in regulation of microtubule polymerization IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of microtubule polymerization ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of neurogenesis IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of neurogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in focal adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    exopolyphosphatase PRUNE1
    Names
    protein prune homolog
    prune homolog
    NP_775482.1
    XP_030108440.1
    XP_036018950.1
    XP_036018951.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_173347.2 → NP_775482.1  exopolyphosphatase PRUNE1

      See identical proteins and their annotated locations for NP_775482.1

      Status: PROVISIONAL

      Source sequence(s)
      BC057546
      Consensus CDS
      CCDS17610.1
      UniProtKB/Swiss-Prot
      Q80VU0, Q8BIW1
      Related
      ENSMUSP00000015855.8, ENSMUST00000015855.8
      Conserved Domains (2) summary
      COG1227
      Location:21 → 286
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:218 → 357
      DHHA2; DHHA2 domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000069.7 Reference GRCm39 C57BL/6J

      Range
      95160985..95190817 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030252580.1 → XP_030108440.1  exopolyphosphatase PRUNE1 isoform X2

      Conserved Domains (2) summary
      COG1227
      Location:3 → 255
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:187 → 327
      DHHA2; DHHA2 domain

    2. XM_036163058.1 → XP_036018951.1  exopolyphosphatase PRUNE1 isoform X2

      Conserved Domains (2) summary
      COG1227
      Location:3 → 255
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:187 → 327
      DHHA2; DHHA2 domain

    3. XM_036163057.1 → XP_036018950.1  exopolyphosphatase PRUNE1 isoform X1

      Conserved Domains (2) summary
      COG1227
      Location:9 → 274
      PPX1; Inorganic pyrophosphatase/exopolyphosphatase [Energy production and conversion, Inorganic ion transport and metabolism]
      pfam02833
      Location:206 → 346
      DHHA2; DHHA2 domain
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8BIW1.1 GenPept UniProtKB/Swiss-Prot:Q8BIW1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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