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    Lsm14b LSM family member 14B [ Mus musculus (house mouse) ]

    Gene ID: 241846, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lsm14bprovided by MGI
    Official Full Name
    LSM family member 14Bprovided by MGI
    Primary source
    MGI:MGI:3040677
    See related
    Ensembl:ENSMUSG00000039108 AllianceGenome:MGI:3040677
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9430078B04
    Summary
    Enables RNA binding activity. Involved in several processes, including maternal mRNA clearance; meiotic cell cycle process involved in oocyte maturation; and ovarian follicle development. Located in cytoplasmic ribonucleoprotein granule. Is expressed in several structures, including early embryo; facial prominence; liver; oocyte; and spleen. Orthologous to human LSM14B (LSM family member 14B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E14 (RPKM 57.0), whole brain E14.5 (RPKM 50.6) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lsm14b in Genome Data Viewer
    Location:
    2 H4; 2 102.54 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (179666770..179677254)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (180024900..180035466)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene TATA-box binding protein associated factor 4 Neighboring gene RIKEN cDNA 4921531C22 gene Neighboring gene STARR-seq mESC enhancer starr_06725 Neighboring gene STARR-positive B cell enhancer ABC_E7896 Neighboring gene STARR-positive B cell enhancer ABC_E7897 Neighboring gene proteasome subunit alpha 7 Neighboring gene SS18, nBAF chromatin remodeling complex subunit like 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. LSM14B controls oocyte mRNA storage and stability to ensure female fertility. Shan LY, et al. Cell Mol Life Sci, 2023 Aug 14. PMID 37578641, Free PMC Article
    2. LSM14B coordinates protein component expression in the P-body and controls oocyte maturation. Zhang H, et al. J Genet Genomics, 2024 Jan. PMID 37481122
    3. LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice. Li H, et al. Adv Sci (Weinh), 2023 Jun. PMID 37083226, Free PMC Article
    4. Eif4enif1 haploinsufficiency disrupts oocyte mitochondrial dynamics and leads to subfertility. Ding Y, et al. Development, 2023 Dec 1. PMID 38088064
    5. Comparative analysis of vertebrates reveals that mouse primordial oocytes do not contain a Balbiani body. Dhandapani L, et al. J Cell Sci, 2022 Dec 1. PMID 34897463

    See all (26) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. LSM14B coordinates protein component expression in the P-body and controls oocyte maturation.
      Title: LSM14B coordinates protein component expression in the P-body and controls oocyte maturation.
    2. LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.
      Title: LSM14B is essential for oocyte meiotic maturation by regulating maternal mRNA storage and clearance.
    3. LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice.
      Title: LSM14B is an Oocyte-Specific RNA-Binding Protein Indispensable for Maternal mRNA Metabolism and Oocyte Development in Mice.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (2) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables mRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in maternal mRNA clearance IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle process involved in oocyte maturation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in membraneless organelle assembly IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in oogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in ovarian follicle development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of translation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of ribonucleoprotein complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein LSM14 homolog B
    Names
    LSM14 homolog B
    RNA-associated protein 55B
    mRAP55B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001372364.2 → NP_001359293.1  protein LSM14 homolog B isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL663067
      Conserved Domains (2) summary
      cd01736
      Location:6 → 79
      LSm14_N; Like-Sm protein 14, N-terminal domain
      pfam09532
      Location:287 → 388
      FDF; FDF domain

    2. NM_001411271.1 → NP_001398200.1  protein LSM14 homolog B isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL663067

    3. NM_001411272.1 → NP_001398201.1  protein LSM14 homolog B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL663067

    4. NM_001411273.1 → NP_001398202.1  protein LSM14 homolog B isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL663067

    5. NM_001411274.1 → NP_001398203.1  protein LSM14 homolog B isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL663067

    6. NM_001411275.1 → NP_001398204.1  protein LSM14 homolog B isoform 7

      Status: VALIDATED

      Source sequence(s)
      AL663067

    7. NM_001411276.1 → NP_001398205.1  protein LSM14 homolog B isoform 8

      Status: VALIDATED

      Source sequence(s)
      AL663067

    8. NM_001411277.1 → NP_001398206.1  protein LSM14 homolog B isoform 9

      Status: VALIDATED

      Source sequence(s)
      AL663067

    9. NM_001411278.1 → NP_001398207.1  protein LSM14 homolog B isoform 10

      Status: VALIDATED

      Source sequence(s)
      AL663067

    10. NM_001411279.1 → NP_001398208.1  protein LSM14 homolog B isoform 11

      Status: VALIDATED

      Source sequence(s)
      AL663067
      Related
      ENSMUSP00000062519.5, ENSMUST00000058764.6

    11. NM_177727.5 → NP_808395.2  protein LSM14 homolog B isoform 2

      See identical proteins and their annotated locations for NP_808395.2

      Status: VALIDATED

      Source sequence(s)
      AL663067
      Consensus CDS
      CCDS17165.2
      UniProtKB/Swiss-Prot
      A2AC71, Q8CGC4
      Related
      ENSMUSP00000055036.6, ENSMUST00000055485.12
      Conserved Domains (2) summary
      cd01736
      Location:6 → 79
      LSm14_N; Like-Sm protein 14, N-terminal domain
      pfam09532
      Location:248 → 349
      FDF; FDF domain

    RNA

    1. NR_177201.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL663067

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      179666770..179677254
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8CGC4.3 GenPept UniProtKB/Swiss-Prot:Q8CGC4

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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