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    Mslnl mesothelin-like [ Mus musculus (house mouse) ]

    Gene ID: 328783, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Mslnlprovided by MGI
    Official Full Name
    mesothelin-likeprovided by MGI
    Primary source
    MGI:MGI:3607710
    See related
    Ensembl:ENSMUSG00000041062 AllianceGenome:MGI:3607710
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    4732467B22
    Summary
    Predicted to be involved in cell-matrix adhesion. Predicted to be located in membrane. Predicted to be active in cell surface. Is expressed in brain; heart; lung; olfactory epithelium; and testis. Orthologous to human MSLNL (mesothelin like). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    human all
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    Genomic context

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    See Mslnl in Genome Data Viewer
    Location:
    17 A3.3; 17 12.84 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (25952477..25967328)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (25733503..25748354)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene guanine nucleotide binding protein (G protein), gamma 13 Neighboring gene CTF18, chromosome transmission fidelity factor 18 Neighboring gene STARR-positive B cell enhancer ABC_E3190 Neighboring gene RNA pseudouridylate synthase domain containing 1 Neighboring gene mesothelin Neighboring gene STARR-seq mESC enhancer starr_42110 Neighboring gene predicted gene, 41550

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    2. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    3. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell-matrix adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cell surface IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in membrane IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    mesothelin-like protein
    Names
    pre-pro-megakaryocyte-potentiating-factor-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_177822.3 → NP_808490.1  mesothelin-like protein precursor

      See identical proteins and their annotated locations for NP_808490.1

      Status: PROVISIONAL

      Source sequence(s)
      AC134908
      Consensus CDS
      CCDS28525.1
      UniProtKB/Swiss-Prot
      Q8C160
      Related
      ENSMUSP00000049020.6, ENSMUST00000047098.7
      Conserved Domains (1) summary
      pfam06060
      Location:58 → 584
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      25952477..25967328
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006524430.3 → XP_006524493.1  mesothelin-like protein isoform X2

      Conserved Domains (1) summary
      pfam06060
      Location:58 → 542
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

    2. XM_006524432.2 → XP_006524495.1  mesothelin-like protein isoform X3

      Conserved Domains (1) summary
      pfam06060
      Location:58 → 377
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)

    3. XM_006524428.4 → XP_006524491.1  mesothelin-like protein isoform X1

      See identical proteins and their annotated locations for XP_006524491.1

      UniProtKB/Swiss-Prot
      Q8C160
      Conserved Domains (1) summary
      pfam06060
      Location:58 → 584
      Mesothelin; Pre-pro-megakaryocyte potentiating factor precursor (Mesothelin)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8C160.1 GenPept UniProtKB/Swiss-Prot:Q8C160

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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