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    Rdh5 retinol dehydrogenase 5 [ Mus musculus (house mouse) ]

    Gene ID: 19682, updated on 3-Dec-2024

    Summary

    Official Symbol
    Rdh5provided by MGI
    Official Full Name
    retinol dehydrogenase 5provided by MGI
    Primary source
    MGI:MGI:1201412
    See related
    Ensembl:ENSMUSG00000025350 AllianceGenome:MGI:1201412
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    RDH4; cRDH; 9-cis
    Summary
    Enables all-trans-retinol dehydrogenase (NAD+) activity. Involved in retinoid metabolic process. Located in endoplasmic reticulum lumen. Is expressed in several structures, including aorta-gonad-mesonephros; central nervous system; embryo ectoderm; eye; and gut. Human ortholog(s) of this gene implicated in fundus albipunctatus and night blindness. Orthologous to human RDH5 (retinol dehydrogenase 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in liver adult (RPKM 27.1), duodenum adult (RPKM 13.1) and 26 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rdh5 in Genome Data Viewer
    Location:
    10 D3; 10 77.19 cM
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (128749457..128755906, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (128913588..128920037, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene growth differentiation factor 11 Neighboring gene STARR-positive B cell enhancer ABC_E2975 Neighboring gene CD63 antigen Neighboring gene STARR-positive B cell enhancer ABC_E6941 Neighboring gene biogenesis of lysosomal organelles complex-1, subunit 1 Neighboring gene integrin alpha 7 Neighboring gene predicted gene, 25494 Neighboring gene thiol methyltransferase 1B

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables 11-cis-retinol dehydrogenase IEA
    Inferred from Electronic Annotation
    more info
     
    enables all-trans-retinol dehydrogenase (NAD+) activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables all-trans-retinol dehydrogenase (NAD+) activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables all-trans-retinol dehydrogenase (NAD+) activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables androstan-3-alpha,17-beta-diol dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables androsterone dehydrogenase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables androsterone dehydrogenase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein homodimerization activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein homodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in retinoid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in retinoid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in retinoid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in retinol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in steroid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in steroid metabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in steroid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in visual perception IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in cell body IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell body ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum lumen IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum lumen ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in endoplasmic reticulum membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in intracellular membrane-bounded organelle IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    retinol dehydrogenase 5
    Names
    11-cis RDH
    11-cis RoDH
    11-cis retinol dehydrogenase
    9-cis-retinol dehydrogenase
    cis-retinol dehydrogenase
    retinol dehydrogenase type 5
    NP_001345456.1
    NP_598767.1
    XP_006513448.1
    XP_036011599.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001358527.2NP_001345456.1  retinol dehydrogenase 5 isoform b

      Status: VALIDATED

      Source sequence(s)
      AC122380
      Consensus CDS
      CCDS24298.1
      UniProtKB/Swiss-Prot
      O55240
      Conserved Domains (1) summary
      cl25409
      Location:30306
      SDR; Short-chain dehydrogenases/reductases (SDR)
    2. NM_001428782.1NP_001415711.1  retinol dehydrogenase 5 isoform a

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3), as well as variant 4, encodes the longest isoform (a).
      Source sequence(s)
      AC122380
    3. NM_001428783.1NP_001415712.1  retinol dehydrogenase 5 isoform a

      Status: VALIDATED

      Source sequence(s)
      AC122380
    4. NM_001428784.1NP_001415713.1  retinol dehydrogenase 5 isoform c

      Status: VALIDATED

      Source sequence(s)
      AC122380
      UniProtKB/TrEMBL
      D3YZQ7, Q8BSF7
    5. NM_134006.6NP_598767.1  retinol dehydrogenase 5 isoform b

      See identical proteins and their annotated locations for NP_598767.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1), as well as variant 2, encodes isoform b.
      Source sequence(s)
      AC122380
      Consensus CDS
      CCDS24298.1
      UniProtKB/Swiss-Prot
      O55240
      Related
      ENSMUSP00000026406.8, ENSMUST00000026406.14
      Conserved Domains (1) summary
      cl25409
      Location:30306
      SDR; Short-chain dehydrogenases/reductases (SDR)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      128749457..128755906 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513385.4XP_006513448.1  retinol dehydrogenase 5 isoform X1

      See identical proteins and their annotated locations for XP_006513448.1

      Conserved Domains (1) summary
      cl21454
      Location:30308
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_036155706.1XP_036011599.1  retinol dehydrogenase 5 isoform X1

      Conserved Domains (1) summary
      cl21454
      Location:30308
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_003948629.1 RNA Sequence