U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Rbl2 RB transcriptional corepressor like 2 [ Mus musculus (house mouse) ]

    Gene ID: 19651, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbl2provided by MGI
    Official Full Name
    RB transcriptional corepressor like 2provided by MGI
    Primary source
    MGI:MGI:105085
    See related
    Ensembl:ENSMUSG00000031666 AllianceGenome:MGI:105085
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Rb2; PRB2; p130; RBR-2
    Summary
    Predicted to enable RNA polymerase II transcription regulatory region sequence-specific DNA binding activity and promoter-specific chromatin binding activity. Predicted to be involved in cell differentiation; negative regulation of G1/S transition of mitotic cell cycle; and regulation of lipid kinase activity. Predicted to act upstream of or within negative regulation of gene expression. Located in nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system; and retina. Used to study lung small cell carcinoma; retinoblastoma; and urinary bladder cancer. Orthologous to human RBL2 (RB transcriptional corepressor like 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in testis adult (RPKM 14.0), bladder adult (RPKM 10.1) and 28 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Rbl2 in Genome Data Viewer
    Location:
    8 C4; 8 44.25 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (91796685..91850472)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (91070057..91123844)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene chromodomain helicase DNA binding protein 9 Neighboring gene predicted gene 6658 Neighboring gene STARR-positive B cell enhancer ABC_E3792 Neighboring gene STARR-positive B cell enhancer ABC_E8848 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:93594488-93594671 Neighboring gene STARR-seq mESC enhancer starr_22297 Neighboring gene predicted gene, 39221 Neighboring gene predicted gene, 22428 Neighboring gene STARR-positive B cell enhancer mm9_chr8:93657981-93658282 Neighboring gene STARR-positive B cell enhancer mm9_chr8:93671652-93671953 Neighboring gene AKT interacting protein Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:93684510-93684619 Neighboring gene karyopherin alpha 7 (importin alpha 8) pseudogene Neighboring gene predicted gene, 36243 Neighboring gene Rpgrip1-like

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (9)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables promoter-specific chromatin binding ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in chromatin organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within negative regulation of gene expression ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    involved_in regulation of cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of lipid kinase activity ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromatin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in chromosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in chromosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    retinoblastoma-like protein 2
    Names
    130 kDa retinoblastoma-associated protein
    retinoblastoma-like 2
    retinoblastoma-related protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001282000.1NP_001268929.1  retinoblastoma-like protein 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the central coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AI323872, AK160027, BY270001, CF736271
      Consensus CDS
      CCDS85581.1
      UniProtKB/TrEMBL
      A0A1B0GRM0, Q8VCD1
      Related
      ENSMUSP00000147579.2, ENSMUST00000211136.2
      Conserved Domains (3) summary
      pfam01857
      Location:788968
      RB_B; Retinoblastoma-associated protein B domain
      pfam01858
      Location:371563
      RB_A; Retinoblastoma-associated protein A domain
      pfam11934
      Location:101210
      DUF3452; Domain of unknown function (DUF3452)
    2. NM_001282001.1NP_001268930.1  retinoblastoma-like protein 2 isoform 3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the central coding region, compared to variant 1. The encoded isoform (3) is shorter, compared to isoform 1.
      Source sequence(s)
      AI323872, AK160027, BY270001, CF736271
      Consensus CDS
      CCDS85580.1
      UniProtKB/TrEMBL
      A0A1B0GR06, Q8VCD1
      Related
      ENSMUSP00000147327.2, ENSMUST00000209518.2
      Conserved Domains (3) summary
      pfam01857
      Location:8211001
      RB_B; Retinoblastoma-associated protein B domain
      pfam01858
      Location:414596
      RB_A; Retinoblastoma-associated protein A domain
      pfam11934
      Location:101233
      DUF3452; Domain of unknown function (DUF3452)
    3. NM_011250.4NP_035380.3  retinoblastoma-like protein 2 isoform 1

      See identical proteins and their annotated locations for NP_035380.3

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AI323872, AK160027, BY270001, CF736271
      Consensus CDS
      CCDS22518.1
      UniProtKB/Swiss-Prot
      Q3TVP8, Q64700
      UniProtKB/TrEMBL
      Q8VCD1
      Related
      ENSMUSP00000034091.8, ENSMUST00000034091.8
      Conserved Domains (3) summary
      pfam01857
      Location:8311011
      RB_B; Retinoblastoma-associated protein B domain
      pfam01858
      Location:414606
      RB_A; Retinoblastoma-associated protein A domain
      pfam11934
      Location:101233
      DUF3452; Domain of unknown function (DUF3452)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      91796685..91850472
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)