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    Zfp385b zinc finger protein 385B [ Mus musculus (house mouse) ]

    Gene ID: 241494, updated on 9-Dec-2024

    Summary

    Official Symbol
    Zfp385bprovided by MGI
    Official Full Name
    zinc finger protein 385Bprovided by MGI
    Primary source
    MGI:MGI:2444734
    See related
    Ensembl:ENSMUSG00000027016 AllianceGenome:MGI:2444734
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Zfp533; Znf385b; B830010L13Rik; C130013B13Rik
    Summary
    Predicted to enable p53 binding activity. Predicted to be involved in intrinsic apoptotic signaling pathway by p53 class mediator. Predicted to be active in nucleus. Is expressed in central nervous system; heart; limb bud; and retina. Orthologous to human ZNF385B (zinc finger protein 385B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 5.5), frontal lobe adult (RPKM 4.4) and 22 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Zfp385b in Genome Data Viewer
    Location:
    2 C3; 2 45.94 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (77240966..77648050, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (77410622..77817706, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_04908 Neighboring gene predicted gene, 35317 Neighboring gene STARR-seq mESC enhancer starr_04909 Neighboring gene proteasome (prosome, macropain) subunit, beta type 3 pseudogene Neighboring gene STARR-seq mESC enhancer starr_04910 Neighboring gene STARR-seq mESC enhancer starr_04911 Neighboring gene STARR-seq mESC enhancer starr_04912 Neighboring gene predicted gene 13944 Neighboring gene STARR-seq mESC enhancer starr_04913 Neighboring gene STARR-seq mESC enhancer starr_04914 Neighboring gene ribosomal protein S3 pseudogene Neighboring gene predicted gene, 17927 Neighboring gene STARR-seq mESC enhancer starr_04915 Neighboring gene STARR-seq mESC enhancer starr_04916 Neighboring gene predicted gene, 35431 Neighboring gene STARR-seq mESC enhancer starr_04917 Neighboring gene CWC22 spliceosome-associated protein Neighboring gene STARR-positive B cell enhancer ABC_E10118 Neighboring gene ribosomal protein L7A pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in intrinsic apoptotic signaling pathway by p53 class mediator ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    zinc finger protein 385B
    Names
    zinc finger protein 533

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001113399.1NP_001106870.1  zinc finger protein 385B isoform 2

      See identical proteins and their annotated locations for NP_001106870.1

      Status: VALIDATED

      Source sequence(s)
      AI851853, AK050293, BC048543
      Consensus CDS
      CCDS50612.1
      UniProtKB/TrEMBL
      G5E8Y8
      Related
      ENSMUSP00000126801.2, ENSMUST00000171063.8
      Conserved Domains (2) summary
      sd00020
      Location:211273
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:273296
      zf-met; Zinc-finger of C2H2 type
    2. NM_001113400.1NP_001106871.1  zinc finger protein 385B isoform 3

      See identical proteins and their annotated locations for NP_001106871.1

      Status: VALIDATED

      Source sequence(s)
      AI851853, AK050293
      Consensus CDS
      CCDS50611.1
      UniProtKB/Swiss-Prot
      Q8BXJ8
      Related
      ENSMUSP00000107461.3, ENSMUST00000111830.9
      Conserved Domains (2) summary
      sd00020
      Location:185247
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:247270
      zf-met; Zinc-finger of C2H2 type
    3. NM_001363039.1NP_001349968.1  zinc finger protein 385B isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL845547, AL928537
      Conserved Domains (2) summary
      sd00020
      Location:206268
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:267291
      zf-met; Zinc-finger of C2H2 type
    4. NM_178723.6NP_848838.2  zinc finger protein 385B isoform 1

      See identical proteins and their annotated locations for NP_848838.2

      Status: VALIDATED

      Source sequence(s)
      AI851853, AK046798, AK050293, AK149352, BC132352
      Consensus CDS
      CCDS16164.1
      UniProtKB/Swiss-Prot
      Q8BWQ7, Q8BXJ8
      UniProtKB/TrEMBL
      A2AS57
      Related
      ENSMUSP00000107462.2, ENSMUST00000111831.8
      Conserved Domains (2) summary
      sd00020
      Location:299361
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:361384
      zf-met; Zinc-finger of C2H2 type

    RNA

    1. NR_156434.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928537, BX520058
    2. NR_156435.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AL928537

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      77240966..77648050 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499456.3XP_006499519.1  zinc finger protein 385B isoform X3

      Conserved Domains (2) summary
      sd00020
      Location:312374
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:374397
      zf-met; Zinc-finger of C2H2 type
    2. XM_006499455.3XP_006499518.1  zinc finger protein 385B isoform X1

      Conserved Domains (2) summary
      sd00020
      Location:341403
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:403426
      zf-met; Zinc-finger of C2H2 type
    3. XM_030251112.1XP_030106972.1  zinc finger protein 385B isoform X11

      Conserved Domains (2) summary
      sd00020
      Location:345407
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:407430
      zf-met; Zinc-finger of C2H2 type
    4. XM_030251099.1XP_030106959.1  zinc finger protein 385B isoform X8

      Conserved Domains (2) summary
      sd00020
      Location:224286
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:286309
      zf-met; Zinc-finger of C2H2 type
    5. XM_006499458.4XP_006499521.1  zinc finger protein 385B isoform X5

      Conserved Domains (2) summary
      sd00020
      Location:253315
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:315338
      zf-met; Zinc-finger of C2H2 type
    6. XM_006499460.5XP_006499523.1  zinc finger protein 385B isoform X6

      Conserved Domains (2) summary
      sd00020
      Location:248310
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:310333
      zf-met; Zinc-finger of C2H2 type
    7. XM_036161862.1XP_036017755.1  zinc finger protein 385B isoform X2

      Conserved Domains (2) summary
      sd00020
      Location:306368
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:367391
      zf-met; Zinc-finger of C2H2 type
    8. XM_006499457.5XP_006499520.1  zinc finger protein 385B isoform X4

      Conserved Domains (2) summary
      sd00020
      Location:256318
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:318341
      zf-met; Zinc-finger of C2H2 type
    9. XM_030251103.1XP_030106963.1  zinc finger protein 385B isoform X9

      Conserved Domains (2) summary
      sd00020
      Location:198260
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:260283
      zf-met; Zinc-finger of C2H2 type
    10. XM_036161868.1XP_036017761.1  zinc finger protein 385B isoform X7

      Conserved Domains (2) summary
      sd00020
      Location:227289
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:288312
      zf-met; Zinc-finger of C2H2 type
    11. XM_006499462.5XP_006499525.1  zinc finger protein 385B isoform X7

      See identical proteins and their annotated locations for XP_006499525.1

      Conserved Domains (2) summary
      sd00020
      Location:227289
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:288312
      zf-met; Zinc-finger of C2H2 type
    12. XM_006499464.2XP_006499527.1  zinc finger protein 385B isoform X10

      Conserved Domains (2) summary
      sd00020
      Location:213235
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam12874
      Location:3558
      zf-met; Zinc-finger of C2H2 type