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    Cblb Casitas B-lineage lymphoma b [ Mus musculus (house mouse) ]

    Gene ID: 208650, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cblbprovided by MGI
    Official Full Name
    Casitas B-lineage lymphoma bprovided by MGI
    Primary source
    MGI:MGI:2146430
    See related
    Ensembl:ENSMUSG00000022637 AllianceGenome:MGI:2146430
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cbl-b
    Summary
    Predicted to enable receptor tyrosine kinase binding activity and ubiquitin protein ligase activity. Involved in regulation of platelet-derived growth factor receptor-alpha signaling pathway; regulation of postsynaptic neurotransmitter receptor internalization; and regulation protein catabolic process at postsynapse. Acts upstream of or within several processes, including negative regulation of CD4-positive, alpha-beta T cell proliferation; positive regulation of T cell anergy; and positive regulation of protein metabolic process. Is active in glutamatergic synapse and postsynapse. Is expressed in brain; extrinsic ocular muscle; and incisor. Human ortholog(s) of this gene implicated in lung non-small cell carcinoma; stomach carcinoma; and type 1 diabetes mellitus. Orthologous to human CBLB (Cbl proto-oncogene B). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 7.7), CNS E14 (RPKM 6.1) and 28 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Cblb in Genome Data Viewer
    Location:
    16 B5; 16 32.88 cM
    Exon count:
    21
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 16 NC_000082.7 (51851593..52028410)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 16 NC_000082.6 (52031230..52208047)

    Chromosome 16 - NC_000082.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 57632 Neighboring gene STARR-seq mESC enhancer starr_41004 Neighboring gene STARR-seq mESC enhancer starr_41005 Neighboring gene STARR-seq mESC enhancer starr_41006 Neighboring gene predicted gene, 29686 Neighboring gene STARR-positive B cell enhancer ABC_E2463 Neighboring gene STARR-positive B cell enhancer ABC_E7459 Neighboring gene STARR-positive B cell enhancer ABC_E5546 Neighboring gene STARR-seq mESC enhancer starr_41007 Neighboring gene STARR-seq mESC enhancer starr_41008 Neighboring gene STARR-positive B cell enhancer mm9_chr16:52149538-52149839 Neighboring gene predicted gene, 23513 Neighboring gene STARR-positive B cell enhancer mm9_chr16:52182153-52182454 Neighboring gene STARR-positive B cell enhancer ABC_E10910 Neighboring gene activated leukocyte cell adhesion molecule Neighboring gene predicted gene, 32597 Neighboring gene predicted gene, 41461

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphotyrosine residue binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables receptor tyrosine kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin-protein transferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of CD4-positive, alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell activation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of T cell anergy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within immune response IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within intracellular signal transduction IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of CD4-positive, alpha-beta T cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of T cell receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of epidermal growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within peptidyl-amino acid modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of T cell anergy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of protein ubiquitination IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within regulation of GTPase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of T cell receptor signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    acts_upstream_of_or_within regulation of cell adhesion IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of platelet-derived growth factor receptor-alpha signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of postsynaptic neurotransmitter receptor internalization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of protein binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation protein catabolic process at postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in membrane raft IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase CBL-B
    Names
    RING-type E3 ubiquitin transferase CBL-B
    SH3-binding protein CBL-B
    casitas B-lineage lymphoma proto-oncogene b
    signal transduction protein CBL-B
    NP_001028410.1
    XP_006522010.1
    XP_006522011.1
    XP_006522012.1
    XP_006522013.1
    XP_006522014.1
    XP_006522015.1
    XP_036015751.1
    XP_036015752.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001033238.1NP_001028410.1  E3 ubiquitin-protein ligase CBL-B

      Status: VALIDATED

      Source sequence(s)
      AK147367, AK161486, AK164519, CJ102432, CJ110973, CJ244362
      Consensus CDS
      CCDS37355.1
      UniProtKB/TrEMBL
      B9EKI5
      Related
      ENSMUSP00000110115.2, ENSMUST00000114471.3
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:887927
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:354419
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44164
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000082.7 Reference GRCm39 C57BL/6J

      Range
      51851593..52028410
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006521950.4XP_006522013.1  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/Swiss-Prot
      E9QMY2, Q3TTA7
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:931971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:354419
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44165
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    2. XM_006521949.1XP_006522012.1  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/Swiss-Prot
      E9QMY2, Q3TTA7
      Related
      ENSMUSP00000153787.2, ENSMUST00000227879.2
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:931971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:354419
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44165
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    3. XM_036159859.1XP_036015752.1  E3 ubiquitin-protein ligase CBL-B isoform X3

      UniProtKB/TrEMBL
      B9EKI5
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:887927
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:354419
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44164
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    4. XM_006521948.1XP_006522011.1  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/Swiss-Prot
      E9QMY2, Q3TTA7
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:931971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:354419
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44165
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    5. XM_006521951.1XP_006522014.1  E3 ubiquitin-protein ligase CBL-B isoform X3

      UniProtKB/TrEMBL
      B9EKI5
      Related
      ENSMUSP00000154583.2, ENSMUST00000227062.2
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:887927
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:354419
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44164
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    6. XM_006521947.1XP_006522010.1  E3 ubiquitin-protein ligase CBL-B isoform X1

      UniProtKB/Swiss-Prot
      E9QMY2, Q3TTA7
      Related
      ENSMUSP00000154755.2, ENSMUST00000226593.2
      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:931971
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:354419
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44165
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    7. XM_036159858.1XP_036015751.1  E3 ubiquitin-protein ligase CBL-B isoform X2

      Conserved Domains (5) summary
      cd09920
      Location:248344
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:891931
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:354419
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02262
      Location:44164
      Cbl_N; CBL proto-oncogene N-terminal domain 1
      pfam02761
      Location:171254
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain
    8. XM_006521952.5XP_006522015.1  E3 ubiquitin-protein ligase CBL-B isoform X4

      UniProtKB/Swiss-Prot
      Q3TTA7
      Related
      ENSMUSP00000153753.2, ENSMUST00000227756.2
      Conserved Domains (4) summary
      cd09920
      Location:96192
      SH2_Cbl-b_TKB; Src homology 2 (SH2) domain found in the Cbl-b TKB domain
      cd14392
      Location:779819
      UBA_Cbl-b; UBA domain found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      cd16709
      Location:202267
      RING-HC_Cbl-b; RING finger, HC subclass, found in E3 ubiquitin-protein ligase Cbl-b and similar proteins
      pfam02761
      Location:19102
      Cbl_N2; CBL proto-oncogene N-terminus, EF hand-like domain