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    Lrrc41 leucine rich repeat containing 41 [ Mus musculus (house mouse) ]

    Gene ID: 230654, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Lrrc41provided by MGI
    Official Full Name
    leucine rich repeat containing 41provided by MGI
    Primary source
    MGI:MGI:2441984
    See related
    Ensembl:ENSMUSG00000028703 AllianceGenome:MGI:2441984
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    MUF1; D630045E04Rik; D730026A16Rik
    Summary
    Enables identical protein binding activity. Predicted to be involved in protein ubiquitination. Located in cytoplasm and nucleus. Is expressed in several structures, including central nervous system and retina. Orthologous to human LRRC41 (leucine rich repeat containing 41). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 72.1), testis adult (RPKM 51.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Lrrc41 in Genome Data Viewer
    Location:
    4 D1; 4 53.1 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (115932466..115954306)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (116075269..116097109)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene NOL1/NOP2/Sun domain family, member 4 Neighboring gene STARR-positive B cell enhancer ABC_E3503 Neighboring gene STARR-positive B cell enhancer ABC_E4647 Neighboring gene predicted gene 12854 Neighboring gene ubiquinol-cytochrome c reductase hinge protein Neighboring gene predicted gene, 52704 Neighboring gene RAD54 like (S. cerevisiae) Neighboring gene RIKEN cDNA 2510003B16 gene Neighboring gene STARR-positive B cell enhancer ABC_E10248 Neighboring gene STARR-seq mESC enhancer starr_11132 Neighboring gene leucine rich adaptor protein 1 Neighboring gene protein O-linked mannose beta 1,2-N-acetylglucosaminyltransferase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein. Schenková K, et al. J Mol Biol, 2012 Oct 5. PMID 22709582
    2. Muf1, a novel Elongin BC-interacting leucine-rich repeat protein that can assemble with Cul5 and Rbx1 to reconstitute a ubiquitin ligase. Kamura T, et al. J Biol Chem, 2001 Aug 10. PMID 11384984
    3. VHL-box and SOCS-box domains determine binding specificity for Cul2-Rbx1 and Cul5-Rbx2 modules of ubiquitin ligases. Kamura T, et al. Genes Dev, 2004 Dec 15. PMID 15601820, Free PMC Article
    4. Single-cell RNA-Seq reveals a highly coordinated transcriptional program in mouse germ cells during primordial follicle formation. He Y, et al. Aging Cell, 2021 Jul. PMID 34174788, Free PMC Article
    5. The SOCS box: a tale of destruction and degradation. Kile BT, et al. Trends Biochem Sci, 2002 May. PMID 12076535

    See all (22) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The authors identified MUF1 as the first substrate for RhoBTB-Cul3 ubiquitin ligase complexes.
      Title: MUF1/leucine-rich repeat containing 41 (LRRC41), a substrate of RhoBTB-dependent cullin 3 ubiquitin ligase complexes, is a predominantly nuclear dimeric protein.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC38941

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    leucine-rich repeat-containing protein 41
    Names
    protein Muf1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_153521.2 → NP_705741.3  leucine-rich repeat-containing protein 41

      See identical proteins and their annotated locations for NP_705741.3

      Status: VALIDATED

      Source sequence(s)
      AK052762, BB619031, BQ032399, BY033356
      Consensus CDS
      CCDS84786.1
      UniProtKB/Swiss-Prot
      A2A911, Q3U3S2, Q6IQY7, Q8K1C9, Q91VX4
      Related
      ENSMUSP00000030471.9, ENSMUST00000030471.9
      Conserved Domains (2) summary
      cd00116
      Location:598 → 744
      LRR_RI; Leucine-rich repeats (LRRs), ribonuclease inhibitor (RI)-like subfamily. LRRs are 20-29 residue sequence motifs present in many proteins that participate in protein-protein interactions and have different functions and cellular locations. LRRs correspond ...
      pfam06365
      Location:581 → 658
      CD34_antigen; CD34/Podocalyxin family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      115932466..115954306
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030253441.2 → XP_030109301.1  leucine-rich repeat-containing protein 41 isoform X1

    2. XM_030253442.1 → XP_030109302.1  leucine-rich repeat-containing protein 41 isoform X2

    3. XM_036164035.1 → XP_036019928.1  leucine-rich repeat-containing protein 41 isoform X2

    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8K1C9.3 GenPept UniProtKB/Swiss-Prot:Q8K1C9

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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