Ifit2 interferon-induced protein with tetratricopeptide repeats 2 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Ifit2provided by MGI
Official Full Name: interferon-induced protein with tetratricopeptide repeats 2provided by MGI
Primary source: MGI:MGI:99449
See related: Ensembl:ENSMUSG00000045932 AllianceGenome:MGI:99449
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: P54; Ifi54; GARG-39; IFI-54K
Summary: Predicted to enable RNA binding activity. Involved in response to virus. Acts upstream of or within antiviral innate immune response and cellular response to interferon-alpha. Predicted to be located in endoplasmic reticulum. Predicted to be active in cytosol. Is expressed in several structures, including alimentary system; brain; genitourinary system; integumental system; and respiratory system. Orthologous to human IFIT2 (interferon induced protein with tetratricopeptide repeats 2). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in liver E18 (RPKM 2.6), bladder adult (RPKM 2.3) and 22 other tissues See more
Orthologs: human all
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Genomic context

Location:: 19 C1; 19 29.73 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	19	NC_000085.7 (34527961..34553934)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	19	NC_000085.6 (34550550..34576534)

Chromosome 19 - NC_000085.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

IFIT2 mediates iron retention and cholesterol efflux in atherosclerosis.
Title: IFIT2 mediates iron retention and cholesterol efflux in atherosclerosis.
The interferon-induced protein, IFIT2, requires RNA-binding activity and neuronal expression to protect mice from intranasal vesicular stomatitis virus infection.
Title: The interferon-induced protein, IFIT2, requires RNA-binding activity and neuronal expression to protect mice from intranasal vesicular stomatitis virus infection.
Ifit2 restricts murine coronavirus spread to the spinal cord white matter and its associated myelin pathology.
Title: Ifit2 restricts murine coronavirus spread to the spinal cord white matter and its associated myelin pathology.
IFIT2-depleted metastatic oral squamous cell carcinoma cells induce muscle atrophy and cancer cachexia in mice.
Title: IFIT2-depleted metastatic oral squamous cell carcinoma cells induce muscle atrophy and cancer cachexia in mice.
Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs.
Title: Influenza virus repurposes the antiviral protein IFIT2 to promote translation of viral mRNAs.
Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection.
Title: Ifit2 deficiency restricts microglial activation and leukocyte migration following murine coronavirus (m-CoV) CNS infection.
The authors provide evidence that IFIT2 increases the pathological effects of invasive Candida albicans and that administration of interferon-beta has deleterious effects during infection.
Title: Pathogenic Effects of IFIT2 and Interferon-β during Fatal Systemic Candida albicans Infection.
this study shows that activation of IRF3 contributes to IFN-gamma and ISG54 expression during the immune responses to B16F10 tumor growth
Title: Activation of IRF3 contributes to IFN-γ and ISG54 expression during the immune responses to B16F10 tumor growth.
Ifit2 exerts its antiviral effect mainly at the level of viral replication, as opposed to functioning as a mechanism that restricts viral entry/egress or transports rabies virus particles through axons.
Title: Ifit2 Is a Restriction Factor in Rabies Virus Pathogenicity.
the mechanism for the observed differential induction of the mouse Ifit1, Ifit2, and Ifit3 genes in B cells and demonstrated that the repressive effect of the transcription factor interferon regulatory factor 8 (IRF8), which is highly expressed in B cells, played an essential role in this regulation.
Title: Interferon Regulatory Factor 8 (IRF8) Impairs Induction of Interferon Induced with Tetratricopeptide Repeat Motif (IFIT) Gene Family Members.

Submit: New GeneRIF Correction See all GeneRIFs (22)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (3) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

U43085 (e-PCR)
- UniSTS:163614

PMC299790P1 (e-PCR)
- UniSTS:272461

Ifit2 (e-PCR), detects polymorphism
- UniSTS:506993

AV302338 (e-PCR)
- UniSTS:181224

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables RNA binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within antiviral innate immune response	IDA Inferred from Direct Assay more info	PubMed
involved_in antiviral innate immune response	ISO Inferred from Sequence Orthology more info
involved_in apoptotic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within cellular response to interferon-alpha	IDA Inferred from Direct Assay more info	PubMed
involved_in defense response to virus	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of protein binding	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of apoptotic process	ISS Inferred from Sequence or Structural Similarity more info
involved_in response to virus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to virus	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytoplasm	ISS Inferred from Sequence or Structural Similarity more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info

General protein information

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Preferred Names: interferon-induced protein with tetratricopeptide repeats 2

Names: IFIT-2; glucocorticoid-attenuated response gene 39 protein; interferon-induced 54 kDa protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001355262.1 → NP_001342191.1 interferon-induced protein with tetratricopeptide repeats 2

Status: VALIDATED

Source sequence(s)

AC102249

Consensus CDS

CCDS29761.1

UniProtKB/Swiss-Prot

Q62385, Q64112

UniProtKB/TrEMBL

Q6GTM0

Conserved Domains (2) summary

TIGR02917
Location:145 → 359

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:242 → 270

TPR; TPR repeat [structural motif]
NM_008332.3 → NP_032358.1 interferon-induced protein with tetratricopeptide repeats 2

See identical proteins and their annotated locations for NP_032358.1

Status: VALIDATED

Source sequence(s)

BC050835, BF730115, CJ044173, U43085

Consensus CDS

CCDS29761.1

UniProtKB/Swiss-Prot

Q62385, Q64112

UniProtKB/TrEMBL

Q6GTM0

Related

ENSMUSP00000099890.4, ENSMUST00000102826.4

Conserved Domains (2) summary

TIGR02917
Location:145 → 359

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:242 → 270

TPR; TPR repeat [structural motif]

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000085.7 Reference GRCm39 C57BL/6J

Range

34527961..34553934

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_036161447.1 → XP_036017340.1 interferon-induced protein with tetratricopeptide repeats 2 isoform X1

UniProtKB/Swiss-Prot

Q62385, Q64112

UniProtKB/TrEMBL

Q6GTM0

Conserved Domains (2) summary

TIGR02917
Location:145 → 359

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:242 → 270

TPR; TPR repeat [structural motif]
XM_006526705.4 → XP_006526768.1 interferon-induced protein with tetratricopeptide repeats 2 isoform X1

See identical proteins and their annotated locations for XP_006526768.1

UniProtKB/Swiss-Prot

Q62385, Q64112

UniProtKB/TrEMBL

Q6GTM0

Conserved Domains (2) summary

TIGR02917
Location:145 → 359

PEP_TPR_lipo; putative PEP-CTERM system TPR-repeat lipoprotein

sd00006
Location:242 → 270

TPR; TPR repeat [structural motif]