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    Ces1a carboxylesterase 1A [ Mus musculus (house mouse) ]

    Gene ID: 244595, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ces1aprovided by MGI
    Official Full Name
    carboxylesterase 1Aprovided by MGI
    Primary source
    MGI:MGI:3648919
    See related
    Ensembl:ENSMUSG00000071047 AllianceGenome:MGI:3648919
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Ces1l; Gm4976; EG244595
    Summary
    Predicted to enable carboxylesterase activity and sterol ester esterase activity. Predicted to be involved in several processes, including cellular response to cholesterol; cholesterol homeostasis; and regulation of steroid metabolic process. Predicted to be located in cytoplasm. Predicted to be active in endoplasmic reticulum and lipid droplet. Is expressed in ductus deferens and testis. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Ces1a in Genome Data Viewer
    Location:
    8 C5; 8 44.99 cM
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (93746842..93774820, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (93020214..93048192, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene predicted gene 2947 Neighboring gene solute carrier family 6 (neurotransmitter transporter, noradrenalin), member 2 Neighboring gene STARR-seq mESC enhancer starr_22328 Neighboring gene carboxylesterase 1B Neighboring gene STARR-seq mESC enhancer starr_22331 Neighboring gene carboxylesterase 1C

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate. Jin Q, et al. Chem Biol Interact, 2022 Dec 1. PMID 36174736
    2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. Holmes RS, et al. Mamm Genome, 2010 Oct. PMID 20931200, Free PMC Article
    3. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    4. Genetic determinants of micronucleus formation in vivo. Adams DJ, et al. Nature, 2024 Mar. PMID 38355793, Free PMC Article
    5. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate.
      Title: Deciphering the species differences in CES1A-mediated hydrolytic metabolism by using a bioluminescence substrate.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC102259

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylesterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables sterol ester esterase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    involved_in cellular response to cholesterol ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cellular response to low-density lipoprotein particle stimulus ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol homeostasis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in epithelial cell differentiation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in lipid catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in medium-chain fatty acid metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cholesterol storage ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol efflux ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of cholesterol metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of bile acid biosynthetic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of bile acid secretion ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in reverse cholesterol transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in endoplasmic reticulum IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in lipid droplet IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in lipid droplet ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    carboxylesterase 1-like

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001013764.2 → NP_001013786.2  carboxylesterase 1-like precursor

      Status: VALIDATED

      Source sequence(s)
      AC140217, BC089371
      Consensus CDS
      CCDS22526.1
      UniProtKB/TrEMBL
      E9PYP1, Q5FWH4
      Related
      ENSMUSP00000092836.5, ENSMUST00000095211.5
      Conserved Domains (1) summary
      cd00312
      Location:25 → 536
      Esterase_lipase; Esterases and lipases (includes fungal lipases, cholinesterases, etc.) These enzymes act on carboxylic esters (EC: 3.1.1.-). The catalytic apparatus involves three residues (catalytic triad): a serine, a glutamate or aspartate and a histidine.These ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      93746842..93774820 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243550.2 → XP_030099410.1  carboxylesterase 1-like isoform X2

      Conserved Domains (1) summary
      pfam00135
      Location:26 → 436
      COesterase; Carboxylesterase family

    2. XM_017312820.3 → XP_017168309.1  carboxylesterase 1-like isoform X1

      Conserved Domains (1) summary
      pfam00135
      Location:29 → 440
      COesterase; Carboxylesterase family

    3. XM_006530999.3 → XP_006531062.1  carboxylesterase 1-like isoform X3

      Conserved Domains (1) summary
      pfam00135
      Location:1 → 410
      COesterase; Carboxylesterase family
    Nucleotide Protein Strain
    Heading Accession and Version

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