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    Clec4b2 C-type lectin domain family 4, member b2 [ Mus musculus (house mouse) ]

    Gene ID: 381809, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Clec4b2provided by MGI
    Official Full Name
    C-type lectin domain family 4, member b2provided by MGI
    Primary source
    MGI:MGI:3588267
    See related
    Ensembl:ENSMUSG00000067767 AllianceGenome:MGI:3588267
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Aplra1; mDCAR1; F830043G12Rik
    Summary
    Predicted to enable carbohydrate binding activity and pattern recognition receptor activity. Acts upstream of or within positive regulation of antigen processing and presentation. Located in external side of plasma membrane. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Low expression observed in reference dataset See more
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    Genomic context

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    See Clec4b2 in Genome Data Viewer
    Location:
    6 F2; 6 58.25 cM
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 6 NC_000072.7 (123149827..123181630)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 6 NC_000072.6 (123172868..123204671)

    Chromosome 6 - NC_000072.7Genomic Context describing neighboring genes Neighboring gene C-type lectin domain family 4, member b1 Neighboring gene C-type lectin domain family 4, member a2 Neighboring gene STARR-seq mESC enhancer starr_17270 Neighboring gene predicted gene, 22946 Neighboring gene STARR-seq mESC enhancer starr_17271 Neighboring gene peptidylprolyl isomerase A pseudogene 6_1344.1 Neighboring gene C-type lectin domain family 4, member n

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Enhanced dendritic cell-induced immune responses mediated by the novel C-type lectin receptor mDCAR1. Kaden SA, et al. J Immunol, 2009 Oct 15. PMID 19786536
    2. Identification of Clec4b as a novel regulator of bystander activation of auto-reactive T cells and autoimmune disease. Bäckdahl L, et al. PLoS Genet, 2020 Jun. PMID 32497089, Free PMC Article
    3. Identification of lectin-like receptors expressed by antigen presenting cells and neutrophils and their mapping to a novel gene complex. Flornes LM, et al. Immunogenetics, 2004 Oct. PMID 15368084
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Antisense transcription in the mammalian transcriptome. Katayama S, et al. Science, 2005 Sep 2. PMID 16141073

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    General gene information

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    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carbohydrate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables pattern recognition receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in antifungal innate immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within positive regulation of antigen processing and presentation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in external side of plasma membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    C-type lectin domain family 4, member b2
    Names
    antigen presenting cell lectin-like receptor A1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001004159.2 → NP_001004159.1  C-type lectin domain family 4, member b2

      See identical proteins and their annotated locations for NP_001004159.1

      Status: VALIDATED

      Source sequence(s)
      AC164111
      Consensus CDS
      CCDS20511.1
      UniProtKB/TrEMBL
      Q67DU8
      Related
      ENSMUSP00000085802.6, ENSMUST00000088455.6
      Conserved Domains (1) summary
      cd03590
      Location:79 → 203
      CLECT_DC-SIGN_like; C-type lectin-like domain (CTLD) of the type found in human dendritic cell (DC)-specific intercellular adhesion molecule 3-grabbing non-integrin (DC-SIGN) and the related receptor, DC-SIGN receptor (DC-SIGNR)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000072.7 Reference GRCm39 C57BL/6J

      Range
      123149827..123181630
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017321668.1 → XP_017177157.1  C-type lectin domain family 4, member b2 isoform X1

      Conserved Domains (1) summary
      cl02432
      Location:79 → 124
      CLECT; C-type lectin (CTL)/C-type lectin-like (CTLD) domain
    Nucleotide Protein Strain
    Heading Accession and Version

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