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    Daam2 dishevelled associated activator of morphogenesis 2 [ Mus musculus (house mouse) ]

    Gene ID: 76441, updated on 9-Dec-2024

    Summary

    Official Symbol
    Daam2provided by MGI
    Official Full Name
    dishevelled associated activator of morphogenesis 2provided by MGI
    Primary source
    MGI:MGI:1923691
    See related
    Ensembl:ENSMUSG00000040260 AllianceGenome:MGI:1923691
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2310016D11Rik
    Summary
    Predicted to enable actin binding activity and small GTPase binding activity. Involved in dorsal spinal cord development; negative regulation of oligodendrocyte differentiation; and regulation of Wnt signaling pathway. Acts upstream of or within determination of left/right symmetry. Is expressed in several structures, including alimentary system; central nervous system; embryo mesenchyme; genitourinary system; and limb. Human ortholog(s) of this gene implicated in familial nephrotic syndrome. Orthologous to human DAAM2 (dishevelled associated activator of morphogenesis 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cerebellum adult (RPKM 13.0), testis adult (RPKM 12.4) and 23 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Daam2 in Genome Data Viewer
    Location:
    17 C; 17 25.5 cM
    Exon count:
    30
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 17 NC_000083.7 (49763050..49871517, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 17 NC_000083.6 (49456022..49564459, complement)

    Chromosome 17 - NC_000083.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 41594 Neighboring gene STARR-positive B cell enhancer ABC_E1944 Neighboring gene CapStarr-seq enhancer MGSCv37_chr17:49568292-49568475 Neighboring gene molybdenum cofactor synthesis 1 Neighboring gene predicted gene, 52301 Neighboring gene kinesin family member 6 Neighboring gene VISTA enhancer mm276 Neighboring gene STARR-seq mESC enhancer starr_42779 Neighboring gene STARR-seq mESC enhancer starr_42780 Neighboring gene STARR-seq mESC enhancer starr_42781 Neighboring gene STARR-seq mESC enhancer starr_42782 Neighboring gene predicted gene 16555 Neighboring gene STARR-seq mESC enhancer starr_42783 Neighboring gene STARR-seq mESC enhancer starr_42784 Neighboring gene STARR-seq mESC enhancer starr_42785 Neighboring gene predicted gene, 19465

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables actin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in actin cytoskeleton organization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within determination of left/right symmetry IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in dorsal spinal cord development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of oligodendrocyte differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of oligodendrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in podocyte cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in podocyte cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell migration ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin cytoskeleton organization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of actin filament polymerization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of actin filament polymerization ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of filopodium assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of filopodium assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of non-canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of non-canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    disheveled-associated activator of morphogenesis 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001008231.2NP_001008232.2  disheveled-associated activator of morphogenesis 2 isoform 1

      See identical proteins and their annotated locations for NP_001008232.2

      Status: VALIDATED

      Source sequence(s)
      AC165258, AK009382, AY426536, BC050043
      Consensus CDS
      CCDS37648.1
      UniProtKB/Swiss-Prot
      E9QNU9, Q6TAB7, Q80U19, Q810J5
      Related
      ENSMUSP00000052085.7, ENSMUST00000057610.8
      Conserved Domains (3) summary
      pfam02181
      Location:5951016
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
    2. NM_001379371.1NP_001366300.1  disheveled-associated activator of morphogenesis 2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124748, AC165258
      Conserved Domains (3) summary
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
    3. NM_001379372.1NP_001366301.1  disheveled-associated activator of morphogenesis 2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC124748, AC165258
      Conserved Domains (3) summary
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595968
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000083.7 Reference GRCm39 C57BL/6J

      Range
      49763050..49871517 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006525090.5XP_006525153.1  disheveled-associated activator of morphogenesis 2 isoform X2

      Conserved Domains (3) summary
      pfam02181
      Location:587988
      FH2; Formin Homology 2 Domain
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
    2. XM_006525083.5XP_006525146.1  disheveled-associated activator of morphogenesis 2 isoform X1

      See identical proteins and their annotated locations for XP_006525146.1

      Conserved Domains (3) summary
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
    3. XM_036160827.1XP_036016720.1  disheveled-associated activator of morphogenesis 2 isoform X4

      Conserved Domains (3) summary
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:587960
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
    4. XM_006525089.5XP_006525152.1  disheveled-associated activator of morphogenesis 2 isoform X1

      See identical proteins and their annotated locations for XP_006525152.1

      Conserved Domains (3) summary
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
    5. XM_036160826.1XP_036016719.1  disheveled-associated activator of morphogenesis 2 isoform X3

      Conserved Domains (3) summary
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595968
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
    6. XM_006525084.5XP_006525147.1  disheveled-associated activator of morphogenesis 2 isoform X1

      See identical proteins and their annotated locations for XP_006525147.1

      Conserved Domains (3) summary
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
    7. XM_006525085.5XP_006525148.1  disheveled-associated activator of morphogenesis 2 isoform X1

      See identical proteins and their annotated locations for XP_006525148.1

      Conserved Domains (3) summary
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
    8. XM_006525086.4XP_006525149.1  disheveled-associated activator of morphogenesis 2 isoform X1

      See identical proteins and their annotated locations for XP_006525149.1

      Conserved Domains (3) summary
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam02181
      Location:595996
      FH2; Formin Homology 2 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
    9. XM_036160828.1XP_036016721.1  disheveled-associated activator of morphogenesis 2 isoform X5

      Conserved Domains (3) summary
      pfam06367
      Location:231435
      Drf_FH3; Diaphanous FH3 Domain
      pfam06371
      Location:43228
      Drf_GBD; Diaphanous GTPase-binding Domain
      cl19758
      Location:595651
      FH2; Formin Homology 2 Domain

    RNA

    1. XR_004939600.1 RNA Sequence

    2. XR_004939598.1 RNA Sequence

    3. XR_004939599.1 RNA Sequence