Parp10 poly (ADP-ribose) polymerase family, member 10 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Parp10provided by MGI
Official Full Name: poly (ADP-ribose) polymerase family, member 10provided by MGI
Primary source: MGI:MGI:3712326
See related: Ensembl:ENSMUSG00000063268 AllianceGenome:MGI:3712326
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: ARTD10; PARP-10
Summary: Predicted to enable several functions, including K63-linked polyubiquitin modification-dependent protein binding activity; NAD+-protein poly-ADP-ribosyltransferase activity; and transcription corepressor activity. Predicted to be involved in several processes, including negative regulation of protein K63-linked ubiquitination; post-translational protein modification; and regulation of gene expression. Predicted to be located in Golgi apparatus; cytosol; and nucleolus. Predicted to be active in cytoplasm and nucleus. Orthologous to human PARP10 (poly(ADP-ribose) polymerase family member 10). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Broad expression in thymus adult (RPKM 25.0), adrenal adult (RPKM 24.2) and 20 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 35.57 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (76117195..76127640, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (76232995..76243440, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA.
Title: The piRNA CHAPIR regulates cardiac hypertrophy by controlling METTL3-dependent N(6)-methyladenosine methylation of Parp10 mRNA.
murine Artd8 macrodomain constructs can serve as a tool to evaluate intracellular ARTD10 auto-modification levels using the described methods, while the human ARTD8 macrodomains are less suited because of ADPr-independent binding to ARTD10. Protocols for co-immunoprecipitation and co-localization experiments are described in detail.
Title: Assessment of Intracellular Auto-Modification Levels of ARTD10 Using Mono-ADP-Ribose-Specific Macrodomains 2 and 3 of Murine Artd8.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (1) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables DNA-binding transcription factor binding	ISO Inferred from Sequence Orthology more info
enables K63-linked polyubiquitin modification-dependent protein binding	IEA Inferred from Electronic Annotation more info
enables K63-linked polyubiquitin modification-dependent protein binding	ISO Inferred from Sequence Orthology more info
enables NAD+-histone H2BE18 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE2 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-histone H2BE35 glutamate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein ADP-ribosyltransferase activity	ISS Inferred from Sequence or Structural Similarity more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein poly-ADP-ribosyltransferase activity	ISO Inferred from Sequence Orthology more info
enables NAD+-protein-aspartate ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables NAD+-protein-lysine ADP-ribosyltransferase activity	IEA Inferred from Electronic Annotation more info
enables nucleotidyltransferase activity	IEA Inferred from Electronic Annotation more info
enables transcription corepressor activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in chromatin organization	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of NF-kappaB transcription factor activity	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of fibroblast proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of fibroblast proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of gene expression	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of gene expression	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of gene expression	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of protein K63-linked ubiquitination	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of protein K63-linked ubiquitination	ISO Inferred from Sequence Orthology more info
involved_in protein auto-ADP-ribosylation	IEA Inferred from Electronic Annotation more info
involved_in protein auto-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in protein poly-ADP-ribosylation	IEA Inferred from Electronic Annotation more info
involved_in protein poly-ADP-ribosylation	ISO Inferred from Sequence Orthology more info
involved_in translesion synthesis	ISO Inferred from Sequence Orthology more info
involved_in translesion synthesis	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in Golgi apparatus	IEA Inferred from Electronic Annotation more info
located_in Golgi apparatus	ISO Inferred from Sequence Orthology more info
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
located_in cytosol	IEA Inferred from Electronic Annotation more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in nucleolus	IEA Inferred from Electronic Annotation more info
located_in nucleolus	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: protein mono-ADP-ribosyltransferase PARP10

Names: ADP-ribosyltransferase diphtheria toxin-like 10; poly [ADP-ribose] polymerase 10

NP_001157047.1

EC 2.4.2.30

NP_001157048.1

EC 2.4.2.30

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001163575.1 → NP_001157047.1 protein mono-ADP-ribosyltransferase PARP10

See identical proteins and their annotated locations for NP_001157047.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the predominant transcript. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK046755, BP768925, BY742887

Consensus CDS

CCDS49650.1

UniProtKB/Swiss-Prot

F6Z9X8, Q3TLV7, Q3U6C0, Q8BSZ1, Q8C8L6, Q8CIE4, Q8R133, Q8R1U9

Related

ENSMUSP00000075110.7, ENSMUST00000075689.7

Conserved Domains (5) summary

cd01439
Location:834 → 952

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd12547
Location:9 → 79

RRM1_2_PAR10; RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase 10 (PARP-10) and similar proteins

pfam00644
Location:768 → 954

PARP; Poly(ADP-ribose) polymerase catalytic domain

cl00283
Location:755 → 876

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

cl17169
Location:194 → 242

RRM_SF; RNA recognition motif (RRM) superfamily
NM_001163576.1 → NP_001157048.1 protein mono-ADP-ribosyltransferase PARP10

See identical proteins and their annotated locations for NP_001157048.1

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same protein.

Source sequence(s)

AK046755, BB843953, BP768925

Consensus CDS

CCDS49650.1

UniProtKB/Swiss-Prot

F6Z9X8, Q3TLV7, Q3U6C0, Q8BSZ1, Q8C8L6, Q8CIE4, Q8R133, Q8R1U9

Related

ENSMUSP00000129765.2, ENSMUST00000165738.8

Conserved Domains (5) summary

cd01439
Location:834 → 952

TCCD_inducible_PARP_like; Poly(ADP-ribose) polymerases catalyse the covalent attachment of ADP-ribose units from NAD+ to itself and to a limited number of other DNA binding proteins, which decreases their affinity for DNA. Poly(ADP-ribose) polymerase is a regulatory component ...

cd12547
Location:9 → 79

RRM1_2_PAR10; RNA recognition motif 1 and 2 in poly [ADP-ribose] polymerase 10 (PARP-10) and similar proteins

pfam00644
Location:768 → 954

PARP; Poly(ADP-ribose) polymerase catalytic domain

cl00283
Location:755 → 876

ADP_ribosyl; ADP_ribosylating enzymes catalyze the transfer of ADP_ribose from NAD+ to substrates. Bacterial toxins are cytoplasmic and catalyze the transfer of a single ADP_ribose unit to eukaryotic elongation factor 2, halting protein synthesis and killing the cell. ...

cl17169
Location:194 → 242

RRM_SF; RNA recognition motif (RRM) superfamily