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    Elf5 E74-like factor 5 [ Mus musculus (house mouse) ]

    Gene ID: 13711, updated on 27-Nov-2024

    Summary

    Official Symbol
    Elf5provided by MGI
    Official Full Name
    E74-like factor 5provided by MGI
    Primary source
    MGI:MGI:1335079
    See related
    Ensembl:ENSMUSG00000027186 AllianceGenome:MGI:1335079
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    ESE-2; ESE-5; ESE-5.
    Summary
    Enables DNA-binding transcription activator activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including ectodermal cell fate commitment; mammary gland epithelial cell differentiation; and negative regulation of cell differentiation involved in embryonic placenta development. Located in cytoplasm and nucleus. Is expressed in several structures, including alimentary system; extraembryonic component; genitourinary system; integumental system; and respiratory system epithelium. Orthologous to human ELF5 (E74 like ETS transcription factor 5). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in lung adult (RPKM 8.8), mammary gland adult (RPKM 6.4) and 6 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Elf5 in Genome Data Viewer
    Location:
    2 E2; 2 54.43 cM
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103242443..103281334)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103412098..103450989)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA A930006I01 gene Neighboring gene STARR-seq mESC enhancer starr_05269 Neighboring gene cDNA sequence BC016548 Neighboring gene STARR-seq mESC enhancer starr_05270 Neighboring gene STARR-positive B cell enhancer ABC_E811 Neighboring gene catalase Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene STARR-positive B cell enhancer ABC_E7843 Neighboring gene STARR-positive B cell enhancer ABC_E812 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103408122-103408323 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene VISTA enhancer mm1312

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    ETS-related transcription factor Elf-5
    Names
    Epithelium specific Ets-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001145813.1NP_001139285.1  ETS-related transcription factor Elf-5

      See identical proteins and their annotated locations for NP_001139285.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants encode the same protein.
      Source sequence(s)
      AK132484, AL773505
      Consensus CDS
      CCDS16477.1
      UniProtKB/Swiss-Prot
      Q8VDK3, Q921H5, Q9Z2K6
      UniProtKB/TrEMBL
      Q3ULZ4, Q3V1F7
      Related
      ENSMUSP00000126941.2, ENSMUST00000164172.8
      Conserved Domains (2) summary
      cd08538
      Location:39122
      SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
      smart00413
      Location:162246
      ETS; erythroblast transformation specific domain
    2. NM_010125.3NP_034255.2  ETS-related transcription factor Elf-5

      See identical proteins and their annotated locations for NP_034255.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript. Both variants encode the same protein.
      Source sequence(s)
      AF049702, AK132484, AK145214, AL773505
      Consensus CDS
      CCDS16477.1
      UniProtKB/Swiss-Prot
      Q8VDK3, Q921H5, Q9Z2K6
      UniProtKB/TrEMBL
      Q3ULZ4, Q3V1F7
      Related
      ENSMUSP00000028609.8, ENSMUST00000028609.14
      Conserved Domains (2) summary
      cd08538
      Location:39122
      SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
      smart00413
      Location:162246
      ETS; erythroblast transformation specific domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      103242443..103281334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006498705.3XP_006498768.1  ETS-related transcription factor Elf-5 isoform X1

      See identical proteins and their annotated locations for XP_006498768.1

      UniProtKB/Swiss-Prot
      Q8VDK3, Q921H5, Q9Z2K6
      UniProtKB/TrEMBL
      Q3ULZ4, Q3V1F7
      Conserved Domains (2) summary
      cd08538
      Location:39122
      SAM_PNT-ESE-2-like; Sterile alpha motif (SAM)/Pointed domain of ESE-2 like ETS transcriptional regulators
      smart00413
      Location:162246
      ETS; erythroblast transformation specific domain