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    Tfdp1 transcription factor Dp 1 [ Mus musculus (house mouse) ]

    Gene ID: 21781, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Tfdp1provided by MGI
    Official Full Name
    transcription factor Dp 1provided by MGI
    Primary source
    MGI:MGI:101934
    See related
    Ensembl:ENSMUSG00000038482 AllianceGenome:MGI:101934
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dp1; Drtf1
    Summary
    Enables DNA-binding transcription factor activity and cis-regulatory region sequence-specific DNA binding activity. Involved in negative regulation of fat cell proliferation. Acts upstream of or within anoikis; epidermis development; and regulation of nucleobase-containing compound metabolic process. Located in cytoplasm and nucleus. Part of transcription regulator complex. Is expressed in several structures, including alimentary system; central nervous system; early conceptus; genitourinary system; and retina. Human ortholog(s) of this gene implicated in mismatch repair cancer syndrome. Orthologous to several human genes including TFDP1 (transcription factor Dp-1). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in CNS E11.5 (RPKM 53.8), liver E14 (RPKM 51.3) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Tfdp1 in Genome Data Viewer
    Location:
    8 A1.1; 8 5.78 cM
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (13388273..13428448)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (13338725..13378448)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene defective in cullin neddylation 1 domain containing 2 Neighboring gene predicted gene, 25014 Neighboring gene transmembrane and coiled-coil domains 3 Neighboring gene STARR-positive B cell enhancer ABC_E6621 Neighboring gene ATPase, H+/K+ exchanging, beta polypeptide Neighboring gene G protein-coupled receptor kinase 1

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Loss of protein phosphatase 2A expression correlates with phosphorylation of DP-1 and reversal of dysplasia through differentiation in a conditional mouse model of cancer progression. Tilli MT, et al. Cancer Res, 2003 Nov 15. PMID 14633688
    2. Deregulated expression of DP1 induces epidermal proliferation and enhances skin carcinogenesis. Wang D, et al. Mol Carcinog, 2001 Jun. PMID 11429786
    3. A new component of the transcription factor DRTF1/E2F. Girling R, et al. Nature, 1993 Mar 4. PMID 8446173
    4. Modulation of E2F activity is linked to interferon-induced growth suppression of hematopoietic cells. Iwase S, et al. J Biol Chem, 1997 May 9. PMID 9139687
    5. In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis. Tran NT, et al. Leukemia, 2024 Sep. PMID 39043964, Free PMC Article

    See all (69) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
      Title: In vivo CRISPR/Cas9-mediated screen reveals a critical function of TFDP1 and E2F4 transcription factors in hematopoiesis.
    2. Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.
      Title: Transcription factor Dp-1 knockdown downregulates thymidine kinase 1 expression to protect against proliferation and epithelial-mesenchymal transition in cervical cancer.
    3. KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.
      Title: KDM6B interacts with TFDP1 to activate P53 signaling in regulating mouse palatogenesis.
    4. Kbtbd5 regulates skeletal muscle myogenesis through the regulation of E2F1-DP1 activity
      Title: Kelch Repeat and BTB Domain Containing Protein 5 (Kbtbd5) Regulates Skeletal Muscle Myogenesis through the E2F1-DP1 Complex.
    5. Cell cycle suppression by Cdk5 is made through the formation of a previously unknown complex consisting of the p35-Cdk5 dimer and E2F1, which excludes the E2F1 cofactor, DP1, thus inhibiting E2F1 binding to the promoters of various cell cycle genes.
      Title: Cdk5 suppresses the neuronal cell cycle by disrupting the E2F1-DP1 complex.
    6. Persistent PP2A expression prevented the appearance of the phosphorylated form of DP-1 required for cellular differentiation and reversal of dysplasia after loss of oncogene expression.
      Title: Loss of protein phosphatase 2A expression correlates with phosphorylation of DP-1 and reversal of dysplasia through differentiation in a conditional mouse model of cancer progression.
    7. Results show that Dp1 is largely dispensable for embryonic development, despite the absolute extraembryonic requirement for Dp1.
      Title: Dp1 is largely dispensable for embryonic development.
    8. Absolutely required for extra-embryonic development and consequently embryonic survival.
      Title: Dp1 is required for extra-embryonic development.
    Submit: New GeneRIF Correction

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (1) 
    • Targeted (1)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to DNA-binding transcription activator activity, RNA polymerase II-specific ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables DNA-binding transcription factor binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    contributes_to RNA polymerase II transcription regulatory region sequence-specific DNA binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables RNA polymerase II-specific DNA-binding transcription factor binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein domain specific binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables transcription regulator inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within anoikis IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within epidermis development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of fat cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of G1/S transition of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of RNA polymerase II transcription regulator complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Rb-E2F complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Rb-E2F complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    transcription factor Dp-1
    Names
    DRTF1-polypeptide 1
    E2F dimerization partner 1
    cell cycle regulatory transcription factor DP1

    NCBI Reference Sequences (RefSeq)

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    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001291765.2 → NP_001278694.1  transcription factor Dp-1 isoform 1

      See identical proteins and their annotated locations for NP_001278694.1

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Consensus CDS
      CCDS22110.1
      UniProtKB/Swiss-Prot
      Q08639
      UniProtKB/TrEMBL
      Q3V3X3, Q9D297
      Related
      ENSMUSP00000147881.2, ENSMUST00000209885.2
      Conserved Domains (3) summary
      cd14458
      Location:198 → 244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:112 → 193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200 → 338
      DP; Transcription factor DP

    2. NM_001291766.2 → NP_001278695.1  transcription factor Dp-1 isoform 2

      See identical proteins and their annotated locations for NP_001278695.1

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Consensus CDS
      CCDS85506.1
      UniProtKB/TrEMBL
      Q9CYZ7
      Conserved Domains (3) summary
      cd14458
      Location:78 → 124
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:1 → 73
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:80 → 218
      DP; Transcription factor DP

    3. NM_001291768.2 → NP_001278697.1  transcription factor Dp-1 isoform 2

      See identical proteins and their annotated locations for NP_001278697.1

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Consensus CDS
      CCDS85506.1
      UniProtKB/TrEMBL
      Q9CYZ7
      Related
      ENSMUSP00000147662.2, ENSMUST00000209396.2
      Conserved Domains (3) summary
      cd14458
      Location:78 → 124
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:1 → 73
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:80 → 218
      DP; Transcription factor DP

    4. NM_001358991.2 → NP_001345920.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Consensus CDS
      CCDS85506.1
      UniProtKB/TrEMBL
      Q9CYZ7
      Conserved Domains (3) summary
      cd14458
      Location:78 → 124
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:1 → 73
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:80 → 218
      DP; Transcription factor DP

    5. NM_001413797.1 → NP_001400726.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    6. NM_001413798.1 → NP_001400727.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    7. NM_001413799.1 → NP_001400728.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    8. NM_001413800.1 → NP_001400729.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    9. NM_001413801.1 → NP_001400730.1  transcription factor Dp-1 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC130818

    10. NM_001413802.1 → NP_001400731.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    11. NM_001413803.1 → NP_001400732.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    12. NM_001413804.1 → NP_001400733.1  transcription factor Dp-1 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AC130818

    13. NM_001413805.1 → NP_001400734.1  transcription factor Dp-1 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AC130818

    14. NM_001413806.1 → NP_001400735.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    15. NM_001413807.1 → NP_001400736.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    16. NM_001413808.1 → NP_001400737.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    17. NM_001413809.1 → NP_001400738.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    18. NM_001413810.1 → NP_001400739.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    19. NM_001413811.1 → NP_001400740.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    20. NM_001413812.1 → NP_001400741.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    21. NM_001413813.1 → NP_001400742.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    22. NM_001413814.1 → NP_001400743.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    23. NM_001413815.1 → NP_001400744.1  transcription factor Dp-1 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AC130818

    24. NM_001413816.1 → NP_001400745.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    25. NM_001413817.1 → NP_001400746.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    26. NM_001413818.1 → NP_001400747.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    27. NM_001413819.1 → NP_001400748.1  transcription factor Dp-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/Swiss-Prot
      Q08639
      UniProtKB/TrEMBL
      Q3V3X3

    28. NM_001413820.1 → NP_001400749.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    29. NM_001413821.1 → NP_001400750.1  transcription factor Dp-1 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/TrEMBL
      Q9CYZ7

    30. NM_001413822.1 → NP_001400751.1  transcription factor Dp-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/Swiss-Prot
      Q08639
      UniProtKB/TrEMBL
      Q3V3X3

    31. NM_001413823.1 → NP_001400752.1  transcription factor Dp-1 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC130818
      UniProtKB/Swiss-Prot
      Q08639
      UniProtKB/TrEMBL
      Q3V3X3

    32. NM_009361.4 → NP_033387.1  transcription factor Dp-1 isoform 1

      See identical proteins and their annotated locations for NP_033387.1

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Consensus CDS
      CCDS22110.1
      UniProtKB/Swiss-Prot
      Q08639
      UniProtKB/TrEMBL
      Q3V3X3, Q9D297
      Related
      ENSMUST00000211606.2
      Conserved Domains (3) summary
      cd14458
      Location:198 → 244
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:112 → 193
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:200 → 338
      DP; Transcription factor DP

    RNA

    1. NR_182219.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130818

    2. NR_182220.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      AC130818
      Related
      ENSMUST00000210501.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      13388273..13428448
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017312657.3 → XP_017168146.1  transcription factor Dp-1 isoform X1

      UniProtKB/TrEMBL
      Q9D297
      Conserved Domains (3) summary
      cd14458
      Location:200 → 246
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:115 → 195
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:202 → 340
      DP; Transcription factor DP

    2. XM_036153872.1 → XP_036009765.1  transcription factor Dp-1 isoform X1

      UniProtKB/TrEMBL
      Q9D297
      Conserved Domains (3) summary
      cd14458
      Location:200 → 246
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:115 → 195
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:202 → 340
      DP; Transcription factor DP

    3. XM_017312659.3 → XP_017168148.1  transcription factor Dp-1 isoform X1

      UniProtKB/TrEMBL
      Q9D297
      Conserved Domains (3) summary
      cd14458
      Location:200 → 246
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:115 → 195
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:202 → 340
      DP; Transcription factor DP

    4. XM_036153874.1 → XP_036009767.1  transcription factor Dp-1 isoform X3

      UniProtKB/TrEMBL
      Q9CYZ7
      Conserved Domains (3) summary
      cd14458
      Location:78 → 124
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:1 → 73
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:80 → 218
      DP; Transcription factor DP

    5. XM_017312658.3 → XP_017168147.1  transcription factor Dp-1 isoform X1

      UniProtKB/TrEMBL
      Q9D297
      Conserved Domains (3) summary
      cd14458
      Location:200 → 246
      DP_DD; coiled coil [structural motif]
      pfam02319
      Location:115 → 195
      E2F_TDP; E2F/DP family winged-helix DNA-binding domain
      pfam08781
      Location:202 → 340
      DP; Transcription factor DP
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q08639.1 GenPept UniProtKB/Swiss-Prot:Q08639

    Gene LinkOut

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