C2cd2l C2 calcium-dependent domain containing 2-like [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: C2cd2lprovided by MGI
Official Full Name: C2 calcium-dependent domain containing 2-likeprovided by MGI
Primary source: MGI:MGI:1919014
See related: Ensembl:ENSMUSG00000032120 AllianceGenome:MGI:1919014
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Tmem24; 1300006O23Rik
Summary: Enables insulin binding activity. Acts upstream of or within positive regulation of insulin secretion involved in cellular response to glucose stimulus. Located in membrane. Is expressed in jaw bone; nervous system; neural retina; and thoracic segment skeleton. Orthologous to human C2CD2L (C2CD2 like). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in duodenum adult (RPKM 47.0), small intestine adult (RPKM 38.3) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 9 A5.2; 9 24.84 cM

Exon count:: 14

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	9	NC_000075.7 (44220534..44231579, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	9	NC_000075.6 (44309237..44320282, complement)

Chromosome 9 - NC_000075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Protein expression level differences of C2CD2L, DIRAS2, and PYCR2 in prefrontal neocortex of male M. fascicularis cases discriminates between those with heavy or light voluntary alcohol consumption. Results for C2CD2L were corroborated in chronic intermittent ethanol treated BXD strains of mice, in which the D allele (DBA/2) is associated with lower alcohol consumption than the B allele (C57BL/6J).
Title: Orbitofrontal Neuroadaptations and Cross-Species Synaptic Biomarkers in Heavy-Drinking Macaques.
The identification of TMEM24 in the context of a comprehensive set of sequential insulin-binding partners provides a molecular description of the insulin secretory pathway in beta cells.
Title: Insulin biosynthetic interaction network component, TMEM24, facilitates insulin reserve pool release.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables insulin binding	IDA Inferred from Direct Assay more info	PubMed
enables phosphatidylinositol binding	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol binding	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol binding	ISS Inferred from Sequence or Structural Similarity more info
enables phosphatidylinositol transfer activity	IBA Inferred from Biological aspect of Ancestor more info
enables phosphatidylinositol transfer activity	ISO Inferred from Sequence Orthology more info
enables phosphatidylinositol transfer activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in intermembrane lipid transfer	IEA Inferred from Electronic Annotation more info
involved_in phospholipid transport	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of insulin secretion involved in cellular response to glucose stimulus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of insulin secretion involved in cellular response to glucose stimulus	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
located_in cortical endoplasmic reticulum	ISO Inferred from Sequence Orthology more info
located_in cortical endoplasmic reticulum	ISS Inferred from Sequence or Structural Similarity more info
colocalizes_with cytoplasmic side of apical plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
colocalizes_with cytoplasmic side of apical plasma membrane	ISO Inferred from Sequence Orthology more info
colocalizes_with cytoplasmic side of apical plasma membrane	ISS Inferred from Sequence or Structural Similarity more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info
located_in endoplasmic reticulum-plasma membrane contact site	ISO Inferred from Sequence Orthology more info
located_in endoplasmic reticulum-plasma membrane contact site	ISS Inferred from Sequence or Structural Similarity more info
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: phospholipid transfer protein C2CD2L

Names: C2 domain-containing protein 2-like; transmembrane protein 24

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001359259.2 → NP_001346188.1 phospholipid transfer protein C2CD2L isoform 2

Status: VALIDATED

Source sequence(s)

AC124577

UniProtKB/TrEMBL

Q3U590

Conserved Domains (1) summary

cl14603
Location:288 → 412

C2; C2 domain
NM_001433213.1 → NP_001420142.1 phospholipid transfer protein C2CD2L isoform 3

Status: VALIDATED

Source sequence(s)

AC124577
NM_001433214.1 → NP_001420143.1 phospholipid transfer protein C2CD2L isoform 4

Status: VALIDATED

Source sequence(s)

AC124577
NM_001433215.1 → NP_001420144.1 phospholipid transfer protein C2CD2L isoform 5

Status: VALIDATED

Source sequence(s)

AC124577

UniProtKB/TrEMBL

Q8CAA2
NM_001433216.1 → NP_001420145.1 phospholipid transfer protein C2CD2L isoform 6

Status: VALIDATED

Source sequence(s)

AC124577
NM_001433218.1 → NP_001420147.1 phospholipid transfer protein C2CD2L isoform 7

Status: VALIDATED

Source sequence(s)

AC124577
NM_001433219.1 → NP_001420148.1 phospholipid transfer protein C2CD2L isoform 8

Status: VALIDATED

Source sequence(s)

AC124577
NM_027909.3 → NP_082185.2 phospholipid transfer protein C2CD2L isoform 1

See identical proteins and their annotated locations for NP_082185.2

Status: VALIDATED

Source sequence(s)

AC124577

Consensus CDS

CCDS23103.1

UniProtKB/Swiss-Prot

G5E8D9, Q80X80

UniProtKB/TrEMBL

Q3U590

Related

ENSMUSP00000065233.9, ENSMUST00000065080.10

Conserved Domains (1) summary

cl14603
Location:288 → 412

C2; C2 domain