Cacna1i calcium channel, voltage-dependent, alpha 1I subunit [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cacna1iprovided by MGI
Official Full Name: calcium channel, voltage-dependent, alpha 1I subunitprovided by MGI
Primary source: MGI:MGI:2178051
See related: Ensembl:ENSMUSG00000022416 AllianceGenome:MGI:2178051
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Ca(V)3.3
Summary: Predicted to enable low voltage-gated calcium channel activity and voltage-gated sodium channel activity. Acts upstream of or within neuronal action potential and sleep. Predicted to be part of voltage-gated sodium channel complex. Predicted to be active in neuron projection. Is expressed in brain. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human CACNA1I (calcium voltage-gated channel subunit alpha1 I). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in spleen adult (RPKM 8.3), frontal lobe adult (RPKM 8.1) and 8 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.85 cM

Exon count:: 37

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (80171439..80282493)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (80287238..80398292)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Trigeminal neuropathic pain is alleviated by inhibition of Cav3.3 T-type calcium channels in mice.
Title: Trigeminal neuropathic pain is alleviated by inhibition of Ca(v)3.3 T-type calcium channels in mice.
Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.
Title: Homeostatic plasticity and burst activity are mediated by hyperpolarization-activated cation currents and T-type calcium channels in neuronal cultures.
Membrane-protein extraction and use of an intracellular protein-transport inhibitor showed that GDF-15 promoted CaV3.1 and CaV3.3 alpha-subunit expression by trafficking to the membrane.
Title: Growth differentiation factor-15 promotes glutamate release in medial prefrontal cortex of mice through upregulation of T-type calcium channels.
Extracellular pressure increases [Ca(2+)]i via Cav3.3, driving a PKC-beta- IKK- IkB-NF-kB pathway that stimulates cancer cell proliferation
Title: Increased extracellular pressure stimulates tumor proliferation by a mechanosensitive calcium channel and PKC-β.
using Ca(V)3.3(-/-) mice we found that Ca(V)3.3 channels trigger synaptic plasticity in reticular thalamic neurons
Title: Synaptic plasticity at intrathalamic connections via CaV3.3 T-type Ca2+ channels and GluN2B-containing NMDA receptors.
data identify a central role for Ca(V)3.3 channels in the rhythmogenic properties of the sleep-spindle generator and provide a molecular target to elucidate the roles of sleep spindles for brain function and development.
Title: The Ca(V)3.3 calcium channel is the major sleep spindle pacemaker in thalamus.
A T-type calcium channel required for normal function of a mammalian mechanoreceptor.
Title: A T-type calcium channel required for normal function of a mammalian mechanoreceptor.
Expression of T-type calcium channels increases during perinatal development in various brain regions and in the spinal cord.
Title: Immunological characterization of T-type voltage-dependent calcium channel CaV3.1 (alpha 1G) and CaV3.3 (alpha 1I) isoforms reveal differences in their localization, expression, and neural development.
alpha1(G) T-type calcium channels contribute to sleep waves as well as to behavioral state of sleep.
Title: T-type calcium channels and thalamocortical rhythms in sleep: a perspective from studies of T-type calcium channel knockout mice.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (6) 1 citation
Targeted (4) 1 citation

General gene information

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Markers

Cacna1i (e-PCR), detects polymorphism
- UniSTS:463445

D7Hmgc1 (e-PCR)
- UniSTS:260813

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables low voltage-gated calcium channel activity	IBA Inferred from Biological aspect of Ancestor more info
enables low voltage-gated calcium channel activity	ISO Inferred from Sequence Orthology more info
enables voltage-gated sodium channel activity	IBA Inferred from Biological aspect of Ancestor more info

Process	Evidence Code	Pubs
involved_in calcium ion import	IBA Inferred from Biological aspect of Ancestor more info
involved_in calcium ion import	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within calcium ion transport	ISO Inferred from Sequence Orthology more info
involved_in calcium ion transport into cytosol	ISO Inferred from Sequence Orthology more info
involved_in membrane depolarization during action potential	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within neuronal action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of calcium ion-dependent exocytosis	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within regulation of membrane potential	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sleep	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in neuron projection	IBA Inferred from Biological aspect of Ancestor more info
part_of voltage-gated sodium channel complex	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: voltage-dependent T-type calcium channel subunit alpha-1I

Names: low voltage-activated T-type calcium channel alpha-1 subunit (CACNA1I); low-voltage-activated calcium channel alpha13.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001044308.2 → NP_001037773.2 voltage-dependent T-type calcium channel subunit alpha-1I

Status: VALIDATED

Source sequence(s)

AC155313, AK147585, CJ259561

Consensus CDS

CCDS49670.1

UniProtKB/TrEMBL

E0CXK2, E9Q7P2

Related

ENSMUSP00000125063.2, ENSMUST00000160424.8

Conserved Domains (1) summary

pfam00520
Location:615 → 824

Ion_trans; Ion transport protein

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

80171439..80282493

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006520949.2 → XP_006521012.1 voltage-dependent T-type calcium channel subunit alpha-1I isoform X1

UniProtKB/TrEMBL

E0CXK2

Conserved Domains (2) summary

PHA03307
Location:1867 → 2226

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:597 → 824

Ion_trans; Ion transport protein
XM_006520950.3 → XP_006521013.1 voltage-dependent T-type calcium channel subunit alpha-1I isoform X2

UniProtKB/TrEMBL

E0CXK2

Conserved Domains (2) summary

PHA03307
Location:1854 → 2213

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:597 → 824

Ion_trans; Ion transport protein
XM_030248558.2 → XP_030104418.1 voltage-dependent T-type calcium channel subunit alpha-1I isoform X3

UniProtKB/TrEMBL

E0CXK2

Conserved Domains (2) summary

PHA03307
Location:1827 → 2186

PHA03307; transcriptional regulator ICP4; Provisional

pfam00520
Location:597 → 824

Ion_trans; Ion transport protein