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    Cd59b CD59b antigen [ Mus musculus (house mouse) ]

    Gene ID: 333883, updated on 9-Dec-2024

    Summary

    Official Symbol
    Cd59bprovided by MGI
    Official Full Name
    CD59b antigenprovided by MGI
    Primary source
    MGI:MGI:1888996
    See related
    Ensembl:ENSMUSG00000068686 AllianceGenome:MGI:1888996
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable complement binding activity. Acts upstream of or within negative regulation of activation of membrane attack complex. Located in cell surface and plasma membrane. Is expressed in blood; heart; liver; lung; and testis. Human ortholog(s) of this gene implicated in colorectal carcinoma and ovarian cancer. Orthologous to human CD59 (CD59 molecule (CD59 blood group)). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 6.6), subcutaneous fat pad adult (RPKM 5.9) and 24 other tissues See more
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    Genomic context

    See Cd59b in Genome Data Viewer
    Location:
    2 E2; 2 54.51 cM
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103900127..103920619)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (104069781..104085790)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931422A03 gene Neighboring gene STARR-seq mESC enhancer starr_05277 Neighboring gene STARR-positive B cell enhancer ABC_E5954 Neighboring gene STARR-seq mESC enhancer starr_05279 Neighboring gene F-box protein 3 Neighboring gene predicted gene, 24644 Neighboring gene STARR-seq mESC enhancer starr_05280 Neighboring gene CD59a antigen Neighboring gene RIKEN cDNA A930018P22 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Targeted (1)  1 citation

    Pathways from PubChem

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables complement binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables complement binding ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cell surface IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cell surface ISO
    Inferred from Sequence Orthology
    more info
     
    located_in compact myelin ISO
    Inferred from Sequence Orthology
    more info
     
    located_in external side of plasma membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcolemma ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    CD59B glycoprotein
    Names
    MAC-IP
    MAC-inhibitory protein
    MACIF
    membrane attack complex inhibition factor
    protectin

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001368215.1NP_001355144.1  CD59B glycoprotein precursor

      Status: VALIDATED

      Source sequence(s)
      BX640578, BX813317
      Consensus CDS
      CCDS16486.1
      UniProtKB/Swiss-Prot
      P58019, Q920G7
      Related
      ENSMUSP00000106760.3, ENSMUST00000111130.3
      Conserved Domains (1) summary
      cd00117
      Location:2495
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    2. NM_181858.2NP_862906.1  CD59B glycoprotein precursor

      See identical proteins and their annotated locations for NP_862906.1

      Status: VALIDATED

      Source sequence(s)
      BX640578, BX813317
      Consensus CDS
      CCDS16486.1
      UniProtKB/Swiss-Prot
      P58019, Q920G7
      Related
      ENSMUSP00000087912.2, ENSMUST00000090429.8
      Conserved Domains (1) summary
      cd00117
      Location:2495
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      103900127..103920619
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006499802.5XP_006499865.1  CD59B glycoprotein isoform X4

      See identical proteins and their annotated locations for XP_006499865.1

      UniProtKB/Swiss-Prot
      P58019, Q920G7
      Related
      ENSMUSP00000117553.2, ENSMUST00000129749.9
      Conserved Domains (1) summary
      cd00117
      Location:2495
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    2. XM_006499805.2XP_006499868.1  CD59B glycoprotein isoform X4

      See identical proteins and their annotated locations for XP_006499868.1

      UniProtKB/Swiss-Prot
      P58019, Q920G7
      Conserved Domains (1) summary
      cd00117
      Location:2495
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    3. XM_006499801.3XP_006499864.1  CD59B glycoprotein isoform X2

      Conserved Domains (1) summary
      cd00117
      Location:54125
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    4. XM_017319062.1XP_017174551.1  CD59B glycoprotein isoform X1

      Conserved Domains (1) summary
      cd00117
      Location:67138
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    5. XM_036162337.1XP_036018230.1  CD59B glycoprotein isoform X3

      Conserved Domains (1) summary
      cl10471
      Location:6799
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...
    6. XM_006499803.4XP_006499866.1  CD59B glycoprotein isoform X4

      See identical proteins and their annotated locations for XP_006499866.1

      UniProtKB/Swiss-Prot
      P58019, Q920G7
      Conserved Domains (1) summary
      cd00117
      Location:2495
      LU; Ly-6 antigen / uPA receptor -like domain; occurs singly in GPI-linked cell-surface glycoproteins (Ly-6 family,CD59, thymocyte B cell antigen, Sgp-2) or as three-fold repeated domain in urokinase-type plasminogen activator receptor. Topology of these ...