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    Cabin1 calcineurin binding protein 1 [ Mus musculus (house mouse) ]

    Gene ID: 104248, updated on 4-Jan-2025

    Summary

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    Official Symbol
    Cabin1provided by MGI
    Official Full Name
    calcineurin binding protein 1provided by MGI
    Primary source
    MGI:MGI:1298375
    See related
    Ensembl:ENSMUSG00000020196 AllianceGenome:MGI:1298375
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Cain; Ppp3in; A330070M20Rik
    Summary
    Predicted to enable protein domain specific binding activity; protein phosphatase 2B binding activity; and protein phosphatase inhibitor activity. Predicted to contribute to nucleosome binding activity. Predicted to be involved in negative regulation of apoptotic process. Predicted to act upstream of or within signal transduction. Predicted to be located in aggresome; cytosol; and nucleoplasm. Predicted to be active in nucleus. Is expressed in heart. Human ortholog(s) of this gene implicated in ovarian carcinoma. Orthologous to human CABIN1 (calcineurin binding protein 1). [provided by Alliance of Genome Resources, Jan 2025]
    Expression
    Ubiquitous expression in thymus adult (RPKM 14.2), ovary adult (RPKM 14.2) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cabin1 in Genome Data Viewer
    Location:
    10 C1; 10 38.56 cM
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 10 NC_000076.7 (75481944..75600194, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 10 NC_000076.6 (75646110..75764357, complement)

    Chromosome 10 - NC_000076.7Genomic Context describing neighboring genes Neighboring gene predicted gene, 19688 Neighboring gene STARR-seq mESC enhancer starr_27156 Neighboring gene sushi domain containing 2 Neighboring gene predicted gene, 40696 Neighboring gene STARR-positive B cell enhancer mm9_chr10:75226990-75227291 Neighboring gene STARR-positive B cell enhancer ABC_E9346 Neighboring gene cytochrome b-c1 complex subunit 7 pseudogene Neighboring gene D-dopachrome tautomerase

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Calpain-dependent cleavage of cain/cabin1 activates calcineurin to mediate calcium-triggered cell death. Kim MJ, et al. Proc Natl Acad Sci U S A, 2002 Jul 23. PMID 12114545, Free PMC Article
    2. The Impact of Electrographic Seizures on Developing Hippocampal Dendrites Is Calcineurin Dependent. Nishimura M, et al. eNeuro, 2017 Mar-Apr. PMID 28462391, Free PMC Article
    3. HIRA contributes to zygote formation in mice and is implicated in human 1PN zygote phenotype. Smith R, et al. Reproduction, 2021 May 10. PMID 33835048, Free PMC Article
    4. Calcineurin inhibitor protein (CAIN) attenuates Group I metabotropic glutamate receptor endocytosis and signaling. Ferreira LT, et al. J Biol Chem, 2009 Oct 16. PMID 19717561, Free PMC Article
    5. Cabin1 restrains p53 activity on chromatin. Jang H, et al. Nat Struct Mol Biol, 2009 Sep. PMID 19668210

    See all (37) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (4) 
    • Targeted (3)  1 citation

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    contributes_to nucleosome binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein domain specific binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase 2B binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein phosphatase inhibitor activity ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    acts_upstream_of_or_within signal transduction TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in aggresome ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    calcineurin-binding protein cabin-1
    Names
    calcineurin inhibitor
    protein phosphatase 3 inhibitor

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_172549.3 → NP_766137.2  calcineurin-binding protein cabin-1

      Status: VALIDATED

      Source sequence(s)
      AK039606, BC051668, BC057551, BQ714836, BU705499, CN722898, CV884170
      Consensus CDS
      CCDS35938.1
      UniProtKB/TrEMBL
      B9EKC5, G3X8Q1
      Related
      ENSMUSP00000001712.7, ENSMUST00000001712.8
      Conserved Domains (4) summary
      PHA03247
      Location:1915 → 2161
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2123 → 2157
      MEF2_binding; MEF2 binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000076.7 Reference GRCm39 C57BL/6J

      Range
      75481944..75600194 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006513020.5 → XP_006513083.1  calcineurin-binding protein cabin-1 isoform X2

      UniProtKB/TrEMBL
      B9EKC5
      Conserved Domains (4) summary
      PHA03247
      Location:1886 → 2132
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2094 → 2128
      MEF2_binding; MEF2 binding

    2. XM_006513019.5 → XP_006513082.1  calcineurin-binding protein cabin-1 isoform X1

      UniProtKB/TrEMBL
      B9EKC5, G3X8Q1
      Conserved Domains (4) summary
      PHA03247
      Location:1915 → 2161
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:34 → 210
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:90 → 118
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:2123 → 2157
      MEF2_binding; MEF2 binding

    3. XM_006513021.3 → XP_006513084.1  calcineurin-binding protein cabin-1 isoform X3

      Conserved Domains (3) summary
      sd00006
      Location:191 → 218
      TPR; TPR repeat [structural motif]
      pfam09047
      Location:1258 → 1292
      MEF2_binding; MEF2 binding
      pfam15058
      Location:1111 → 1258
      Speriolin_N; Speriolin N-terminus

    4. XM_006513022.3 → XP_006513085.1  calcineurin-binding protein cabin-1 isoform X4

      Conserved Domains (2) summary
      pfam09047
      Location:1045 → 1079
      MEF2_binding; MEF2 binding
      pfam15058
      Location:898 → 1045
      Speriolin_N; Speriolin N-terminus

    RNA

    1. XR_001779404.2 RNA Sequence

    2. XR_001779405.3 RNA Sequence

    3. XR_380334.5 RNA Sequence

    4. XR_001779406.3 RNA Sequence

    Nucleotide Protein Strain
    Heading Accession and Version

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