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    Cep170b centrosomal protein 170B [ Mus musculus (house mouse) ]

    Gene ID: 217882, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Cep170bprovided by MGI
    Official Full Name
    centrosomal protein 170Bprovided by MGI
    Primary source
    MGI:MGI:2145043
    See related
    Ensembl:ENSMUSG00000072825 AllianceGenome:MGI:2145043
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Kiaa0284; mKIAA0284
    Summary
    Predicted to be located in cytoplasm and microtubule. Is expressed in several structures, including alimentary system; brain; respiratory system; sensory organ; and urinary system. Orthologous to human CEP170B (centrosomal protein 170B). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Ubiquitous expression in colon adult (RPKM 47.7), ovary adult (RPKM 28.6) and 26 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Cep170b in Genome Data Viewer
    Location:
    12 F1; 12 61.2 cM
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 12 NC_000078.7 (112687950..112713026)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 12 NC_000078.6 (112721514..112746592)

    Chromosome 12 - NC_000078.7Genomic Context describing neighboring genes Neighboring gene zinc finger and BTB domain containing 42 Neighboring gene predicted gene, 30298 Neighboring gene predicted gene, 30238 Neighboring gene predicted gene, 46382 Neighboring gene microRNA 6940 Neighboring gene transmembrane protein 11 pseudogene Neighboring gene STARR-positive B cell enhancer ABC_E5361 Neighboring gene phospholipase D family member 4

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. An integrated genetic, radiation hybrid, physical and transcription map of a region of distal mouse chromosome 12, including an imprinted locus and the 'Legs at odd angles' (Loa) mutation. Witherden AS, et al. Gene, 2002 Jan 23. PMID 11867214
    2. Identification of kidney mesenchymal genes by a combination of microarray analysis and Sall1-GFP knockin mice. Takasato M, et al. Mech Dev, 2004 Jun. PMID 15172686
    3. Decreased Anxiety-Related Behaviour but Apparently Unperturbed NUMB Function in Ligand of NUMB Protein-X (LNX) 1/2 Double Knockout Mice. Lenihan JA, et al. Mol Neurobiol, 2017 Dec. PMID 27889896
    4. The TRIM9/TRIM67 neuronal interactome reveals novel activators of morphogenesis. Menon S, et al. Mol Biol Cell, 2021 Feb 15. PMID 33378226, Free PMC Article
    5. Comprehensive identification of phosphorylation sites in postsynaptic density preparations. Trinidad JC, et al. Mol Cell Proteomics, 2006 May. PMID 16452087

    See all (28) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in microtubule IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    centrosomal protein of 170 kDa protein B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024602.4 → NP_001019773.2  centrosomal protein of 170 kDa protein B isoform 1

      See identical proteins and their annotated locations for NP_001019773.2

      Status: VALIDATED

      Source sequence(s)
      AK147410, AK147612, CJ125191
      Consensus CDS
      CCDS56867.1
      UniProtKB/Swiss-Prot
      Q3UH33, Q3UHG1, Q80U49, Q80UM2
      Related
      ENSMUSP00000098580.4, ENSMUST00000101018.11
      Conserved Domains (2) summary
      pfam00498
      Location:23 → 89
      FHA; FHA domain
      pfam15308
      Location:832 → 1510
      CEP170_C; CEP170 C-terminus

    2. NM_001412902.1 → NP_001399831.1  centrosomal protein of 170 kDa protein B isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC124353
      UniProtKB/TrEMBL
      B9EIX2
      Related
      ENSMUSP00000152143.2, ENSMUST00000220627.2

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000078.7 Reference GRCm39 C57BL/6J

      Range
      112687950..112713026
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006515766.5 → XP_006515829.1  centrosomal protein of 170 kDa protein B isoform X1

      See identical proteins and their annotated locations for XP_006515829.1

      UniProtKB/Swiss-Prot
      Q3UH33, Q3UHG1, Q80U49, Q80UM2
      Conserved Domains (2) summary
      pfam00498
      Location:23 → 89
      FHA; FHA domain
      pfam15308
      Location:832 → 1510
      CEP170_C; CEP170 C-terminus
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q80U49.2 GenPept UniProtKB/Swiss-Prot:Q80U49

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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