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    Nat10 N-acetyltransferase 10 [ Mus musculus (house mouse) ]

    Gene ID: 98956, updated on 9-Dec-2024

    Summary

    Official Symbol
    Nat10provided by MGI
    Official Full Name
    N-acetyltransferase 10provided by MGI
    Primary source
    MGI:MGI:2138939
    See related
    Ensembl:ENSMUSG00000027185 AllianceGenome:MGI:2138939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Summary
    Predicted to enable DNA polymerase binding activity; N-acetyltransferase activity; and tRNA binding activity. Predicted to be involved in several processes, including rRNA acetylation involved in maturation of SSU-rRNA; regulation of centrosome duplication; and regulation of macromolecule biosynthetic process. Predicted to be located in midbody. Predicted to be part of small-subunit processome and telomerase holoenzyme complex. Predicted to be active in nucleolus. Is expressed in several structures, including alimentary system; clavicle; cranium bone primordium; early conceptus; and skeletal musculature. Orthologous to human NAT10 (N-acetyltransferase 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 9.4), CNS E11.5 (RPKM 8.6) and 28 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Nat10 in Genome Data Viewer
    Location:
    2 E2; 2 54.43 cM
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (103551603..103593292, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (103721258..103762954, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene STARR-seq mESC enhancer starr_05270 Neighboring gene STARR-positive B cell enhancer ABC_E811 Neighboring gene catalase Neighboring gene RIKEN cDNA 8030431J09 gene Neighboring gene STARR-positive B cell enhancer ABC_E7843 Neighboring gene STARR-positive B cell enhancer ABC_E812 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103408122-103408323 Neighboring gene ankyrin repeat and BTB domain containing 2 Neighboring gene VISTA enhancer mm1312 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103502331-103502560 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103522571-103522790 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:103543647-103543756 Neighboring gene STARR-positive B cell enhancer ABC_E11149 Neighboring gene STARR-positive B cell enhancer ABC_E4483 Neighboring gene STARR-positive B cell enhancer mm9_chr2:103625945-103626245 Neighboring gene cell cycle associated protein 1 Neighboring gene STARR-seq mESC enhancer starr_05272 Neighboring gene STARR-seq mESC enhancer starr_05273 Neighboring gene RIKEN cDNA 4930547E08 gene Neighboring gene predicted gene 13880

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6) 
    • Targeted (1) 

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC25461

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA polymerase binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA polymerase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA N-acetyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables mRNA N-acetyltransferase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables rRNA cytidine N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tRNA N-acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables tRNA N-acetyltransferase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in negative regulation of telomere maintenance via telomerase IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of telomere maintenance via telomerase ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in positive regulation of translation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein acetylation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein acetylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in rRNA acetylation involved in maturation of SSU-rRNA IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in rRNA acetylation involved in maturation of SSU-rRNA IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of centrosome duplication ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of centrosome duplication ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of translation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ribosomal small subunit biogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in tRNA acetylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in tRNA acetylation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in tRNA wobble cytosine modification IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in midbody IEA
    Inferred from Electronic Annotation
    more info
     
    located_in midbody ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleolus IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISO
    Inferred from Sequence Orthology
    more info
     
    part_of small-subunit processome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of telomerase holoenzyme complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of telomerase holoenzyme complex ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    RNA cytidine acetyltransferase
    Names
    18S rRNA cytosine acetyltransferase
    novel putative ATPase domain containing protein
    NP_001411642.1
    NP_694766.1
    XP_006500518.1
    XP_036018634.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001424713.1NP_001411642.1  RNA cytidine acetyltransferase isoform 2

      Status: VALIDATED

      Source sequence(s)
      BX537331
    2. NM_153126.4NP_694766.1  RNA cytidine acetyltransferase

      See identical proteins and their annotated locations for NP_694766.1

      Status: VALIDATED

      Source sequence(s)
      BX537331
      Consensus CDS
      CCDS16480.1
      UniProtKB/Swiss-Prot
      Q3UE04, Q6ZPJ7, Q80VD3, Q8BW78, Q8K224
      Related
      ENSMUSP00000028608.7, ENSMUST00000028608.13
      Conserved Domains (6) summary
      COG1444
      Location:20901
      TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]
      pfam05127
      Location:281480
      Helicase_RecD; Helicase
      pfam08351
      Location:107201
      DUF1726; Domain of unknown function (DUF1726)
      pfam09074
      Location:8551005
      Mer2; Mer2
      pfam13718
      Location:528752
      GNAT_acetyltr_2; GNAT acetyltransferase 2
      pfam13725
      Location:775892
      tRNA_bind_2; Possible tRNA binding domain

    RNA

    1. NR_188870.1 RNA Sequence

      Status: VALIDATED

      Source sequence(s)
      BX537331
      Related
      ENSMUST00000143017.8

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      103551603..103593292 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036162741.1XP_036018634.1  RNA cytidine acetyltransferase isoform X1

    2. XM_006500455.5XP_006500518.1  RNA cytidine acetyltransferase isoform X2

      Conserved Domains (1) summary
      COG1444
      Location:20851
      TmcA; tRNA(Met) C34 N-acetyltransferase TmcA [Translation, ribosomal structure and biogenesis]