Cbx7 chromobox 7 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Cbx7provided by MGI
Official Full Name: chromobox 7provided by MGI
Primary source: MGI:MGI:1196439
See related: Ensembl:ENSMUSG00000053411 AllianceGenome:MGI:1196439
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: D15Ertd417e; 1600014J01Rik
Summary: Enables chromatin binding activity; methylated histone binding activity; and single-stranded RNA binding activity. Acts upstream of or within sebaceous gland development. Located in heterochromatin and nucleus. Part of PRC1 complex. Is expressed in brain. Human ortholog(s) of this gene implicated in breast cancer; multiple myeloma; and myeloid leukemia. Orthologous to human CBX7 (chromobox 7). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Ubiquitous expression in spleen adult (RPKM 23.7), placenta adult (RPKM 17.2) and 24 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 E1; 15 37.85 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (79800005..79855344, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (79915804..79971143, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway.
Title: CBX7 silencing promoted liver regeneration by interacting with BMI1 and activating the Nrf2/ARE signaling pathway.
Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
Title: Polycomb Group Protein CBX7 Represses Cardiomyocyte Proliferation Through Modulation of the TARDBP/RBM38 Axis.
CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.
Title: CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.
Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway.
Title: Neuroprotection of chromobox 7 knockout in the mouse after cerebral ischemia-reperfusion injury via nuclear factor E2-related factor 2/hemeoxygenase-1 signaling pathway.
A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells.
Title: A Polycomb domain found in committed cells impairs differentiation when introduced into PRC1 in pluripotent cells.
Mass spectrometry analysis revealed several non-histone protein interactions between CBX7 and the H3K9 methyltransferases SETDB1, EHMT1, and EHMT2. These CBX7-binding proteins possess a trimethylated lysine peptide motif highly similar to the canonical CBX7 target H3K27me3.
Title: CBX7 Induces Self-Renewal of Human Normal and Malignant Hematopoietic Stem and Progenitor Cells by Canonical and Non-canonical Interactions.
Knockdown of CBX7 in either embryonic cortical neurons or adult dorsal root ganglion (DRG) neurons enhances their axon growth ability. Two important transcription factors GATA4 and SOX11 are functional downstream targets of CBX7 in controlling axon regeneration.
Title: Polycomb protein family member CBX7 regulates intrinsic axon growth and regeneration.
CBX7 deficiency has a positive effect on tooth extraction socket healing.
Title: Effect of CBX7 deficiency on the socket healing after tooth extractions.
Here, by combining live-cell single-molecule tracking (SMT) and genetic engineering, the authors reveal that H3K27me3 contributes significantly to the targeting of Cbx7-PRC1 complex to chromatin.
Title: Live-cell single-molecule tracking reveals co-recognition of H3K27me3 and DNA targets polycomb Cbx7-PRC1 to chromatin.
these results of this study suggest that CBX7 deficiency plays a positive role in dentin and alveolar bone formation.
Title: CBX7 deficiency plays a positive role in dentin and alveolar bone development.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (5) 1 citation

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

AI851678 (e-PCR)
- UniSTS:164582

RH127217 (e-PCR)
- UniSTS:167158

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables chromatin binding	IDA Inferred from Direct Assay more info	PubMed
enables methylated histone binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables single-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in chromatin organization	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of transcription by RNA polymerase II	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of transcription elongation by RNA polymerase II	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within sebaceous gland development	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PRC1 complex	IDA Inferred from Direct Assay more info	PubMed
part_of PcG protein complex	ISO Inferred from Sequence Orthology more info
part_of PcG protein complex	ISS Inferred from Sequence or Structural Similarity more info
located_in chromatin	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in heterochromatin	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: chromobox protein homolog 7

Names: chromobox homolog 7

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_144811.3 → NP_659060.1 chromobox protein homolog 7

See identical proteins and their annotated locations for NP_659060.1

Status: VALIDATED

Source sequence(s)

AC113595, BC042657, BQ571764

Consensus CDS

CCDS37143.1

UniProtKB/Swiss-Prot

Q8VDS3

Related

ENSMUSP00000105245.3, ENSMUST00000109616.9

Conserved Domains (1) summary

pfam00385
Location:13 → 60

Chromo; Chromo (CHRromatin Organization MOdifier) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

79800005..79855344 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_011245690.3 → XP_011243992.1 chromobox protein homolog 7 isoform X2

UniProtKB/TrEMBL

A0A6M8AZW7

Conserved Domains (2) summary

pfam17218
Location:188 → 219

CBX7_C; CBX family C-terminal motif

cl28914
Location:15 → 41

CD_CSD; CHROMO (CHRromatin Organization Modifier) domains and chromo shadow domains
XM_011245691.3 → XP_011243993.1 chromobox protein homolog 7 isoform X3

See identical proteins and their annotated locations for XP_011243993.1

Conserved Domains (1) summary

pfam17218
Location:155 → 186

CBX7_C; CBX family C-terminal motif
XM_006521148.4 → XP_006521211.1 chromobox protein homolog 7 isoform X5

Conserved Domains (1) summary

pfam17218
Location:96 → 127

CBX7_C; CBX family C-terminal motif
XM_006521147.5 → XP_006521210.1 chromobox protein homolog 7 isoform X4

Conserved Domains (2) summary

cd18646
Location:7 → 62

CD_Cbx7; chromodomain of chromobox homolog 7

pfam17218
Location:150 → 181

CBX7_C; CBX family C-terminal motif
XM_006521144.5 → XP_006521207.1 chromobox protein homolog 7 isoform X1

UniProtKB/TrEMBL

A0A6M8AZW7, F8WHN2

Related

ENSMUSP00000086708.5, ENSMUST00000089293.11

Conserved Domains (2) summary

cd18646
Location:7 → 62

CD_Cbx7; chromodomain of chromobox homolog 7

pfam17218
Location:209 → 240

CBX7_C; CBX family C-terminal motif
XM_011245692.4 → XP_011243994.1 chromobox protein homolog 7 isoform X3

See identical proteins and their annotated locations for XP_011243994.1

Conserved Domains (1) summary

pfam17218
Location:155 → 186

CBX7_C; CBX family C-terminal motif