Erfe erythroferrone [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Erfeprovided by MGI
Official Full Name: erythroferroneprovided by MGI
Primary source: MGI:MGI:3606476
See related: Ensembl:ENSMUSG00000047443 AllianceGenome:MGI:3606476
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Fam132b; myonectin; 4832406C22
Summary: Enables hormone activity and identical protein binding activity. Involved in several processes, including negative regulation of autophagy; negative regulation of osteoblast differentiation; and positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction. Acts upstream of or within positive regulation of fatty acid transport and regulation of fatty acid metabolic process. Located in extracellular space. Orthologous to human ERFE (erythroferrone). [provided by Alliance of Genome Resources, Nov 2024]
Expression: Biased expression in large intestine adult (RPKM 5.6), colon adult (RPKM 5.2) and 14 other tissues See more
Orthologs: human all
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Genomic context

Location:: 1 D; 1 46.1 cM

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	1	NC_000067.7 (91293033..91301939)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	1	NC_000067.6 (91366305..91374217)

Chromosome 1 - NC_000067.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1alpha pathway.
Title: Myonectin protects against skeletal muscle dysfunction in male mice through activation of AMPK/PGC1α pathway.
CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1.
Title: CTRP15 promotes macrophage cholesterol efflux and attenuates atherosclerosis by increasing the expression of ABCA1.
Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice.
Title: Erythroid overproduction of erythroferrone causes iron overload and developmental abnormalities in mice.
Myonectin inhibits adipogenesis in 3T3-L1 preadipocytes by regulating p38 MAPK pathway.
Title: Myonectin inhibits adipogenesis in 3T3-L1 preadipocytes by regulating p38 MAPK pathway.
Protein Modifications Critical for Myonectin/Erythroferrone Secretion and Oligomer Assembly.
Title: Protein Modifications Critical for Myonectin/Erythroferrone Secretion and Oligomer Assembly.
ERFE bound directly to BMP2/6 heterodimers and prevented BMP2/6 binding to ALK3.
Title: Erythroferrone lowers hepcidin by sequestering BMP2/6 heterodimer from binding to the BMP type I receptor ALK3.
Female myonectin-deficient mice had larger gonadal fat pads.
Title: Myonectin deletion promotes adipose fat storage and reduces liver steatosis.
Myonectin ameliorates acute myocardial ischemic injury by suppressing apoptosis and inflammation in the heart.
Title: Myonectin Is an Exercise-Induced Myokine That Protects the Heart From Ischemia-Reperfusion Injury.
ERFE specifically abrogated the induction of hepcidin by BMP5, BMP6, and BMP7 but had little or no effect on hepcidin induction by BMP2, BMP4, BMP9, or activin B.
Title: Erythroferrone inhibits the induction of hepcidin by BMP6.
serum ERFE levels acutely increase in response to EPO in the setting of normal or impaired kidney function.
Title: Levels of the erythropoietin-responsive hormone erythroferrone in mice and humans with chronic kidney disease.

Submit: New GeneRIF Correction See all GeneRIFs (17)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (4)
Targeted (3) 1 citation

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables hormone activity	IBA Inferred from Biological aspect of Ancestor more info
enables hormone activity	IDA Inferred from Direct Assay more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of establishment of localization in cell	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in intracellular iron ion homeostasis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gluconeogenesis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of osteoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of osteoclast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of D-glucose import	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within positive regulation of fatty acid transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of insulin receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction	ISO Inferred from Sequence Orthology more info
acts_upstream_of_or_within regulation of fatty acid metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in signal transduction	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in extracellular region	IDA Inferred from Direct Assay more info	PubMed
is_active_in extracellular space	IBA Inferred from Biological aspect of Ancestor more info
located_in extracellular space	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: erythroferrone

Names: complement C1q tumor necrosis factor-related protein 15; family with sequence similarity 132, member B; protein FAM132B

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.