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    ZFP69B ZFP69 zinc finger protein B [ Homo sapiens (human) ]

    Gene ID: 65243, updated on 10-Dec-2024

    Summary

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    Official Symbol
    ZFP69Bprovided by HGNC
    Official Full Name
    ZFP69 zinc finger protein Bprovided by HGNC
    Primary source
    HGNC:HGNC:28053
    See related
    Ensembl:ENSG00000187801 AllianceGenome:HGNC:28053
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZNF643; ZSCAN54B; ZKSCAN23B
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II transcription regulatory region sequence-specific DNA binding activity. Involved in Golgi organization. Located in nucleolus. [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in brain (RPKM 1.6), appendix (RPKM 1.1) and 25 other tissues See more
    Orthologs
    all
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    Genomic context

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    See ZFP69B in Genome Data Viewer
    Location:
    1p34.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (40450064..40463715)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (40319624..40333275)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (40915736..40929387)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ribosomal protein L21 pseudogene 20 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 843 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 844 Neighboring gene small ArfGAP2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 726 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 727 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:40839657-40840156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 845 Neighboring gene Sharpr-MPRA regulatory region 11139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 728 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr1:40916242-40917441 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 729 Neighboring gene ZFP69 zinc finger protein Neighboring gene EXO5 divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 846 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 847 Neighboring gene exonuclease 5

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. ZNF643/ZFP69B Exerts Oncogenic Properties and Associates with Cell Adhesion and Immune Processes. Oleksiewicz U, et al. Int J Mol Sci, 2023 Nov 15. PMID 38003570, Free PMC Article
    2. Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response. Serebrenik YV, et al. Mol Biol Cell, 2018 Jun 1. PMID 29851555, Free PMC Article
    3. Quantitative Proteomics Reveals Dynamic Interactions of the Minichromosome Maintenance Complex (MCM) in the Cellular Response to Etoposide Induced DNA Damage. Drissi R, et al. Mol Cell Proteomics, 2015 Jul. PMID 25963833, Free PMC Article
    4. Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. Brandenberger R, et al. Nat Biotechnol, 2004 Jun. PMID 15146197
    5. Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei. Fasci D, et al. Mol Cell Proteomics, 2018 Oct. PMID 30021884, Free PMC Article

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ZNF643/ZFP69B Exerts Oncogenic Properties and Associates with Cell Adhesion and Immune Processes.
      Title: ZNF643/ZFP69B Exerts Oncogenic Properties and Associates with Cell Adhesion and Immune Processes.
    Submit: New GeneRIF Correction

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Clone Names

    • FLJ34293

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in Golgi organization IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    zinc finger protein 69 homolog B
    Names
    novel zinc finger protein
    zinc finger protein 643
    zinc finger protein ZFP69B

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001369565.1 → NP_001356494.1  zinc finger protein 69 homolog B

      Status: VALIDATED

      Source sequence(s)
      AL031985
      Consensus CDS
      CCDS452.2
      UniProtKB/Swiss-Prot
      Q5QPL4, Q9UJL9
      Related
      ENSP00000399664.2, ENST00000411995.6
      Conserved Domains (5) summary
      smart00349
      Location:74 → 133
      KRAB; krueppel associated box
      COG5048
      Location:221 → 429
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:433 → 458
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:2 → 40
      SCAN; SCAN oligomerization domain

    2. NM_023070.3 → NP_075558.2  zinc finger protein 69 homolog B

      See identical proteins and their annotated locations for NP_075558.2

      Status: VALIDATED

      Source sequence(s)
      AL031985, BC017498, CN256362
      Consensus CDS
      CCDS452.2
      UniProtKB/Swiss-Prot
      Q5QPL4, Q9UJL9
      Related
      ENSP00000354547.4, ENST00000361584.5
      Conserved Domains (5) summary
      smart00349
      Location:74 → 133
      KRAB; krueppel associated box
      COG5048
      Location:221 → 429
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:309 → 329
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:433 → 458
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:2 → 40
      SCAN; SCAN oligomerization domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      40450064..40463715
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005271136.2 → XP_005271193.1  zinc finger protein 69 homolog B isoform X1

      Related
      ENST00000469416.1
      Conserved Domains (5) summary
      smart00349
      Location:74 → 134
      KRAB; krueppel associated box
      COG5048
      Location:194 → 430
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:434 → 459
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:2 → 40
      SCAN; SCAN oligomerization domain

    2. XM_017002147.2 → XP_016857636.1  zinc finger protein 69 homolog B isoform X1

      Conserved Domains (5) summary
      smart00349
      Location:74 → 134
      KRAB; krueppel associated box
      COG5048
      Location:194 → 430
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:310 → 330
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam13465
      Location:434 → 459
      zf-H2C2_2; Zinc-finger double domain
      cl02605
      Location:2 → 40
      SCAN; SCAN oligomerization domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      40319624..40333275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338413.1 → XP_054194388.1  zinc finger protein 69 homolog B isoform X1

    2. XM_054338414.1 → XP_054194389.1  zinc finger protein 69 homolog B isoform X1

    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9UJL9.2 GenPept UniProtKB/Swiss-Prot:Q9UJL9

    Gene LinkOut

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