MT1F metallothionein 1F [Homo sapiens (human)] - Gene

Summary

Official Symbol: MT1Fprovided by HGNC
Official Full Name: metallothionein 1Fprovided by HGNC
Primary source: HGNC:HGNC:7398
See related: Ensembl:ENSG00000198417 MIM:156352; AllianceGenome:HGNC:7398
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: MT1
Summary: Predicted to enable zinc ion binding activity. Involved in cellular response to cadmium ion and cellular response to zinc ion. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in thyroid (RPKM 263.0), kidney (RPKM 198.1) and 9 other tissues See more
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Genomic context

Location:: 16q13

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2024_08	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (56657959..56659303)
RS_2024_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (62452925..62454269)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (56691871..56693215)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

we found that metallothionein expression induced by Cd occurred much later, with the expression seen at least 12h or more after the Nrf2-dependent immediate responses were almost completed.
Title: Significance of the rapid increase in GSH levels in the protective response to cadmium exposure through phosphorylated Nrf2 signaling in Jurkat T-cells.
Metallothionein may have a role in the control of apoptosis in pleomorphic adenoma.
Title: Immunohistochemical expression of metallothionein in pleomorphic adenoma of minor salivary glands: a role in the control of apoptosis?
Aortic protection in diabetes by zinc supplementation is associated with upregulation of both metallothionein and Nrf2 expression.
Title: Zinc protects against diabetes-induced pathogenic changes in the aorta: roles of metallothionein and nuclear factor (erythroid-derived 2)-like 2.
findings show 5 MT isoforms were overexpressed in non-small cell lung cancer and overexpression of MT-1F and MT-2A predicted poor outcome; both isoforms may be involved in progression of this cancer type; upregulated MT-1F expression associated with larger primary tumor size and higher grade of malignanacy
Title: Metallothionein 1F and 2A overexpression predicts poor outcome of non-small cell lung cancer patients.
MT1F is a putative tumor suppressor gene in colon carcinogenesis that is downregulated mainly by loss of heterozygosity in colon cancer tissue
Title: Downregulation of metallothionein 1F, a putative oncosuppressor, by loss of heterozygosity in colon cancer tissue.
This study identifies for the first time the relevant metallothionein isoforms for colorectal cancer progression.
Title: Metallothionein expression in colorectal cancer: relevance of different isoforms for tumor progression and patient survival.
Studies provide the mechanistic properties of metal binding for metallothionein metallation.
Title: The "magic numbers" of metallothionein.
MT-1 rs8052394 A allele is associated with oral squamous cell carcinoma.
Title: Metallothionein-1 genotypes in the risk of oral squamous cell carcinoma.
MT-1A, -1F, -1G, -1X and -2A isoforms are significantly down-regulated in proliferating keloid fibroblasts.
Title: Modulation of metallothionein isoforms is associated with collagen deposition in proliferating keloid fibroblasts in vitro.
Knockdown of MT1F gene increased particular matter(2.5)-induced H2O2 release in alveolar macrophages.
Title: Fine ambient particles induce oxidative stress and metal binding genes in human alveolar macrophages.

Submit: New GeneRIF Correction See all GeneRIFs (11)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study of a quantitative disordered gambling trait. EBI GWAS Catalog EBI GWAS CatalogPubMed
Many sequence variants affecting diversity of adult human height. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	Microarray analysis indicates HIV-1 Tat upregulates the interferon-responsive gene expression of many proteins, including Metallothionein, in immature dendritic cells, an effect that likely facilitates the expansion of HIV-1 infection	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH78925 (e-PCR)
- UniSTS:31007

D16S3240 (e-PCR)
- UniSTS:2114

PMC164851P1 (e-PCR)
- UniSTS:271521

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables metal ion binding	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in cellular response to cadmium ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to cadmium ion	IEP Inferred from Expression Pattern more info	PubMed
involved_in cellular response to copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to zinc ion	ISS Inferred from Sequence or Structural Similarity more info
involved_in detoxification of copper ion	IBA Inferred from Biological aspect of Ancestor more info
involved_in intracellular zinc ion homeostasis	IBA Inferred from Biological aspect of Ancestor more info
involved_in negative regulation of growth	ISS Inferred from Sequence or Structural Similarity more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: metallothionein-1F

Names: MT-1F; MT-IF; metallothionein 1F (functional); metallothionein-IF

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301272.2 → NP_001288201.1 metallothionein-1F isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region, compared to variant 1, which results in a shorter isoform (2) with a novel C-terminus, compared to isoform 1.

Source sequence(s)

BC029453, BM919862, W78077

Consensus CDS

CCDS76872.1

UniProtKB/TrEMBL

H3BRY8

Related

ENSP00000456462.1, ENST00000568475.1

Conserved Domains (1) summary

pfam00131
Location:5 → 34

Metallothio; Metallothionein
NM_005949.4 → NP_005940.1 metallothionein-1F isoform 1

See identical proteins and their annotated locations for NP_005940.1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the shorter transcript but encodes the longer isoform (1).

Source sequence(s)

BC029453, BQ939879

Consensus CDS

CCDS32456.1

UniProtKB/Swiss-Prot

P04733, Q93083, Q9UI97

UniProtKB/TrEMBL

Q8TE66

Related

ENSP00000334872.6, ENST00000334350.7

Conserved Domains (1) summary

pfam00131
Location:1 → 60

Metallothio; Metallothionein