Oaz1 ornithine decarboxylase antizyme 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Oaz1provided by MGI
Official Full Name: ornithine decarboxylase antizyme 1provided by MGI
Primary source: MGI:MGI:109433
See related: Ensembl:ENSMUSG00000035242 AllianceGenome:MGI:109433
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: AZ1; Oaz; AZ-1; ODC-Az; Antizyme
Summary: The protein encoded by this gene belongs to the ornithine decarboxylase antizyme family, which plays a role in cell growth and proliferation by regulating intracellular polyamine levels. Expression of antizymes requires +1 ribosomal frameshifting, which is enhanced by high levels of polyamines. Antizymes in turn bind to and inhibit ornithine decarboxylase (ODC), the key enzyme in polyamine biosynthesis; thus, completing the auto-regulatory circuit. This gene encodes antizyme 1, the first member of the antizyme family, that has broad tissue distribution, and negatively regulates intracellular polyamine levels by binding to and targeting ODC for degradation, as well as inhibiting polyamine uptake. Antizyme 1 mRNA contains two potential in-frame AUGs; and studies in rat suggest that alternative use of the two translation initiation sites results in N-terminally distinct protein isoforms with different subcellular localization. Alternatively spliced transcript variants have also been noted for this gene. [provided by RefSeq, Dec 2014]
Expression: Ubiquitous expression in adrenal adult (RPKM 386.0), thymus adult (RPKM 368.7) and 28 other tissues See more
Orthologs: human all
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Genomic context

Location:: 10 C1; 10 39.72 cM

Exon count:: 5

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	10	NC_000076.7 (80662490..80665124)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	10	NC_000076.6 (80826656..80829290)

Chromosome 10 - NC_000076.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Amyloid beta may contribute to M1-like activation by disrupting the balance between ODC and AZ in microglia.
Title: Aβ stimulates microglial activation through antizyme-dependent downregulation of ornithine decarboxylase.
Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).
Title: Interaction of polyamines and mTOR signaling in the synthesis of antizyme (AZ).
we have generated transgenic mice overexpressing mouse antizyme 1 gene under its own regulatory sequences
Title: Systemic overexpression of antizyme 1 in mouse reduces ornithine decarboxylase activity without major changes in tissue polyamine homeostasis.
Ornithine decarboxylase antizyme expression reduces tumor incidence, multiplicity and size even in the absence of p53.
Title: Targeted expression of ornithine decarboxylase antizyme prevents upper aerodigestive tract carcinogenesis in p53-deficient mice.
The activity of AZ1 was low in the virgin and involuting stages, but increased markedly during late pregnancy and early lactation.
Title: Developmental alterations in expression and subcellular localization of antizyme and antizyme inhibitor and their functional importance in the murine mammary gland.
These data together demonstrate the existence of a c-Jun-dependent mechanism regulating the abundance of the antiapoptotic DNp73 in response to genotoxic stress.
Title: The antiapoptotic DeltaNp73 is degraded in a c-Jun-dependent manner upon genotoxic stress through the antizyme-mediated pathway.
The data-driven docking results suggest that both proteins occupy the same binding site on Az1, with Az1 binding within a large groove in antizyme inhibitor (AzI) and Ornithine Decarboxylase (ODC).
Title: Docking of antizyme to ornithine decarboxylase and antizyme inhibitor using experimental mutant and double-mutant cycle data.
required for the proper formation of forebrain and hindbrain midline structures
Title: The transcription factor Zfp423/OAZ is required for cerebellar development and CNS midline patterning.
OAZ can alter the intensity and duration of the BMP4 stimulus through Smad6
Title: OAZ regulates bone morphogenetic protein signaling through Smad6 activation.
Az-1 has a central and meaningful role in modulation of polyamine homeostasis, and in regulating cellular proliferation and transformation properties.
Title: Overexpression of antizyme-inhibitor in NIH3T3 fibroblasts provides growth advantage through neutralization of antizyme functions.

Submit: New GeneRIF Correction See all GeneRIFs (13)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Targeted (2)

General gene information

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Markers

Oaz1 (e-PCR), detects polymorphism
- UniSTS:531478

RH127959 (e-PCR)
- UniSTS:211269

Oaz1 (e-PCR), detects polymorphism
- UniSTS:144075

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables enzyme binding	ISO Inferred from Sequence Orthology more info
enables ornithine decarboxylase inhibitor activity	IBA Inferred from Biological aspect of Ancestor more info
enables ornithine decarboxylase inhibitor activity	IDA Inferred from Direct Assay more info	PubMed
enables ornithine decarboxylase inhibitor activity	IGI Inferred from Genetic Interaction more info
enables ornithine decarboxylase inhibitor activity	ISO Inferred from Sequence Orthology more info
enables ornithine decarboxylase inhibitor activity	TAS Traceable Author Statement more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein-containing complex binding	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in cellular response to leptomycin B	ISO Inferred from Sequence Orthology more info
involved_in cellular response to polyamine macromolecule	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of ornithine catabolic process	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of polyamine transmembrane transport	IDA Inferred from Direct Assay more info
involved_in negative regulation of polyamine transmembrane transport	ISO Inferred from Sequence Orthology more info
involved_in polyamine biosynthetic process	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within polyamine metabolic process	TAS Traceable Author Statement more info	PubMed
involved_in positive regulation of intracellular protein transport	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of proteasomal protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of protein catabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of protein catabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in positive regulation of protein catabolic process	ISO Inferred from Sequence Orthology more info
involved_in viral translational frameshifting	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	ISO Inferred from Sequence Orthology more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: ornithine decarboxylase antizyme 1

Names: antizyme 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001301034.1 → NP_001287963.1 ornithine decarboxylase antizyme 1 isoform 2

Status: REVIEWED

Description

Transcript Variant: This variant (2) uses an alternate, in-frame acceptor splice site at the second exon compared to variant 1. The resulting isoform (2) lacks 2 internal amino acids compared to isoform 1.

Source sequence(s)

AA270439, AI838943, AK146571, BY112600

UniProtKB/TrEMBL

J3QMV2

Related

ENSMUSP00000136469.2, ENSMUST00000177850.8

Conserved Domains (1) summary

pfam02100
Location:128 → 216

ODC_AZ; Ornithine decarboxylase antizyme
NM_008753.4 → NP_032779.2 ornithine decarboxylase antizyme 1 isoform 1

See identical proteins and their annotated locations for NP_032779.2

Status: REVIEWED

Description

Transcript Variant: This variant (1) encodes the longer isoform (1).

Source sequence(s)

AI838943, AK146571, BY112600

Consensus CDS

CCDS56736.1

UniProtKB/Swiss-Prot

O08610, P54369

UniProtKB/TrEMBL

J3QMV2

Related

ENSMUSP00000137400.2, ENSMUST00000180036.8

Conserved Domains (1) summary

pfam02100
Location:128 → 218

ODC_AZ; Ornithine decarboxylase antizyme