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    THRB thyroid hormone receptor beta [ Homo sapiens (human) ]

    Gene ID: 7068, updated on 10-Dec-2024

    Summary

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    Official Symbol
    THRBprovided by HGNC
    Official Full Name
    thyroid hormone receptor betaprovided by HGNC
    Primary source
    HGNC:HGNC:11799
    See related
    Ensembl:ENSG00000151090 MIM:190160; AllianceGenome:HGNC:11799
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TRb; GRTH; PRTH; THR1; ERBA2; NR1A2; THRB1; THRB2; TRbeta; THRbeta; TRbeta1; C-ERBA-2; THRbeta1; Thrbeta2; C-ERBA-BETA
    Summary
    The protein encoded by this gene is a nuclear hormone receptor for triiodothyronine. It is one of the several receptors for thyroid hormone, and has been shown to mediate the biological activities of thyroid hormone. Knockout studies in mice suggest that the different receptors, while having certain extent of redundancy, may mediate different functions of thyroid hormone. Mutations in this gene are known to be a cause of generalized thyroid hormone resistance (GTHR), a syndrome characterized by goiter and high levels of circulating thyroid hormone (T3-T4), with normal or slightly elevated thyroid stimulating hormone (TSH). Several alternatively spliced transcript variants encoding the same protein have been observed for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in brain (RPKM 8.1), fat (RPKM 4.3) and 22 other tissues See more
    Orthologs
    mouse all
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    Genomic context

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    See THRB in Genome Data Viewer
    Location:
    3p24.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (24117153..24495708, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (24121636..24500130, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (24158644..24537199, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 691 Neighboring gene nucleophosmin 1 pseudogene 23 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr3:24184437-24185636 Neighboring gene MPRA-validated peak4578 silencer Neighboring gene THRB antisense RNA 2 Neighboring gene GATA motif-containing MPRA enhancer 252 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:24401392-24402024 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:24437700-24438265 Neighboring gene Sharpr-MPRA regulatory region 12793 Neighboring gene HNF4 motif-containing MPRA enhancer 120 Neighboring gene ribosomal protein L31 pseudogene 20 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:24538119-24538324 Neighboring gene uncharacterized LOC107986011 Neighboring gene THRB antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:24560666-24561278 Neighboring gene eukaryotic translation initiation factor 3 subunit K pseudogene 2

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Untranslated regions of thyroid hormone receptor beta 1 mRNA are impaired in human clear cell renal cell carcinoma. Master A, et al. Biochim Biophys Acta, 2010 Nov. PMID 20691260
    2. Pathogenic mechanism of mutations in the thyroid hormone receptor β gene. Pongjantarasatian S, et al. J Endocrinol Invest, 2012 Jun. PMID 21795843
    3. A new mutation in the thyroid hormone receptor gene of a Chinese family with resistance to thyroid hormone. Dong Q, et al. Chin Med J (Engl), 2011 Jun. PMID 21740842
    4. [Clinical and molecular study of five families with resistance to thyroid hormones]. Lado Abeal J, et al. Med Clin (Barc), 2011 Nov 12. PMID 21703645
    5. A mechanism for pituitary-resistance to thyroid hormone (PRTH) syndrome: a loss in cooperative coactivator contacts by thyroid hormone receptor (TR)beta2. Lee S, et al. Mol Endocrinol, 2011 Jul. PMID 21622532, Free PMC Article

    See all (297) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Thyroid hormone Beta receptor agonists for treatment of kidney disease: A promising agent?
      Title: Thyroid hormone Beta receptor agonists for treatment of kidney disease: A promising agent?
    2. Effect of the Fetal THRB Genotype on the Placenta.
      Title: Effect of the Fetal THRB Genotype on the Placenta.
    3. Atrial Fibrillation with Heart Failure in a Case with Resistance to Thyroid Hormone Due to a Rare Thyroid Hormone Receptor beta Gene Mutation.
      Title: Atrial Fibrillation with Heart Failure in a Case with Resistance to Thyroid Hormone Due to a Rare Thyroid Hormone Receptor β Gene Mutation.
    4. Low THRB (thyroid hormone receptor beta) Promoter Methylation Levels in Peripheral Blood Leukocytes Induced By Systematic Inflammation Are Involved in Low Thyroid Hormone Function in Metabolic Syndrome.
      Title: Low THRB (thyroid hormone receptor beta) Promoter Methylation Levels in Peripheral Blood Leukocytes Induced By Systematic Inflammation Are Involved in Low Thyroid Hormone Function in Metabolic Syndrome.
    5. Life Without Thyroid Hormone Receptor.
      Title: Life Without Thyroid Hormone Receptor.
    6. Structural insights revealed by two novel THRB mutations.
      Title: Structural insights revealed by two novel THRB mutations.
    7. Hypercholesterolemia in Two Siblings with Resistance to Thyroid Hormones Due to Disease-Causing Variant in Thyroid Hormone Receptor (THRB) Gene.
      Title: Hypercholesterolemia in Two Siblings with Resistance to Thyroid Hormones Due to Disease-Causing Variant in Thyroid Hormone Receptor (THRB) Gene.
    8. Identification of a novel subgroup of endometrial cancer patients with loss of thyroid hormone receptor beta expression and improved survival.
      Title: Identification of a novel subgroup of endometrial cancer patients with loss of thyroid hormone receptor beta expression and improved survival.
    9. Patients with mutations of the Thyroid hormone beta-receptor show an ADHD-like phenotype for performance monitoring: an electrophysiological study.
      Title: Patients with mutations of the Thyroid hormone beta-receptor show an ADHD-like phenotype for performance monitoring: an electrophysiological study.
    10. Characterization of adipogenic, PPARgamma, and TRbeta activities in house dust extracts and their associations with organic contaminants.
      Title: Characterization of adipogenic, PPARγ, and TRβ activities in house dust extracts and their associations with organic contaminants.
    Submit: New GeneRIF Correction See all GeneRIFs (164)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Selective pituitary resistance to thyroid hormone
    MedGen: C1840364 OMIM: 145650 GeneReviews: Not available
    		Compare labs
    Thyroid hormone resistance, generalized, autosomal dominant
    MedGen: C2937288 OMIM: 188570 GeneReviews: Not available
    		Compare labs
    Thyroid hormone resistance, generalized, autosomal recessive
    MedGen: C3489796 OMIM: 274300 GeneReviews: Not available
    		Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association study identifies three novel susceptibility loci for severe Acne vulgaris.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog
    Genome-wide meta-analysis of systolic blood pressure in children with sickle cell disease.
    EBI GWAS Catalog
    Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche.
    EBI GWAS Catalog
    Seventy-five genetic loci influencing the human red blood cell.
    EBI GWAS Catalog

    Variation

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    See Variation Viewer (GRCh37.p13)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC126109, MGC126110

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables chromatin DNA binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nuclear receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nuclear receptor activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables sequence-specific double-stranded DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables thyroid hormone binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription coactivator binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables zinc ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in DNA-templated transcription TAS
    Traceable Author Statement
    more info
    		 PubMed 
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to thyroid hormone stimulus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in female courtship behavior IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in mRNA transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in negative regulation of female receptivity IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of thyroid hormone receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in regulation of heart contraction IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinal cone cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinal cone cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in retinoic acid receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in sensory perception of sound IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in thyroid hormone receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in type I pneumocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of RNA polymerase II transcription regulator complex IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chromatin ISA
    Inferred from Sequence Alignment
    more info
    		  
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
    		  
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    thyroid hormone receptor beta
    Names
    nuclear receptor subfamily 1 group A member 2
    oncogene ERBA2
    thyroid hormone receptor, beta (erythroblastic leukemia viral (v-erb-a) oncogene homolog 2, avian)

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009159.1 RefSeqGene

      Range
      4973..382670
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000461.5 → NP_000452.2  thyroid hormone receptor beta isoform a

      See identical proteins and their annotated locations for NP_000452.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes the longer isoform (a). Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AC012087, AC098971, AK095776, AW449568, BC028910, BC106929, BP313943, M26747
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Related
      ENSP00000379904.2, ENST00000396671.7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    2. NM_001128176.3 → NP_001121648.1  thyroid hormone receptor beta isoform a

      See identical proteins and their annotated locations for NP_001121648.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AC012087, AC098971, AW449568, AY286468, BC106930, GQ869477
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Related
      ENSP00000348827.4, ENST00000356447.9
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    3. NM_001128177.2 → NP_001121649.1  thyroid hormone receptor beta isoform a

      See identical proteins and their annotated locations for NP_001121649.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AC012087, AC098971, AK095776, AK096628, AW449568, BC028910, M26747
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    4. NM_001252634.2 → NP_001239563.1  thyroid hormone receptor beta isoform a

      See identical proteins and their annotated locations for NP_001239563.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AC012087, AC098971, AK096628, AW449568, GQ869477
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Related
      ENSP00000414444.1, ENST00000416420.5
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    5. NM_001354708.2 → NP_001341637.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    6. NM_001354709.2 → NP_001341638.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    7. NM_001354710.2 → NP_001341639.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    8. NM_001354711.2 → NP_001341640.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    9. NM_001354712.2 → NP_001341641.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Related
      ENSP00000496686.2, ENST00000646209.2
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    10. NM_001354713.2 → NP_001341642.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 1. Variants 1-10 all encode the same isoform (a).
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    11. NM_001354714.2 → NP_001341643.1  thyroid hormone receptor beta isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Conserved Domains (2) summary
      cd06935
      Location:185 → 427
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:75 → 161
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    12. NM_001354715.2 → NP_001341644.1  thyroid hormone receptor beta isoform b

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Conserved Domains (2) summary
      cd06935
      Location:185 → 427
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:75 → 161
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    13. NM_001374822.1 → NP_001361751.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 1-10 and 14-17, encodes isoform a.
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Related
      ENSP00000493709.1, ENST00000645139.1
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    14. NM_001374823.1 → NP_001361752.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 1-10, 13, and 15-17, encodes isoform a.
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Related
      ENSP00000494618.1, ENST00000642307.1
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    15. NM_001374824.1 → NP_001361753.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variants 1-10, 13, 14, 16, and 17, encodes isoform a.
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Related
      ENSP00000496029.1, ENST00000643772.1
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    16. NM_001374825.1 → NP_001361754.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variants 1-10, 13-15, and 17, encodes isoform a.
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Related
      ENSP00000496616.1, ENST00000644321.1
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    17. NM_001374826.1 → NP_001361755.1  thyroid hormone receptor beta isoform a

      Status: REVIEWED

      Description
      Transcript Variant: This variant (17), as well as variants 1-10 and 13-16, encodes isoform a.
      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Consensus CDS
      CCDS2641.1
      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    18. NM_001374827.1 → NP_001361756.1  thyroid hormone receptor beta isoform c

      Status: REVIEWED

      Source sequence(s)
      AC012087, AC093927, AC098971, AC099054
      Conserved Domains (2) summary
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers
      cl11397
      Location:216 → 401
      NR_LBD; The ligand binding domain of nuclear receptors, a family of ligand-activated transcription regulators

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      24117153..24495708 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448794.1 → XP_047304750.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    2. XM_047448810.1 → XP_047304766.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    3. XM_047448801.1 → XP_047304757.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    4. XM_047448799.1 → XP_047304755.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    5. XM_047448803.1 → XP_047304759.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    6. XM_047448796.1 → XP_047304752.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    7. XM_024453734.2 → XP_024309502.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    8. XM_047448811.1 → XP_047304767.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    9. XM_047448791.1 → XP_047304747.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    10. XM_047448813.1 → XP_047304769.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    11. XM_047448802.1 → XP_047304758.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    12. XM_047448807.1 → XP_047304763.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    13. XM_047448798.1 → XP_047304754.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    14. XM_047448789.1 → XP_047304745.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    15. XM_047448805.1 → XP_047304761.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    16. XM_047448817.1 → XP_047304773.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    17. XM_047448812.1 → XP_047304768.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    18. XM_047448793.1 → XP_047304749.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    19. XM_047448806.1 → XP_047304762.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    20. XM_047448792.1 → XP_047304748.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    21. XM_047448809.1 → XP_047304765.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    22. XM_047448808.1 → XP_047304764.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    23. XM_017007113.2 → XP_016862602.1  thyroid hormone receptor beta isoform X2

      Conserved Domains (2) summary
      cd06935
      Location:185 → 427
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:75 → 161
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    24. XM_011534050.3 → XP_011532352.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_011532352.1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    25. XM_047448800.1 → XP_047304756.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    26. XM_047448818.1 → XP_047304774.1  thyroid hormone receptor beta isoform X2

    27. XM_011534047.4 → XP_011532349.1  thyroid hormone receptor beta isoform X1

      See identical proteins and their annotated locations for XP_011532349.1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    28. XM_047448814.1 → XP_047304770.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    29. XM_047448815.1 → XP_047304771.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    30. XM_047448804.1 → XP_047304760.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    31. XM_047448795.1 → XP_047304751.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    32. XM_047448790.1 → XP_047304746.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    33. XM_047448797.1 → XP_047304753.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Related
      ENSP00000496509.1, ENST00000646432.1

    34. XM_047448816.1 → XP_047304772.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    35. XM_024453737.2 → XP_024309505.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
      Conserved Domains (2) summary
      cd06935
      Location:216 → 458
      NR_LBD_TR; The ligand binding domain of thyroid hormone receptor, a members of a superfamily of nuclear receptors
      cd06961
      Location:106 → 192
      NR_DBD_TR; DNA-binding domain of thyroid hormone receptors (TRs) is composed of two C4-type zinc fingers

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      24121636..24500130 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347675.1 → XP_054203650.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    2. XM_054347692.1 → XP_054203667.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    3. XM_054347682.1 → XP_054203657.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    4. XM_054347680.1 → XP_054203655.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    5. XM_054347684.1 → XP_054203659.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    6. XM_054347677.1 → XP_054203652.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    7. XM_054347670.1 → XP_054203645.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    8. XM_054347693.1 → XP_054203668.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    9. XM_054347672.1 → XP_054203647.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    10. XM_054347695.1 → XP_054203670.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    11. XM_054347683.1 → XP_054203658.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    12. XM_054347687.1 → XP_054203662.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    13. XM_054347679.1 → XP_054203654.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    14. XM_054347669.1 → XP_054203644.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    15. XM_054347686.1 → XP_054203661.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    16. XM_054347701.1 → XP_054203676.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    17. XM_054347694.1 → XP_054203669.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    18. XM_054347674.1 → XP_054203649.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    19. XM_054347688.1 → XP_054203663.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    20. XM_054347673.1 → XP_054203648.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    21. XM_054347690.1 → XP_054203665.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    22. XM_054347689.1 → XP_054203664.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    23. XM_054347703.1 → XP_054203678.1  thyroid hormone receptor beta isoform X2

    24. XM_054347691.1 → XP_054203666.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    25. XM_054347681.1 → XP_054203656.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    26. XM_054347702.1 → XP_054203677.1  thyroid hormone receptor beta isoform X2

    27. XM_054347668.1 → XP_054203643.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    28. XM_054347699.1 → XP_054203674.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    29. XM_054347696.1 → XP_054203671.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    30. XM_054347698.1 → XP_054203673.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    31. XM_054347685.1 → XP_054203660.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    32. XM_054347676.1 → XP_054203651.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    33. XM_054347671.1 → XP_054203646.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    34. XM_054347678.1 → XP_054203653.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    35. XM_054347700.1 → XP_054203675.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7

    36. XM_054347697.1 → XP_054203672.1  thyroid hormone receptor beta isoform X1

      UniProtKB/Swiss-Prot
      B3KU79, P10828, P37243, Q13986, Q3KP35, Q6WGL2, Q9UD41
      UniProtKB/TrEMBL
      A0A024R2I8, F1D8N7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P10828.2 GenPept UniProtKB/Swiss-Prot:P10828

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